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• W2910840103 abstract "Significance The involvement of nonhistone protein methylation in cellular essential pathways is a rising field. Here we show evidence for the involvement of direct lysine methylation of the mitosis regulator PLK1 by SETD6 methyltransferase in cell cycle promotion. Our results reveal that this methylation occurs on two lysine residues and that lack of methylation leads to enhanced PLK1 catalytic activity, causing accelerated mitosis pace and thus faster proliferation rates. These findings suggest that PLK1 methylation by SETD6 controls the pace of mitotic progression, greatly enhancing our understanding of cell cycle complexity. The role of methylation in mitotic progression raises the possibility of its involvement in tumorigenic pathways by orchestrating cell division rates and might have insightful implications for the development of cancer-specific markers." @default.
• W2910840103 created "2019-01-25" @default.
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• W2910840103 date "2019-01-08" @default.
• W2910840103 modified "2023-10-02" @default.
• W2910840103 title "The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation" @default.
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• W2910840103 doi "https://doi.org/10.1073/pnas.1804407116" @default.
• W2910840103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347700" @default.
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