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- W2910851937 endingPage "379" @default.
- W2910851937 startingPage "367" @default.
- W2910851937 abstract "Site-specific colon drug delivery is a practical approach for the treatment of local diseases of the colon with several advantages such as rapid onset of action and reduction of the dosage of the drug as well as minimization of harmful side effects. 5-aminosalicylic acid (5-ASA) is a drug of choice in the treatment of inflammatory bowel disease and colitis. For the efficient delivery of this drug, it is vital to prevent 5-ASA release in the upper part of the gastrointestinal tract and to promote its release in the proximal colon. Different approaches including chemical manipulation of drug molecule for production of prodrugs or modification of drug delivery systems using pH-dependent, time-dependent and/or bacterially biodegradable materials have been tried to optimize 5-ASA delivery to the colon. In the current review, the different strategies utilized in the design and development of an oral colonic delivery dosage form of 5-ASA are presented and discussed." @default.
- W2910851937 created "2019-01-25" @default.
- W2910851937 creator A5006644861 @default.
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- W2910851937 creator A5038390046 @default.
- W2910851937 creator A5056685607 @default.
- W2910851937 creator A5066599203 @default.
- W2910851937 date "2019-03-01" @default.
- W2910851937 modified "2023-10-12" @default.
- W2910851937 title "A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems" @default.
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