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- W2910859466 abstract "In this study, it was aimed to investigate the effects of oleuropein on hyperglycemia and oxidant-antioxidant levels in metformin-insulin treated streptozotocin-diabetic rats. For this purpose, 40 Sprague-Dawley rats were used. Animals were divided into 5 groups as 4 experimental and 1 Control each containing 8 rats. 1 ml isotonic NaCl solution was injected intraperitoneally (ip) to the Control group while 50 mg/kg STZ ip was given to the G1, 50 mg/kg STZ + 100 mg/kg Metformin + 4 IU/kg insulin ip was given to the G2, 50 mg/kg STZ + 100 mg/kg Metformin + 4 IU/kg insulin ip and 30 mg/kg orally oleuropein was given to the G3 and 50 mg/kg STZ ip and 30 mg/kg oleuropein orally was given to the G4. Blood glucose values were statistically higher in the experimental groups than the control after streptozotocin administration (P<0.001, P<0.01, P<0.01 respectively). Plasma Total Antioxidant Capacity (TAC) of G2 and G3 were statistically higher than G1 (P<0.001). It was found that plasma TAC levels of G3 were statistically higher than the control (P<0.05). It was determined that the G1 (P<0.001), G2 (P<0.01) and G3 (P<0.05) group had significantly higher plasma Total Oxidant Capacity (TOC) than the control group. TAC levels in the liver of the experimental groups were determined to be statistically insignificant according to the control group. The liver TOC levels of the G2 and G4 group were significantly higher than the control group (P<0.01, P<0.001 respectively). In conclusion, the use of oleuropein alone did not affect the blood glucose level, the live weight, the plasma and the liver TAC and TOC levels, but the use of metformin and insulin with oleuropein as an antioxidant and free radical scavenger following to the rising oxidation in diabetes were supported and strengthen the system." @default.
- W2910859466 created "2019-01-25" @default.
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- W2910859466 date "2018-12-27" @default.
- W2910859466 modified "2023-09-27" @default.
- W2910859466 title "Effects of Oleuropein on Hyperglycemia, Total Oxidant and Antioxidant Capacity in Streptozotosin-Diabetic Rats Treated with Metformin and Insulin" @default.
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- W2910859466 doi "https://doi.org/10.31196/huvfd.508862" @default.
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