FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910865326> ?p ?o ?g. }

• W2910865326 endingPage "e12556" @default.
• W2910865326 startingPage "e12556" @default.
• W2910865326 abstract "Glioblastoma (GBM) is the most aggressive malignant glioma and most lethal form of human brain cancer (Clin J Oncol Nurs. 2016;20:S2). GBM is also one of the most expensive and difficult cancers to treat by the surgical resection, local radiotherapy, and temozolomide (TMZ) and still remains an incurable disease. Oncomine platform analysis and Gene Expression Profiling Interactive Analysis (GEPIA) show that the expression of transcription factor EB (TFEB) was significantly increased in GBMs and in GBM patients above stage IV. TFEB requires the oligomerization and localization to regulate transcription in the nucleus. Also, the expression and oligomerization of TFEB proteins contribute to the resistance of GBM cells to conventional chemotherapeutic agents such as TMZ. Thus, we investigated whether the combination of vorinostat and melatonin could overcome the effects of TFEB and induce apoptosis in GBM cells and glioma cancer stem cells (GSCs). The downregulation of TFEB and oligomerization by vorinostat and melatonin increased the expression of apoptosis-related genes and activated the apoptotic cell death process. Significantly, the inhibition of TFEB expression dramatically decreased GSC tumor-sphere formation and size. The inhibitory effect of co-treatment resulted in decreased proliferation of GSCs and induced the expression of cleaved PARP and p-γH2AX. Taken together, our results definitely demonstrate that TFEB expression contributes to enhanced resistance of GBMs to chemotherapy and that vorinostat- and melatonin-activated apoptosis signaling in GBM cells by inhibiting TFEB expression and oligomerization, suggesting that co-treatment of vorinostat and melatonin may be an effective therapeutic strategy for human brain cancers." @default.
• W2910865326 created "2019-01-25" @default.
• W2910865326 creator A5016029445 @default.
• W2910865326 creator A5028959139 @default.
• W2910865326 creator A5051356020 @default.
• W2910865326 creator A5054288237 @default.
• W2910865326 creator A5059663288 @default.
• W2910865326 creator A5074994491 @default.
• W2910865326 creator A5078229246 @default.
• W2910865326 creator A5086752664 @default.
• W2910865326 date "2019-02-14" @default.
• W2910865326 modified "2023-09-27" @default.
• W2910865326 title "Inhibition of TFEB oligomerization by co-treatment of melatonin with vorinostat promotes the therapeutic sensitivity in glioblastoma and glioma stem cells" @default.
• W2910865326 cites W1754595315 @default.
• W2910865326 cites W1827324319 @default.
• W2910865326 cites W1861134585 @default.
• W2910865326 cites W1918114876 @default.
• W2910865326 cites W1954903755 @default.
• W2910865326 cites W1966292905 @default.
• W2910865326 cites W1967058999 @default.
• W2910865326 cites W1972500796 @default.
• W2910865326 cites W1987752089 @default.
• W2910865326 cites W1994901446 @default.
• W2910865326 cites W2001544973 @default.
• W2910865326 cites W2002583936 @default.
• W2910865326 cites W2009914667 @default.
• W2910865326 cites W2011120858 @default.
• W2910865326 cites W2019927715 @default.
• W2910865326 cites W2020131167 @default.
• W2910865326 cites W2020702689 @default.
• W2910865326 cites W2022832076 @default.
• W2910865326 cites W2029535496 @default.
• W2910865326 cites W2034773856 @default.
• W2910865326 cites W2040385253 @default.
• W2910865326 cites W2058765546 @default.
• W2910865326 cites W2058943350 @default.
• W2910865326 cites W2060551076 @default.
• W2910865326 cites W2066343531 @default.
• W2910865326 cites W2078184757 @default.
• W2910865326 cites W2082475821 @default.
• W2910865326 cites W2082668371 @default.
• W2910865326 cites W2085858770 @default.
• W2910865326 cites W2090517643 @default.
• W2910865326 cites W2092717233 @default.
• W2910865326 cites W2101093124 @default.
• W2910865326 cites W2118611462 @default.
• W2910865326 cites W2121619780 @default.
• W2910865326 cites W2123508600 @default.
• W2910865326 cites W2129361250 @default.
• W2910865326 cites W2130503287 @default.
• W2910865326 cites W2133792559 @default.
• W2910865326 cites W2134199670 @default.
• W2910865326 cites W2139948451 @default.
• W2910865326 cites W2142052119 @default.
• W2910865326 cites W2147673571 @default.
• W2910865326 cites W2158228067 @default.
• W2910865326 cites W2158955581 @default.
• W2910865326 cites W2167414381 @default.
• W2910865326 cites W2189135309 @default.
• W2910865326 cites W2252688218 @default.
• W2910865326 cites W2332590084 @default.
• W2910865326 cites W2345174795 @default.
• W2910865326 cites W2479394673 @default.
• W2910865326 cites W2509221727 @default.
• W2910865326 cites W2526011086 @default.
• W2910865326 cites W2564692361 @default.
• W2910865326 cites W2576290078 @default.
• W2910865326 cites W2591548847 @default.
• W2910865326 cites W2624666184 @default.
• W2910865326 cites W2730615870 @default.
• W2910865326 cites W2732045452 @default.
• W2910865326 cites W2737715184 @default.
• W2910865326 cites W2786301534 @default.
• W2910865326 cites W2807089693 @default.
• W2910865326 cites W2892723308 @default.
• W2910865326 cites W2895962744 @default.
• W2910865326 doi "https://doi.org/10.1111/jpi.12556" @default.
• W2910865326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30648757" @default.
• W2910865326 hasPublicationYear "2019" @default.
• W2910865326 type Work @default.
• W2910865326 sameAs 2910865326 @default.
• W2910865326 citedByCount "27" @default.
• W2910865326 countsByYear W29108653262019 @default.
• W2910865326 countsByYear W29108653262020 @default.
• W2910865326 countsByYear W29108653262021 @default.
• W2910865326 countsByYear W29108653262022 @default.
• W2910865326 countsByYear W29108653262023 @default.
• W2910865326 crossrefType "journal-article" @default.
• W2910865326 hasAuthorship W2910865326A5016029445 @default.
• W2910865326 hasAuthorship W2910865326A5028959139 @default.
• W2910865326 hasAuthorship W2910865326A5051356020 @default.
• W2910865326 hasAuthorship W2910865326A5054288237 @default.
• W2910865326 hasAuthorship W2910865326A5059663288 @default.
• W2910865326 hasAuthorship W2910865326A5074994491 @default.
• W2910865326 hasAuthorship W2910865326A5078229246 @default.
• W2910865326 hasAuthorship W2910865326A5086752664 @default.
• W2910865326 hasConcept C104317684 @default.
• W2910865326 hasConcept C132647116 @default.

• next