FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910903021> ?p ?o ?g. }

• W2910903021 endingPage "354" @default.
• W2910903021 startingPage "343" @default.
• W2910903021 abstract "Abstract Aspirin showed both favorable efficacy and safety in the treatment of atherosclerosis (AS). This study aimed to explore the effects of Aspirin on AS treatment. Differentially expressed mRNAs in AS were screened out and visualized by R project. The mRNA expression levels of NFκB1 and its targets were detected by qRT‐PCR. The protein expression levels of NFκB1 , intercellular cell adhesion molecule‐1 ( ICAM1 ) and vascular cell adhesion molecule‐1 ( VCAM1 ) were detected by western blot analysis. Besides, CCK‐8 and flow cytometry assay were employed to evaluate the effects of Aspirin on cell proliferation rate and cell apoptotic rate respectively. Mouse model of AS was established for the verification of Aspirin‐mediated suppression of AS progression in vivo. NFκB1 and Anti‐Mullerian Hormone ( AMH ) were both over‐expressed in atherosclerotic femoral artery tissues compared with healthy femoral artery tissues. cAMP signaling pathway was activated in AS. Overexpression of NFκB1 largely increased cell proliferation rate of VSMCs, which was instead down‐regulated with suppression of NFκB1 in AS. By contrast, down‐regulation of NFκB1 greatly increased cell apoptotic rate of VSMCs, which was otherwise reversed with up‐regulation of NFκB1 in AS. It was proved that Aspirin increased cell apoptotic rate yet decreased cell proliferation rate of VSMCs to suppress AS progression by down‐regulating the expression of NFκB1 and its targets, which might well provide us with more therapeutic strategies for treatment of AS. © 2019 BioFactors, 45(3):343–354, 2019" @default.
• W2910903021 created "2019-01-25" @default.
• W2910903021 creator A5011241874 @default.
• W2910903021 creator A5012928916 @default.
• W2910903021 creator A5017359407 @default.
• W2910903021 creator A5039038654 @default.
• W2910903021 creator A5045673750 @default.
• W2910903021 creator A5067028141 @default.
• W2910903021 date "2019-01-11" @default.
• W2910903021 modified "2023-10-14" @default.
• W2910903021 title "Aspirin suppresses <i>NFκB1</i> expression and inactivates cAMP signaling pathway to treat atherosclerosis" @default.
• W2910903021 cites W1965174960 @default.
• W2910903021 cites W1998812648 @default.
• W2910903021 cites W2015479343 @default.
• W2910903021 cites W2040942777 @default.
• W2910903021 cites W2083063101 @default.
• W2910903021 cites W2106275588 @default.
• W2910903021 cites W2120047761 @default.
• W2910903021 cites W2140602939 @default.
• W2910903021 cites W2154695292 @default.
• W2910903021 cites W2172025984 @default.
• W2910903021 cites W2174939247 @default.
• W2910903021 cites W2183298799 @default.
• W2910903021 cites W2320306576 @default.
• W2910903021 cites W2415974967 @default.
• W2910903021 cites W2475254585 @default.
• W2910903021 cites W2566405197 @default.
• W2910903021 cites W2749380187 @default.
• W2910903021 cites W2767318893 @default.
• W2910903021 cites W2768520049 @default.
• W2910903021 cites W2773170895 @default.
• W2910903021 doi "https://doi.org/10.1002/biof.1487" @default.
• W2910903021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30633827" @default.
• W2910903021 hasPublicationYear "2019" @default.
• W2910903021 type Work @default.
• W2910903021 sameAs 2910903021 @default.
• W2910903021 citedByCount "6" @default.
• W2910903021 countsByYear W29109030212019 @default.
• W2910903021 countsByYear W29109030212020 @default.
• W2910903021 countsByYear W29109030212021 @default.
• W2910903021 countsByYear W29109030212022 @default.
• W2910903021 crossrefType "journal-article" @default.
• W2910903021 hasAuthorship W2910903021A5011241874 @default.
• W2910903021 hasAuthorship W2910903021A5012928916 @default.
• W2910903021 hasAuthorship W2910903021A5017359407 @default.
• W2910903021 hasAuthorship W2910903021A5039038654 @default.
• W2910903021 hasAuthorship W2910903021A5045673750 @default.
• W2910903021 hasAuthorship W2910903021A5067028141 @default.
• W2910903021 hasConcept C104317684 @default.
• W2910903021 hasConcept C126322002 @default.
• W2910903021 hasConcept C1491633281 @default.
• W2910903021 hasConcept C153911025 @default.
• W2910903021 hasConcept C16224149 @default.
• W2910903021 hasConcept C185592680 @default.
• W2910903021 hasConcept C190283241 @default.
• W2910903021 hasConcept C2776415932 @default.
• W2910903021 hasConcept C2777628954 @default.
• W2910903021 hasConcept C502942594 @default.
• W2910903021 hasConcept C553184892 @default.
• W2910903021 hasConcept C55493867 @default.
• W2910903021 hasConcept C62112901 @default.
• W2910903021 hasConcept C62478195 @default.
• W2910903021 hasConcept C71924100 @default.
• W2910903021 hasConcept C85789140 @default.
• W2910903021 hasConcept C86803240 @default.
• W2910903021 hasConcept C95444343 @default.
• W2910903021 hasConceptScore W2910903021C104317684 @default.
• W2910903021 hasConceptScore W2910903021C126322002 @default.
• W2910903021 hasConceptScore W2910903021C1491633281 @default.
• W2910903021 hasConceptScore W2910903021C153911025 @default.
• W2910903021 hasConceptScore W2910903021C16224149 @default.
• W2910903021 hasConceptScore W2910903021C185592680 @default.
• W2910903021 hasConceptScore W2910903021C190283241 @default.
• W2910903021 hasConceptScore W2910903021C2776415932 @default.
• W2910903021 hasConceptScore W2910903021C2777628954 @default.
• W2910903021 hasConceptScore W2910903021C502942594 @default.
• W2910903021 hasConceptScore W2910903021C553184892 @default.
• W2910903021 hasConceptScore W2910903021C55493867 @default.
• W2910903021 hasConceptScore W2910903021C62112901 @default.
• W2910903021 hasConceptScore W2910903021C62478195 @default.
• W2910903021 hasConceptScore W2910903021C71924100 @default.
• W2910903021 hasConceptScore W2910903021C85789140 @default.
• W2910903021 hasConceptScore W2910903021C86803240 @default.
• W2910903021 hasConceptScore W2910903021C95444343 @default.
• W2910903021 hasFunder F4320321001 @default.
• W2910903021 hasIssue "3" @default.
• W2910903021 hasLocation W29109030211 @default.
• W2910903021 hasLocation W29109030212 @default.
• W2910903021 hasOpenAccess W2910903021 @default.
• W2910903021 hasPrimaryLocation W29109030211 @default.
• W2910903021 hasRelatedWork W2350294409 @default.
• W2910903021 hasRelatedWork W2354128257 @default.
• W2910903021 hasRelatedWork W2354735832 @default.
• W2910903021 hasRelatedWork W2369710241 @default.
• W2910903021 hasRelatedWork W2371611592 @default.
• W2910903021 hasRelatedWork W2382230817 @default.
• W2910903021 hasRelatedWork W2386702156 @default.
• W2910903021 hasRelatedWork W2390161229 @default.

• next