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- W2910921444 abstract "Background The structural damage of RA usually develops within the first two years of disease and the risk of joint destruction is still difficult to predict1 Objectives To assess predictive value of the clinical, laboratory and echosonographic parameters activity of early RA in progression of structural damage in DMARDs/glucocorticoid naive patients in the first 6 months. Methods Sixty-five pts. (56 females, mean age 53±14.1 years) with early RA (EULAR/ACR 2010 criteria) and symptoms duration of ≤1 years. (mean duration of 3.6 months) were included during the 2012–14 years. and followed up 6 months. Patients were DMARDs/glicocorticoid naive and had no X-ray visible structural damage. The ESR, CRP, RF, ACPA and MMP3 were measured. DAS28 index was calculated. US assessment was performed blindly to patient‘s medical history, on the same day when early RA diagnosis was established and repeated after 6 months, using 18MHz linear probe by ESAOTE My Lab 70 machine. Presence of bone erosions and Power Doppler (PD) signal, were recorded at each hand‘s joint, as well as at MTP1–5 joints of both side, according to OMERACT US group definition. The semi quantitative method (0–3) was applied for assessing US synovitis and total Power Doppler joint score (TPDJs)/pts. was calculated. Results Fifty-nine pts. had finding of US bone erosions at baseline visit and 62 pts had it after 6 months. The significant increase of bone erosions and significant decrease of TPDJs/pts were found after follow-up (2.2. vs. 3.1 respectively; 10. vs. 4.5 respectively; Wilcoxon test: p Conclusions Initial finding of US bone erosion is the most important risk factor for progression of structural damage with our DMARDs/glucocorticoid naive early RA patients in the first 6 months of disease duration. Reference [1] Morel J, Combe B. How to predict prognosis in early rheumatoid arthritis. Best Pract Res Clin Rheumatol2005;19:137–46. Disclosure of Interest None declared" @default.
- W2910921444 created "2019-01-25" @default.
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- W2910921444 date "2018-06-01" @default.
- W2910921444 modified "2023-09-27" @default.
- W2910921444 title "AB0307 Predictive value of the baseline clinical, laboratory and echosonographic parameters of ra activity in progression of structural damage in dmards naÏve early ra patients – 6 months follow-up-" @default.
- W2910921444 doi "https://doi.org/10.1136/annrheumdis-2018-eular.3290" @default.
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