Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910960086> ?p ?o ?g. }
- W2910960086 endingPage "805" @default.
- W2910960086 startingPage "792" @default.
- W2910960086 abstract "Nine phenolic compounds were identified and quantified in Artocarpus altilia fruit. One of the main compounds was quercetin, which is the major class of flavonoids has been identified and quantified in pulp part of A. altilis fruit of methanol extract. The aim of this study was to evaluate in vitro cytotoxic assay. Inhibitory concentration 50% concentration was determined using trypan blue exclusion assay. Apoptosis induction and cell cycle regulation were studied by flow cytometric analysis. The expression of apoptosis and cell cycle-related regulatory genes were assessed by RT-qPCR study of the methanol extract of pulp part on human lung carcinoma (A549) cell line. A significant increase of cells at G2/M phases was detected (P < 0.05). Furthermore, the pulp of the fruit downregulated the expression of anti-apoptosis gene BCL-2 and upregulated the expression of pro-apoptosis gene BAX. CASPASE-3 was also activated by the fruit, which started a CASPASE-3-depended mitochondrial pathway to induce apoptosis. As the results, the pulp was the most active in terms of all tests, due to high amount of quercetin in pulp part, 78% of total flavonoids. Taken together, these findings suggested that A. altilis induces apoptosis in a mitochondrial-dependent pathway by releasing and upregulating CYTOCHROME C expression and regulates the expression of downstream apoptotic components, including BCL-2 and BAX." @default.
- W2910960086 created "2019-01-25" @default.
- W2910960086 creator A5013836699 @default.
- W2910960086 creator A5022120499 @default.
- W2910960086 creator A5032888100 @default.
- W2910960086 creator A5055959590 @default.
- W2910960086 creator A5064396637 @default.
- W2910960086 creator A5067480979 @default.
- W2910960086 creator A5068580378 @default.
- W2910960086 creator A5078485286 @default.
- W2910960086 creator A5087629620 @default.
- W2910960086 date "2019-01-07" @default.
- W2910960086 modified "2023-10-16" @default.
- W2910960086 title "Identification and Quantification of Quercetin, A Major Constituent of<i>Artocarpus altilis</i>by Targeting Related Genes of Apoptosis and Cell Cycle: In Vitro Cytotoxic Activity Against Human Lung Carcinoma Cell Lines" @default.
- W2910960086 cites W1660169007 @default.
- W2910960086 cites W1819288935 @default.
- W2910960086 cites W1913661233 @default.
- W2910960086 cites W1964703598 @default.
- W2910960086 cites W1965364041 @default.
- W2910960086 cites W1968068237 @default.
- W2910960086 cites W1969379155 @default.
- W2910960086 cites W1977733662 @default.
- W2910960086 cites W1979182110 @default.
- W2910960086 cites W1979221381 @default.
- W2910960086 cites W1980591003 @default.
- W2910960086 cites W1990293840 @default.
- W2910960086 cites W1993105044 @default.
- W2910960086 cites W1994694127 @default.
- W2910960086 cites W1995138694 @default.
- W2910960086 cites W1997219075 @default.
- W2910960086 cites W1997352661 @default.
- W2910960086 cites W1998612932 @default.
- W2910960086 cites W1999035710 @default.
- W2910960086 cites W2003300318 @default.
- W2910960086 cites W2008757142 @default.
- W2910960086 cites W2012137238 @default.
- W2910960086 cites W2023939312 @default.
- W2910960086 cites W2024173696 @default.
- W2910960086 cites W2026191935 @default.
- W2910960086 cites W2026413355 @default.
- W2910960086 cites W2027542963 @default.
- W2910960086 cites W2032440171 @default.
- W2910960086 cites W2034887257 @default.
- W2910960086 cites W2038570132 @default.
- W2910960086 cites W2038696352 @default.
- W2910960086 cites W2038911036 @default.
- W2910960086 cites W2042576623 @default.
- W2910960086 cites W2055054323 @default.
- W2910960086 cites W2057562982 @default.
- W2910960086 cites W2063839346 @default.
- W2910960086 cites W2065205296 @default.
- W2910960086 cites W2065679561 @default.
- W2910960086 cites W2068333952 @default.
- W2910960086 cites W2072594044 @default.
- W2910960086 cites W2073993854 @default.
- W2910960086 cites W2092746799 @default.
- W2910960086 cites W2093748380 @default.
- W2910960086 cites W2095058128 @default.
- W2910960086 cites W2111837850 @default.
- W2910960086 cites W2120600063 @default.
- W2910960086 cites W2120959748 @default.
- W2910960086 cites W2124259311 @default.
- W2910960086 cites W2134178487 @default.
- W2910960086 cites W2142802606 @default.
- W2910960086 cites W2144312770 @default.
- W2910960086 cites W2144868623 @default.
- W2910960086 cites W2147216274 @default.
- W2910960086 cites W2148083325 @default.
- W2910960086 cites W2148806087 @default.
- W2910960086 cites W2149188297 @default.
- W2910960086 cites W2152118923 @default.
- W2910960086 cites W2152247516 @default.
- W2910960086 cites W2152792277 @default.
- W2910960086 cites W2157935840 @default.
- W2910960086 cites W2161610573 @default.
- W2910960086 cites W2166484445 @default.
- W2910960086 cites W2167106423 @default.
- W2910960086 cites W2171968926 @default.
- W2910960086 cites W2235523093 @default.
- W2910960086 cites W2318272432 @default.
- W2910960086 cites W2594373254 @default.
- W2910960086 cites W2917837889 @default.
- W2910960086 cites W4230982340 @default.
- W2910960086 doi "https://doi.org/10.1080/01635581.2018.1516790" @default.
- W2910960086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30614285" @default.
- W2910960086 hasPublicationYear "2019" @default.
- W2910960086 type Work @default.
- W2910960086 sameAs 2910960086 @default.
- W2910960086 citedByCount "4" @default.
- W2910960086 countsByYear W29109600862020 @default.
- W2910960086 countsByYear W29109600862022 @default.
- W2910960086 countsByYear W29109600862023 @default.
- W2910960086 crossrefType "journal-article" @default.
- W2910960086 hasAuthorship W2910960086A5013836699 @default.
- W2910960086 hasAuthorship W2910960086A5022120499 @default.
- W2910960086 hasAuthorship W2910960086A5032888100 @default.
- W2910960086 hasAuthorship W2910960086A5055959590 @default.
- W2910960086 hasAuthorship W2910960086A5064396637 @default.