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- W2911001448 abstract "The aim of this paper is to study the theranostic potential of 5-Aminolevulinic Acid (5-ALA)in dentistry.Photodynamic inactivation (PDI) and fluorescence spectroscopy of Streptococcus sanguis, and laser induced fluorescence (LIF) of several decayed teeth were performed using 5-ALA.In the absence of 5-ALA, 15 min illumination of the bacteria by the means of an LED light source led to only 1.16% viability reduction. On the other hand, 5-ALA revealed remarkable dark toxicity at concentrations above 20 μM. Furthermore, the synergistic effects of 10 μM 5-ALA and illumination by the light source for 5 and 15 min intervals led respectivelyto0.74log10 and 1.69log10 reduction of viability. Also, fluorescence spectroscopy of the bacteria showed a direct relationship between emission line intensity at 620 nm and the concentration of 5-ALA. In dental experiments, following exposing tooth with 40 mM 5-ALA, a significant autofluorescence growth was observed just in the decayed parts.Based on the strong dual modality of 5-ALA to annihilate cariogenic bacteria through photodynamic inactivation and enhancing LIF intensity for identification of dental caries, 5-ALA is proposed as a theranostic agent in dentistry." @default.
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- W2911001448 date "2019-03-01" @default.
- W2911001448 modified "2023-09-29" @default.
- W2911001448 title "Introduction of 5-aminolevulinic acid as a theranostics agent in dentistry" @default.
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- W2911001448 doi "https://doi.org/10.1016/j.pdpdt.2019.01.021" @default.
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