FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911038963> ?p ?o ?g. }

• W2911038963 endingPage "e0210585" @default.
• W2911038963 startingPage "e0210585" @default.
• W2911038963 abstract "Objective Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability of plasma growth differentiation factor 15 (GDF-15) as a marker for recurrent disease, as well as a marker for poor prognosis and lymph node metastases. Methods EDTA-blood samples were obtained from 235 patients with endometrial cancer before primary surgery. For 36 of these patients, matching blood samples were collected at time of recurrence. Blood samples were also collected from 78 patients with endometrial hyperplasia. Plasma GDF-15 was measured by an enzyme-linked immunosorbent assay (ELISA). Preoperative pelvic MRI scans for 141 patients were investigated in parallel for imaging variables. Results Preoperative plasma level of GDF-15 was significantly higher for patients who experienced recurrence (1780 ng/L; 95% CI; 518–9475 ng/L) than for patients who did not develop recurrent disease (1236 ng/L; 95% CI; 307–7030 ng/L) (p<0.001). Plasma levels of GDF-15 at recurrence (2818 ng/L, 95% CI 2088–3548 ng/L) were significantly higher than plasma levels of GDF-15 measured at time of primary diagnosis (1857 ng/L, 95% CI; 1317–2398 ng/L) (p = 0.001). High plasma level GDF-15 independently predicts recurrent disease (OR = 3.14; 95% CI 2.10–4.76) and lymph node metastases (OR = 2.64; 95% CI 1.52–4.61). Patients with high plasma level of GDF-15 had significantly larger tumor volume (p = 0.008). Conclusion Elevated plasma level of GDF-15 is associated with aggressive disease and lymph node metastasis in endometrial carcinoma. GDF-15 may be helpful in indicating recurrent disease." @default.
• W2911038963 created "2019-01-25" @default.
• W2911038963 creator A5012341647 @default.
• W2911038963 creator A5032174631 @default.
• W2911038963 creator A5035785989 @default.
• W2911038963 creator A5045128636 @default.
• W2911038963 creator A5051745771 @default.
• W2911038963 creator A5061157128 @default.
• W2911038963 creator A5079476137 @default.
• W2911038963 creator A5080010131 @default.
• W2911038963 date "2019-01-15" @default.
• W2911038963 modified "2023-09-24" @default.
• W2911038963 title "Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer" @default.
• W2911038963 cites W1852146320 @default.
• W2911038963 cites W1856760826 @default.
• W2911038963 cites W1975913194 @default.
• W2911038963 cites W1985058596 @default.
• W2911038963 cites W1995237066 @default.
• W2911038963 cites W2009115869 @default.
• W2911038963 cites W2014629059 @default.
• W2911038963 cites W2020474446 @default.
• W2911038963 cites W2043356536 @default.
• W2911038963 cites W2044611221 @default.
• W2911038963 cites W2047613631 @default.
• W2911038963 cites W2051891844 @default.
• W2911038963 cites W2063381057 @default.
• W2911038963 cites W2074347687 @default.
• W2911038963 cites W2078910663 @default.
• W2911038963 cites W2097231959 @default.
• W2911038963 cites W2108324242 @default.
• W2911038963 cites W2109560931 @default.
• W2911038963 cites W2121316141 @default.
• W2911038963 cites W2129218179 @default.
• W2911038963 cites W2132870799 @default.
• W2911038963 cites W21356552 @default.
• W2911038963 cites W2142644563 @default.
• W2911038963 cites W2154442758 @default.
• W2911038963 cites W2168430622 @default.
• W2911038963 cites W2741017563 @default.
• W2911038963 cites W2741780384 @default.
• W2911038963 cites W2766627198 @default.
• W2911038963 cites W2790369258 @default.
• W2911038963 cites W4211047904 @default.
• W2911038963 doi "https://doi.org/10.1371/journal.pone.0210585" @default.
• W2911038963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333370" @default.
• W2911038963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30645608" @default.
• W2911038963 hasPublicationYear "2019" @default.
• W2911038963 type Work @default.
• W2911038963 sameAs 2911038963 @default.
• W2911038963 citedByCount "7" @default.
• W2911038963 countsByYear W29110389632020 @default.
• W2911038963 countsByYear W29110389632021 @default.
• W2911038963 countsByYear W29110389632022 @default.
• W2911038963 crossrefType "journal-article" @default.
• W2911038963 hasAuthorship W2911038963A5012341647 @default.
• W2911038963 hasAuthorship W2911038963A5032174631 @default.
• W2911038963 hasAuthorship W2911038963A5035785989 @default.
• W2911038963 hasAuthorship W2911038963A5045128636 @default.
• W2911038963 hasAuthorship W2911038963A5051745771 @default.
• W2911038963 hasAuthorship W2911038963A5061157128 @default.
• W2911038963 hasAuthorship W2911038963A5079476137 @default.
• W2911038963 hasAuthorship W2911038963A5080010131 @default.
• W2911038963 hasBestOaLocation W29110389631 @default.
• W2911038963 hasConcept C121608353 @default.
• W2911038963 hasConcept C126322002 @default.
• W2911038963 hasConcept C136935669 @default.
• W2911038963 hasConcept C143998085 @default.
• W2911038963 hasConcept C2775904963 @default.
• W2911038963 hasConcept C2777088508 @default.
• W2911038963 hasConcept C2777546739 @default.
• W2911038963 hasConcept C2780849966 @default.
• W2911038963 hasConcept C71924100 @default.
• W2911038963 hasConcept C90924648 @default.
• W2911038963 hasConceptScore W2911038963C121608353 @default.
• W2911038963 hasConceptScore W2911038963C126322002 @default.
• W2911038963 hasConceptScore W2911038963C136935669 @default.
• W2911038963 hasConceptScore W2911038963C143998085 @default.
• W2911038963 hasConceptScore W2911038963C2775904963 @default.
• W2911038963 hasConceptScore W2911038963C2777088508 @default.
• W2911038963 hasConceptScore W2911038963C2777546739 @default.
• W2911038963 hasConceptScore W2911038963C2780849966 @default.
• W2911038963 hasConceptScore W2911038963C71924100 @default.
• W2911038963 hasConceptScore W2911038963C90924648 @default.
• W2911038963 hasFunder F4320310758 @default.
• W2911038963 hasFunder F4320323299 @default.
• W2911038963 hasIssue "1" @default.
• W2911038963 hasLocation W29110389631 @default.
• W2911038963 hasLocation W29110389632 @default.
• W2911038963 hasLocation W29110389633 @default.
• W2911038963 hasLocation W29110389634 @default.
• W2911038963 hasLocation W29110389635 @default.
• W2911038963 hasOpenAccess W2911038963 @default.
• W2911038963 hasPrimaryLocation W29110389631 @default.
• W2911038963 hasRelatedWork W2098643742 @default.
• W2911038963 hasRelatedWork W2187081491 @default.
• W2911038963 hasRelatedWork W2375371441 @default.
• W2911038963 hasRelatedWork W2413118717 @default.
• W2911038963 hasRelatedWork W2774126578 @default.

• next