FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911053165> ?p ?o ?g. }

• W2911053165 endingPage "425" @default.
• W2911053165 startingPage "425" @default.
• W2911053165 abstract "Background: The molecular signature of endometrial receptivity still remains barely understood, especially when focused on the possible benefit of therapeutical interventions and implantation-related pathologies. Therefore, the protein composition of tissue and isolated primary cells (endometrial stromal cells, ESCs) from endometrial scratchings of ART (Assisted Reproductive Techniques) patients with repeated implantation failure (RIF) was compared to volunteers with proven fertility during the time of embryo implantation (LH + 7). Furthermore, an analysis of the endometrial tissue of fertile women infused with human chorionic gonadotropin (hCG) was conducted. Methods: Endometrial samples (n = 6 RIF, n = 10 fertile controls) were split into 3 pieces: 1/3 each was frozen in liquid nitrogen, 1/3 fixed in PFA and 1/3 cultured. Protein lysates prepared from fresh frozen tissue were processed for mass spectrometric analysis. Results: Three proteins (EPPK1, BCLAF1 and PTMA) showed a statistically altered abundance in the endometrial tissue of RIF patients. Furthermore, pathways like metabolism, immune system, ferroptosis and the endoplasmic reticulum were altered in RIF patients. Remarkably, endometrial tissues of RIF patients showed a significantly higher (p-value = 9 × 10−8) protein intensity correlation (Pearson’s correlation coefficient = 0.95) compared to fertile women (Pearson’s correlation coefficient = 0.88). The in vivo infusion of hCG stimulated proteins of endocytosis, HIF1 signalling and chemokine production. Notably, patients suffering from RIF had a clinical pregnancy rate of 19% after the intrauterine infusion of hCG before embryo transfer (ET) compared to their failed previous cycles. Conclusion: Our study showed for the first time that the endometrial proteome composition of RIF patients differs from fertile controls during the window of implantation. The intrauterine infusion of hCG prior to an embryo transfer might improve the chemokine triggered embryo-endometrial dialogue and intensify the angiogenesis and immune response. From a clinical point of view, the hCG infusion prior to an embryo transfer might increase the pregnancy rate of RIF patients." @default.
• W2911053165 created "2019-01-25" @default.
• W2911053165 creator A5001979794 @default.
• W2911053165 creator A5011794669 @default.
• W2911053165 creator A5026683205 @default.
• W2911053165 creator A5076984925 @default.
• W2911053165 creator A5080638400 @default.
• W2911053165 creator A5085030806 @default.
• W2911053165 date "2019-01-19" @default.
• W2911053165 modified "2023-10-18" @default.
• W2911053165 title "A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level–Does hCG Render the Endometrium of RIF Patients?" @default.
• W2911053165 cites W1966272465 @default.
• W2911053165 cites W1978918749 @default.
• W2911053165 cites W1988659813 @default.
• W2911053165 cites W1990044641 @default.
• W2911053165 cites W2008135772 @default.
• W2911053165 cites W2009850323 @default.
• W2911053165 cites W2019378351 @default.
• W2911053165 cites W2026123671 @default.
• W2911053165 cites W2035705613 @default.
• W2911053165 cites W2045546001 @default.
• W2911053165 cites W2052734212 @default.
• W2911053165 cites W2054800959 @default.
• W2911053165 cites W2062005949 @default.
• W2911053165 cites W2064804626 @default.
• W2911053165 cites W2069902854 @default.
• W2911053165 cites W2071090120 @default.
• W2911053165 cites W2092883267 @default.
• W2911053165 cites W2108088511 @default.
• W2911053165 cites W2111334470 @default.
• W2911053165 cites W2117371378 @default.
• W2911053165 cites W2124381929 @default.
• W2911053165 cites W2130126684 @default.
• W2911053165 cites W2136488022 @default.
• W2911053165 cites W2157795344 @default.
• W2911053165 cites W2158472102 @default.
• W2911053165 cites W2344520158 @default.
• W2911053165 cites W2400783197 @default.
• W2911053165 cites W2534254897 @default.
• W2911053165 cites W2560277911 @default.
• W2911053165 cites W2561667785 @default.
• W2911053165 cites W2582792555 @default.
• W2911053165 cites W2621406766 @default.
• W2911053165 cites W2704749925 @default.
• W2911053165 cites W2768550879 @default.
• W2911053165 cites W2788509085 @default.
• W2911053165 cites W2894684045 @default.
• W2911053165 cites W4294107304 @default.
• W2911053165 doi "https://doi.org/10.3390/ijms20020425" @default.
• W2911053165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6358950" @default.
• W2911053165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30669470" @default.
• W2911053165 hasPublicationYear "2019" @default.
• W2911053165 type Work @default.
• W2911053165 sameAs 2911053165 @default.
• W2911053165 citedByCount "25" @default.
• W2911053165 countsByYear W29110531652019 @default.
• W2911053165 countsByYear W29110531652020 @default.
• W2911053165 countsByYear W29110531652021 @default.
• W2911053165 countsByYear W29110531652022 @default.
• W2911053165 countsByYear W29110531652023 @default.
• W2911053165 crossrefType "journal-article" @default.
• W2911053165 hasAuthorship W2911053165A5001979794 @default.
• W2911053165 hasAuthorship W2911053165A5011794669 @default.
• W2911053165 hasAuthorship W2911053165A5026683205 @default.
• W2911053165 hasAuthorship W2911053165A5076984925 @default.
• W2911053165 hasAuthorship W2911053165A5080638400 @default.
• W2911053165 hasAuthorship W2911053165A5085030806 @default.
• W2911053165 hasBestOaLocation W29110531651 @default.
• W2911053165 hasConcept C126322002 @default.
• W2911053165 hasConcept C134018914 @default.
• W2911053165 hasConcept C160099875 @default.
• W2911053165 hasConcept C16685009 @default.
• W2911053165 hasConcept C16930146 @default.
• W2911053165 hasConcept C196843134 @default.
• W2911053165 hasConcept C2779742232 @default.
• W2911053165 hasConcept C71924100 @default.
• W2911053165 hasConcept C86803240 @default.
• W2911053165 hasConcept C95444343 @default.
• W2911053165 hasConceptScore W2911053165C126322002 @default.
• W2911053165 hasConceptScore W2911053165C134018914 @default.
• W2911053165 hasConceptScore W2911053165C160099875 @default.
• W2911053165 hasConceptScore W2911053165C16685009 @default.
• W2911053165 hasConceptScore W2911053165C16930146 @default.
• W2911053165 hasConceptScore W2911053165C196843134 @default.
• W2911053165 hasConceptScore W2911053165C2779742232 @default.
• W2911053165 hasConceptScore W2911053165C71924100 @default.
• W2911053165 hasConceptScore W2911053165C86803240 @default.
• W2911053165 hasConceptScore W2911053165C95444343 @default.
• W2911053165 hasFunder F4320320879 @default.
• W2911053165 hasFunder F4320321723 @default.
• W2911053165 hasIssue "2" @default.
• W2911053165 hasLocation W29110531651 @default.
• W2911053165 hasLocation W29110531652 @default.
• W2911053165 hasLocation W29110531653 @default.
• W2911053165 hasLocation W29110531654 @default.
• W2911053165 hasLocation W29110531655 @default.
• W2911053165 hasOpenAccess W2911053165 @default.
• W2911053165 hasPrimaryLocation W29110531651 @default.

• next