Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911099454> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2911099454 endingPage "10462" @default.
- W2911099454 startingPage "10452" @default.
- W2911099454 abstract "Abstract This study aims to investigate the role of long noncoding RNA (lncRNA) long intergenic nonprotein coding RNA 339 (LINC00339) in regulating renal tubular epithelial pyroptosis in kidney stones and to explore the underlying mechanism. The human renal proximal tubular epithelial (HK‐2) cells were treated with calcium oxalate monohydrate (COM) for 72 hours to establish the cell model of renal tubular injury. Relative expression of LINC00339 and miR‐22‐3p was measured by real‐time quantitative reverse transcription polymerase chain reaction. Expression of pyroptosis‐related molecules was measured by Western blot analysis (NLRP3, ASC, and cleaved caspase‐1 p10) and enzyme‐linked immunosorbent assay (interleukin‐1β [IL‐1β] and IL‐18). Pyroptosis was also determined by lactate dehydrogenase release and active caspase‐1‐propidium iodide double staining. Luciferase reporter assays were performed to verify whether miR‐22‐3p could bind to LINC00339 or NLRP3. We observed increased LINC00339, decreased miR‐22‐3p, NLRP3 inflammasome activation, and enhanced cell pyroptosis in COM‐treated HK‐2 cells. Furthermore, overexpression of both LINC00339 and NLRP3 activated NLRP3 inflammasome and promoted pyroptosis in COM‐treated HK‐2 cells, whereas miR‐22‐3p mimic and NLRP3 knockdown exerted the opposite effects. Mechanically, LINC00339 functioned as a competitive endogenous RNA by sponging miR‐22‐3p to facilitate NLRP3 expression. In conclusion, lncRNA LINC00339 promotes cell pyroptosis by sponging miR‐22‐3p to regulate NLRP3 expression in COM‐treated HK‐2 cells." @default.
- W2911099454 created "2019-01-25" @default.
- W2911099454 creator A5010361739 @default.
- W2911099454 creator A5015101931 @default.
- W2911099454 creator A5025160212 @default.
- W2911099454 creator A5040629535 @default.
- W2911099454 creator A5060211637 @default.
- W2911099454 creator A5083417334 @default.
- W2911099454 date "2019-01-04" @default.
- W2911099454 modified "2023-10-05" @default.
- W2911099454 title "Long noncoding RNA LINC00339 promotes renal tubular epithelial pyroptosis by regulating the miR‐22‐3p/NLRP3 axis in calcium oxalate–induced kidney stone" @default.
- W2911099454 cites W1521734634 @default.
- W2911099454 cites W1733354589 @default.
- W2911099454 cites W1970079622 @default.
- W2911099454 cites W1973171955 @default.
- W2911099454 cites W2013907285 @default.
- W2911099454 cites W2316864196 @default.
- W2911099454 cites W2343492981 @default.
- W2911099454 cites W2559904084 @default.
- W2911099454 cites W2564307932 @default.
- W2911099454 cites W2581822489 @default.
- W2911099454 cites W2761624970 @default.
- W2911099454 cites W2765744146 @default.
- W2911099454 cites W2769321903 @default.
- W2911099454 cites W2774010948 @default.
- W2911099454 cites W2789376643 @default.
- W2911099454 cites W2799720530 @default.
- W2911099454 cites W2808524309 @default.
- W2911099454 cites W2808548488 @default.
- W2911099454 cites W2809462102 @default.
- W2911099454 cites W2883440661 @default.
- W2911099454 cites W2884367722 @default.
- W2911099454 cites W2884664850 @default.
- W2911099454 cites W2886870513 @default.
- W2911099454 doi "https://doi.org/10.1002/jcb.28330" @default.
- W2911099454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30614043" @default.
- W2911099454 hasPublicationYear "2019" @default.
- W2911099454 type Work @default.
- W2911099454 sameAs 2911099454 @default.
- W2911099454 citedByCount "43" @default.
- W2911099454 countsByYear W29110994542019 @default.
- W2911099454 countsByYear W29110994542020 @default.
- W2911099454 countsByYear W29110994542021 @default.
- W2911099454 countsByYear W29110994542022 @default.
- W2911099454 countsByYear W29110994542023 @default.
- W2911099454 crossrefType "journal-article" @default.
- W2911099454 hasAuthorship W2911099454A5010361739 @default.
- W2911099454 hasAuthorship W2911099454A5015101931 @default.
- W2911099454 hasAuthorship W2911099454A5025160212 @default.
- W2911099454 hasAuthorship W2911099454A5040629535 @default.
- W2911099454 hasAuthorship W2911099454A5060211637 @default.
- W2911099454 hasAuthorship W2911099454A5083417334 @default.
- W2911099454 hasConcept C153911025 @default.
- W2911099454 hasConcept C170493617 @default.
- W2911099454 hasConcept C17172800 @default.
- W2911099454 hasConcept C173396325 @default.
- W2911099454 hasConcept C185592680 @default.
- W2911099454 hasConcept C190283241 @default.
- W2911099454 hasConcept C2775934118 @default.
- W2911099454 hasConcept C2777209026 @default.
- W2911099454 hasConcept C31573885 @default.
- W2911099454 hasConcept C55493867 @default.
- W2911099454 hasConcept C86803240 @default.
- W2911099454 hasConcept C95444343 @default.
- W2911099454 hasConceptScore W2911099454C153911025 @default.
- W2911099454 hasConceptScore W2911099454C170493617 @default.
- W2911099454 hasConceptScore W2911099454C17172800 @default.
- W2911099454 hasConceptScore W2911099454C173396325 @default.
- W2911099454 hasConceptScore W2911099454C185592680 @default.
- W2911099454 hasConceptScore W2911099454C190283241 @default.
- W2911099454 hasConceptScore W2911099454C2775934118 @default.
- W2911099454 hasConceptScore W2911099454C2777209026 @default.
- W2911099454 hasConceptScore W2911099454C31573885 @default.
- W2911099454 hasConceptScore W2911099454C55493867 @default.
- W2911099454 hasConceptScore W2911099454C86803240 @default.
- W2911099454 hasConceptScore W2911099454C95444343 @default.
- W2911099454 hasIssue "6" @default.
- W2911099454 hasLocation W29110994541 @default.
- W2911099454 hasLocation W29110994542 @default.
- W2911099454 hasOpenAccess W2911099454 @default.
- W2911099454 hasPrimaryLocation W29110994541 @default.
- W2911099454 hasRelatedWork W1905548644 @default.
- W2911099454 hasRelatedWork W2770925055 @default.
- W2911099454 hasRelatedWork W2968698979 @default.
- W2911099454 hasRelatedWork W2972371855 @default.
- W2911099454 hasRelatedWork W3090097156 @default.
- W2911099454 hasRelatedWork W3159951980 @default.
- W2911099454 hasRelatedWork W4213072117 @default.
- W2911099454 hasRelatedWork W4309885264 @default.
- W2911099454 hasRelatedWork W4380987475 @default.
- W2911099454 hasRelatedWork W4383481577 @default.
- W2911099454 hasVolume "120" @default.
- W2911099454 isParatext "false" @default.
- W2911099454 isRetracted "false" @default.
- W2911099454 magId "2911099454" @default.
- W2911099454 workType "article" @default.