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- W2911127775 endingPage "67" @default.
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- W2911127775 abstract "Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly understood and simple model organisms, such as yeast, have proved valuable to provide a more comprehensive view of the metabolic consequences caused by the identified mutations. In this review, we present results obtained with the yeast Saccharomyces cerevisiae to exemplify how a eukaryotic unicellular organism can offer highly relevant information for identifying the molecular basis of complex human diseases. Overall, purine metabolism illustrates a remarkable conservation of genes, functions and phenotypes between humans and yeast." @default.
- W2911127775 created "2019-01-25" @default.
- W2911127775 creator A5083989677 @default.
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- W2911127775 date "2019-01-17" @default.
- W2911127775 modified "2023-10-17" @default.
- W2911127775 title "Yeast to Study Human Purine Metabolism Diseases" @default.
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- W2911127775 doi "https://doi.org/10.3390/cells8010067" @default.
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