Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911131718> ?p ?o ?g. }
- W2911131718 endingPage "e13974" @default.
- W2911131718 startingPage "e13974" @default.
- W2911131718 abstract "Mechanical signals within contracting skeletal muscles contribute to the generation of the exercise pressor reflex; an important autonomic and cardiovascular control mechanism. In decerebrate rats, the mechanically activated channel inhibitor GsMTx4 was found to reduce the pressor response during static hindlimb muscle stretch; a maneuver used to investigate specifically the mechanical component of the exercise pressor reflex (i.e., the mechanoreflex). However, the effect was found only during the initial phase of the stretch when muscle length was changing and not during the later phase of stretch when muscle length was relatively constant. We tested the hypothesis that in decerebrate, unanesthetized rats, GsMTx4 would reduce the pressor response throughout the duration of a 30 sec, 1 Hz dynamic hindlimb muscle stretch protocol that produced repetitive changes in muscle length. We found that the injection of 10 μg of GsMTx4 into the arterial supply of a hindlimb reduced the peak pressor response (control: 15 ± 4, GsMTx4: 5 ± 2 mmHg, P < 0.05, n = 8) and the pressor response at multiple time points throughout the duration of the stretch. GsMTx4 had no effect on the pressor response to the hindlimb arterial injection of lactic acid which indicates the lack of local off-target effects. Combined with the recent finding that GsMTx4 reduced the pressor response only initially during static stretch in decerebrate rats, the present findings suggest that GsMTx4-sensitive channels respond primarily to mechanical signals associated with changes in muscle length. The findings add to our currently limited understanding of the channels that contribute to the activation of the mechanoreflex." @default.
- W2911131718 created "2019-01-25" @default.
- W2911131718 creator A5008975570 @default.
- W2911131718 creator A5025464587 @default.
- W2911131718 creator A5046669398 @default.
- W2911131718 creator A5050219518 @default.
- W2911131718 creator A5062158638 @default.
- W2911131718 creator A5084838385 @default.
- W2911131718 creator A5084918401 @default.
- W2911131718 date "2019-01-01" @default.
- W2911131718 modified "2023-09-25" @default.
- W2911131718 title "GsMTx4 reduces the reflex pressor response during dynamic hindlimb skeletal muscle stretch in decerebrate rats" @default.
- W2911131718 cites W1488574749 @default.
- W2911131718 cites W1489862134 @default.
- W2911131718 cites W1494236935 @default.
- W2911131718 cites W1777799823 @default.
- W2911131718 cites W1897241986 @default.
- W2911131718 cites W1972071814 @default.
- W2911131718 cites W1975319165 @default.
- W2911131718 cites W1981959501 @default.
- W2911131718 cites W1982712485 @default.
- W2911131718 cites W1987270666 @default.
- W2911131718 cites W1996505238 @default.
- W2911131718 cites W1999720993 @default.
- W2911131718 cites W2009712189 @default.
- W2911131718 cites W2023008505 @default.
- W2911131718 cites W2064802724 @default.
- W2911131718 cites W2071453006 @default.
- W2911131718 cites W2095971269 @default.
- W2911131718 cites W2099955260 @default.
- W2911131718 cites W2108652316 @default.
- W2911131718 cites W2110880731 @default.
- W2911131718 cites W2117352997 @default.
- W2911131718 cites W2118250164 @default.
- W2911131718 cites W2118624477 @default.
- W2911131718 cites W2127090556 @default.
- W2911131718 cites W2127767982 @default.
- W2911131718 cites W2143015249 @default.
- W2911131718 cites W2154550978 @default.
- W2911131718 cites W2160114990 @default.
- W2911131718 cites W2164925848 @default.
- W2911131718 cites W2172701815 @default.
- W2911131718 cites W2176489849 @default.
- W2911131718 cites W2176907467 @default.
- W2911131718 cites W2260154469 @default.
- W2911131718 cites W2292316672 @default.
- W2911131718 cites W2300486354 @default.
- W2911131718 cites W2413193617 @default.
- W2911131718 cites W2422180038 @default.
- W2911131718 cites W2556560434 @default.
- W2911131718 cites W2575510219 @default.
- W2911131718 cites W2604491532 @default.
- W2911131718 cites W2765742375 @default.
- W2911131718 cites W2803289311 @default.
- W2911131718 cites W4239435043 @default.
- W2911131718 cites W4254840356 @default.
- W2911131718 doi "https://doi.org/10.14814/phy2.13974" @default.
- W2911131718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6328922" @default.
- W2911131718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30632294" @default.
- W2911131718 hasPublicationYear "2019" @default.
- W2911131718 type Work @default.
- W2911131718 sameAs 2911131718 @default.
- W2911131718 citedByCount "14" @default.
- W2911131718 countsByYear W29111317182019 @default.
- W2911131718 countsByYear W29111317182020 @default.
- W2911131718 countsByYear W29111317182021 @default.
- W2911131718 countsByYear W29111317182023 @default.
- W2911131718 crossrefType "journal-article" @default.
- W2911131718 hasAuthorship W2911131718A5008975570 @default.
- W2911131718 hasAuthorship W2911131718A5025464587 @default.
- W2911131718 hasAuthorship W2911131718A5046669398 @default.
- W2911131718 hasAuthorship W2911131718A5050219518 @default.
- W2911131718 hasAuthorship W2911131718A5062158638 @default.
- W2911131718 hasAuthorship W2911131718A5084838385 @default.
- W2911131718 hasAuthorship W2911131718A5084918401 @default.
- W2911131718 hasBestOaLocation W29111317181 @default.
- W2911131718 hasConcept C126322002 @default.
- W2911131718 hasConcept C134018914 @default.
- W2911131718 hasConcept C185592680 @default.
- W2911131718 hasConcept C24998067 @default.
- W2911131718 hasConcept C2776050358 @default.
- W2911131718 hasConcept C2779959927 @default.
- W2911131718 hasConcept C2909417689 @default.
- W2911131718 hasConcept C3020056645 @default.
- W2911131718 hasConcept C42219234 @default.
- W2911131718 hasConcept C51738704 @default.
- W2911131718 hasConcept C71924100 @default.
- W2911131718 hasConcept C83974742 @default.
- W2911131718 hasConceptScore W2911131718C126322002 @default.
- W2911131718 hasConceptScore W2911131718C134018914 @default.
- W2911131718 hasConceptScore W2911131718C185592680 @default.
- W2911131718 hasConceptScore W2911131718C24998067 @default.
- W2911131718 hasConceptScore W2911131718C2776050358 @default.
- W2911131718 hasConceptScore W2911131718C2779959927 @default.
- W2911131718 hasConceptScore W2911131718C2909417689 @default.
- W2911131718 hasConceptScore W2911131718C3020056645 @default.
- W2911131718 hasConceptScore W2911131718C42219234 @default.
- W2911131718 hasConceptScore W2911131718C51738704 @default.