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- W2911145536 abstract "Although papillary thyroid carcinoma (PTC)-type nuclear changes are the most reliable morphological feature in the diagnosis of PTC, the nuclear assessment used to identify these changes is highly subjective. Here, we report a noninvasive encapsulated thyroid tumor with a papillary growth pattern measuring 23 mm at its largest diameter with a nuclear score of 2 in a 26-year-old man. After undergoing left lobectomy, the patient was diagnosed with an encapsulated PTC. However, a second opinion consultation suggested an alternative diagnosis of follicular adenoma with papillary hyperplasia. When providing a third opinion, we identified a low MIB-1 labeling index and a heterozygous point mutation in the KRAS gene but not the BRAF gene. We speculated that this case is an example of a novel borderline tumor with a papillary structure. Introduction of the new terminology noninvasive encapsulated papillary RAS-like thyroid tumor (NEPRAS) without the word cancer might relieve the psychological burden of patients in a way similar to the phrase noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)." @default.
- W2911145536 created "2019-01-25" @default.
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- W2911145536 date "2019-03-15" @default.
- W2911145536 modified "2023-09-24" @default.
- W2911145536 title "Encapsulated Papillary Thyroid Tumor with Delicate Nuclear Changes and a <i>KRAS</i> Mutation as a Possible Novel Subtype of Borderline Tumor" @default.
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- W2911145536 doi "https://doi.org/10.4132/jptm.2018.12.07" @default.
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