Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911210911> ?p ?o ?g. }
- W2911210911 abstract "Human hantavirus infections cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. No FDA-approved vaccines and therapeutics exist for these deadly viruses, and their development is limited by the requirement for high biocontainment. In this study, we identified and characterized key amino acid changes in the surface glycoproteins of HFRS-causing Hantaan virus that enhance their incorporation into recombinant vesicular stomatitis virus (rVSV) particles. The replication-competent rVSVs encoding Hantaan virus and Dobrava-Belgrade virus glycoproteins described in this work provide a powerful and facile system to study hantavirus entry under lower biocontainment and may have utility as hantavirus vaccines." @default.
- W2911210911 created "2019-01-25" @default.
- W2911210911 creator A5048815943 @default.
- W2911210911 creator A5072719273 @default.
- W2911210911 creator A5089260834 @default.
- W2911210911 date "2019-02-26" @default.
- W2911210911 modified "2023-10-09" @default.
- W2911210911 title "Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors" @default.
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- W2911210911 doi "https://doi.org/10.1128/mbio.02372-18" @default.
- W2911210911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6325249" @default.
- W2911210911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30622188" @default.
- W2911210911 hasPublicationYear "2019" @default.
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