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- W2911253006 abstract "Abstract During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study wound fibroblast diversity using single-cell RNA-sequencing. On analysis, wound fibroblasts group into twelve clusters. Pseudotime and RNA velocity analyses reveal that some clusters likely represent consecutive differentiation states toward a contractile phenotype, while others appear to represent distinct fibroblast lineages. One subset of fibroblasts expresses hematopoietic markers, suggesting their myeloid origin. We validate this finding using single-cell western blot and single-cell RNA-sequencing on genetically labeled myofibroblasts. Using bone marrow transplantation and Cre recombinase-based lineage tracing experiments, we rule out cell fusion events and confirm that hematopoietic lineage cells give rise to a subset of myofibroblasts and rare regenerated adipocytes. In conclusion, our study reveals that wounding induces a high degree of heterogeneity among fibroblasts and recruits highly plastic myeloid cells that contribute to adipocyte regeneration." @default.
- W2911253006 created "2019-02-21" @default.
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- W2911253006 date "2019-02-08" @default.
- W2911253006 modified "2023-10-18" @default.
- W2911253006 title "Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds" @default.
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- W2911253006 doi "https://doi.org/10.1038/s41467-018-08247-x" @default.
- W2911253006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368572" @default.
- W2911253006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30737373" @default.
- W2911253006 hasPublicationYear "2019" @default.
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