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- W2911264664 endingPage "1801868" @default.
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- W2911264664 abstract "Chemotherapy turns tumor cells into tumor vaccines by immunogenic cell death (ICD). However, it remains a challenge to exploit chemotherapy-induced tumor vaccines for solid cancer immunotherapy due to the inefficient effector T cells activation and tumor microenvironment immunosuppression. Here, a matrix metalloprotease 2 responsive liposome (PEG-FA-Lip) composed of cleavable PEG chains covering the folate (FA)-modified liposome is developed to deliver ICD inducer doxorubicin. In breast cancer-bearing mice, PEG-FA-Lip targets both 4T1 breast cancer cells and M2-tumor associated macrophages (M2-TAMs) via FA-receptor mediated endocytosis, resulting in abundant tumor vaccines and efficient elimination of M2-TAMs. The combination of local cytosine-phosphate-guanine (CpG) therapy facilitates PEG-FA-Lip induced tumor vaccines to effectively arouse systematic effector T cells immune response through promoting dendritic cell maturation and immunostimulatory cytokines secretion. The simultaneous elimination of M2-TAMs ensures the activated effector T cells exert antitumor immunity within tumor via decreasing immunosuppressive cytokines secretion and tumor infiltration of Treg cells. After receiving the combined treatment, 30.1% of breast cancer-bearing mice (initial tumor volume > 100 mm3) achieves the goal of tumor eradication. Remarkably, this combination therapy greatly inhibits lung metastasis and controls the growth of already metastasized breast cancers (initial tumor volume > 100 mm3)." @default.
- W2911264664 created "2019-02-21" @default.
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- W2911264664 date "2019-01-30" @default.
- W2911264664 modified "2023-10-16" @default.
- W2911264664 title "Tumors and Their Microenvironment Dual‐Targeting Chemotherapy with Local Immune Adjuvant Therapy for Effective Antitumor Immunity against Breast Cancer" @default.
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- W2911264664 doi "https://doi.org/10.1002/advs.201801868" @default.
- W2911264664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425447" @default.
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- W2911264664 hasPublicationYear "2019" @default.
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