FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911290757> ?p ?o ?g. }

• W2911290757 endingPage "205" @default.
• W2911290757 startingPage "200" @default.
• W2911290757 abstract "Purpose of review Uncontrolled bleeding in trauma secondary to a combination of surgical bleeding and trauma-induced complex coagulopathy is a leading cause of death. Prothrombin complex concentrates (PCCs), recombinant activated factor seven (rFVIIa) and recombinant human prothrombin act as procoagulants by increasing thrombin generation and fibrinogen concentrate aids stable clot formation. This review summarizes the current evidence for procoagulant use in the management of bleeding in trauma, and data and evidence gaps for routine clinical use. Recent findings Retrospective and prospective studies of PCCs (±fibrinogen concentrate) have demonstrated a decreased time to correction of trauma coagulopathy and decreased red cell transfusion with no obvious effect on mortality or thromboembolic outcomes. PCCs in a porcine model of dilutional coagulopathy demonstrated a sustained increase in thrombin generation, unlike recombinant human prothrombin which showed a transient increase and has been studied only in animals. In other retrospective studies, there is a suggestion that lower doses of PCCs may be effective in the setting of acquired coagulopathy. Summary There is increasing evidence that early correction of coagulopathy has survival benefits, and the use of procoagulants as first-line therapy has the potential benefit of rapid access and timely treatment. This requires confirmation in prospective studies." @default.
• W2911290757 created "2019-02-21" @default.
• W2911290757 creator A5045701251 @default.
• W2911290757 creator A5064355731 @default.
• W2911290757 date "2019-04-01" @default.
• W2911290757 modified "2023-10-16" @default.
• W2911290757 title "The use of new procoagulants in blunt and penetrating trauma" @default.
• W2911290757 cites W1225911938 @default.
• W2911290757 cites W1496308634 @default.
• W2911290757 cites W1511722589 @default.
• W2911290757 cites W1572873255 @default.
• W2911290757 cites W1922017495 @default.
• W2911290757 cites W1971358936 @default.
• W2911290757 cites W1974693697 @default.
• W2911290757 cites W1984648226 @default.
• W2911290757 cites W1993994572 @default.
• W2911290757 cites W1994534010 @default.
• W2911290757 cites W1997016178 @default.
• W2911290757 cites W2016360854 @default.
• W2911290757 cites W2028679380 @default.
• W2911290757 cites W2029922639 @default.
• W2911290757 cites W2034607173 @default.
• W2911290757 cites W2042603596 @default.
• W2911290757 cites W2045705472 @default.
• W2911290757 cites W2055292235 @default.
• W2911290757 cites W2055762002 @default.
• W2911290757 cites W2064970256 @default.
• W2911290757 cites W2069798347 @default.
• W2911290757 cites W2088855831 @default.
• W2911290757 cites W2091685079 @default.
• W2911290757 cites W2103139226 @default.
• W2911290757 cites W2114180453 @default.
• W2911290757 cites W2114371027 @default.
• W2911290757 cites W2115233179 @default.
• W2911290757 cites W2127787916 @default.
• W2911290757 cites W2133226878 @default.
• W2911290757 cites W2142624326 @default.
• W2911290757 cites W2165755420 @default.
• W2911290757 cites W2170473047 @default.
• W2911290757 cites W2172509686 @default.
• W2911290757 cites W2338438098 @default.
• W2911290757 cites W2492395381 @default.
• W2911290757 cites W2560679603 @default.
• W2911290757 cites W2575621401 @default.
• W2911290757 cites W2609752450 @default.
• W2911290757 cites W2793502455 @default.
• W2911290757 cites W2793514398 @default.
• W2911290757 cites W2938145938 @default.
• W2911290757 doi "https://doi.org/10.1097/aco.0000000000000696" @default.
• W2911290757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30817396" @default.
• W2911290757 hasPublicationYear "2019" @default.
• W2911290757 type Work @default.
• W2911290757 sameAs 2911290757 @default.
• W2911290757 citedByCount "8" @default.
• W2911290757 countsByYear W29112907572020 @default.
• W2911290757 countsByYear W29112907572021 @default.
• W2911290757 countsByYear W29112907572022 @default.
• W2911290757 countsByYear W29112907572023 @default.
• W2911290757 crossrefType "journal-article" @default.
• W2911290757 hasAuthorship W2911290757A5045701251 @default.
• W2911290757 hasAuthorship W2911290757A5064355731 @default.
• W2911290757 hasConcept C126322002 @default.
• W2911290757 hasConcept C141071460 @default.
• W2911290757 hasConcept C177713679 @default.
• W2911290757 hasConcept C2776301958 @default.
• W2911290757 hasConcept C2777091921 @default.
• W2911290757 hasConcept C2777521253 @default.
• W2911290757 hasConcept C2778734968 @default.
• W2911290757 hasConcept C2779036427 @default.
• W2911290757 hasConcept C2779161974 @default.
• W2911290757 hasConcept C2779936836 @default.
• W2911290757 hasConcept C42219234 @default.
• W2911290757 hasConcept C71924100 @default.
• W2911290757 hasConceptScore W2911290757C126322002 @default.
• W2911290757 hasConceptScore W2911290757C141071460 @default.
• W2911290757 hasConceptScore W2911290757C177713679 @default.
• W2911290757 hasConceptScore W2911290757C2776301958 @default.
• W2911290757 hasConceptScore W2911290757C2777091921 @default.
• W2911290757 hasConceptScore W2911290757C2777521253 @default.
• W2911290757 hasConceptScore W2911290757C2778734968 @default.
• W2911290757 hasConceptScore W2911290757C2779036427 @default.
• W2911290757 hasConceptScore W2911290757C2779161974 @default.
• W2911290757 hasConceptScore W2911290757C2779936836 @default.
• W2911290757 hasConceptScore W2911290757C42219234 @default.
• W2911290757 hasConceptScore W2911290757C71924100 @default.
• W2911290757 hasIssue "2" @default.
• W2911290757 hasLocation W29112907571 @default.
• W2911290757 hasLocation W29112907572 @default.
• W2911290757 hasOpenAccess W2911290757 @default.
• W2911290757 hasPrimaryLocation W29112907571 @default.
• W2911290757 hasRelatedWork W1235031025 @default.
• W2911290757 hasRelatedWork W1572873255 @default.
• W2911290757 hasRelatedWork W2100945436 @default.
• W2911290757 hasRelatedWork W2206874960 @default.
• W2911290757 hasRelatedWork W2465233286 @default.
• W2911290757 hasRelatedWork W2911290757 @default.
• W2911290757 hasRelatedWork W2934953589 @default.
• W2911290757 hasRelatedWork W3156233647 @default.

• next