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- W2911295536 abstract "Every living organism, from bacteria to humans, contains DNA encoding anything from a few hundred genes in intracellular parasites such as Mycoplasma, up to several tens of thousands in many higher organisms. The first observations indicating that the nucleus had some kind of organization were made over a hundred years ago. Understanding of its significance is both limited and aided by the development of techniques, in particular electron microscopy, fluorescence in situ hybridization, DamID and most recently HiC. As our knowledge about genome organization grows, it becomes apparent that the mechanisms are conserved in evolution, even if the individual players may vary. These mechanisms involve DNA binding proteins such as histones, and a number of architectural proteins, some of which are very conserved, with some others having diversified and multiplied, acquiring specific regulatory functions. In this review we will look at the principles of genome organization in a hierarchical manner, from DNA packaging to higher order genome associations such as TADs, and the significance of radial positioning of genomic loci. We will then elaborate on the dynamics of genome organization during development, and how genome architecture plays an important role in cell fate determination. Finally, we will discuss and how misregulation can be a factor in human disease." @default.
- W2911295536 created "2019-02-21" @default.
- W2911295536 creator A5022992391 @default.
- W2911295536 creator A5065708519 @default.
- W2911295536 creator A5078138161 @default.
- W2911295536 date "2019-03-21" @default.
- W2911295536 modified "2023-10-15" @default.
- W2911295536 title "Spatial Genome Organization: From Development to Disease" @default.
- W2911295536 cites W1573323739 @default.
- W2911295536 cites W1599764560 @default.
- W2911295536 cites W1831401007 @default.
- W2911295536 cites W1859117663 @default.
- W2911295536 cites W1875826887 @default.
- W2911295536 cites W1965168140 @default.
- W2911295536 cites W1967187334 @default.
- W2911295536 cites W1968127700 @default.
- W2911295536 cites W1969091651 @default.
- W2911295536 cites W1972132227 @default.
- W2911295536 cites W1972642966 @default.
- W2911295536 cites W1973062929 @default.
- W2911295536 cites W1984340155 @default.
- W2911295536 cites W1986829501 @default.
- W2911295536 cites W1987803647 @default.
- W2911295536 cites W2006639875 @default.
- W2911295536 cites W2009653511 @default.
- W2911295536 cites W2011633097 @default.
- W2911295536 cites W2018855387 @default.
- W2911295536 cites W2022560617 @default.
- W2911295536 cites W2025505154 @default.
- W2911295536 cites W2028630156 @default.
- W2911295536 cites W2030833439 @default.
- W2911295536 cites W2033568291 @default.
- W2911295536 cites W2038254017 @default.
- W2911295536 cites W2038774969 @default.
- W2911295536 cites W2044779040 @default.
- W2911295536 cites W2045362835 @default.
- W2911295536 cites W2048761344 @default.
- W2911295536 cites W2051822822 @default.
- W2911295536 cites W2054160936 @default.
- W2911295536 cites W2060713924 @default.
- W2911295536 cites W2060878862 @default.
- W2911295536 cites W2062009657 @default.
- W2911295536 cites W2065746091 @default.
- W2911295536 cites W2066361594 @default.
- W2911295536 cites W2070021921 @default.
- W2911295536 cites W2073026107 @default.
- W2911295536 cites W2073761355 @default.
- W2911295536 cites W2074350232 @default.
- W2911295536 cites W2076479322 @default.
- W2911295536 cites W2080477348 @default.
- W2911295536 cites W2080615813 @default.
- W2911295536 cites W2083026226 @default.
- W2911295536 cites W2090037139 @default.
- W2911295536 cites W2091642705 @default.
- W2911295536 cites W2097782450 @default.
- W2911295536 cites W2098549100 @default.
- W2911295536 cites W2103609151 @default.
- W2911295536 cites W2106650442 @default.
- W2911295536 cites W2114757437 @default.
- W2911295536 cites W2116302199 @default.
- W2911295536 cites W2116622696 @default.
- W2911295536 cites W2119932131 @default.
- W2911295536 cites W2123299380 @default.
- W2911295536 cites W2124015158 @default.
- W2911295536 cites W2125734502 @default.
- W2911295536 cites W2126466006 @default.
- W2911295536 cites W2127230663 @default.
- W2911295536 cites W2128803395 @default.
- W2911295536 cites W2130732086 @default.
- W2911295536 cites W2133706686 @default.
- W2911295536 cites W2134153749 @default.
- W2911295536 cites W2137202489 @default.
- W2911295536 cites W2143599753 @default.
- W2911295536 cites W2146427646 @default.
- W2911295536 cites W2160908077 @default.
- W2911295536 cites W2162767519 @default.
- W2911295536 cites W2164175250 @default.
- W2911295536 cites W2165974961 @default.
- W2911295536 cites W2166153420 @default.
- W2911295536 cites W2170314963 @default.
- W2911295536 cites W2270152626 @default.
- W2911295536 cites W2324665822 @default.
- W2911295536 cites W2332009504 @default.
- W2911295536 cites W2411027615 @default.
- W2911295536 cites W2577253766 @default.
- W2911295536 cites W2581101120 @default.
- W2911295536 cites W2587651673 @default.
- W2911295536 cites W2599773520 @default.
- W2911295536 cites W2603000633 @default.
- W2911295536 cites W2607008467 @default.
- W2911295536 cites W2610160407 @default.
- W2911295536 cites W2614144400 @default.
- W2911295536 cites W2616198309 @default.
- W2911295536 cites W2734870846 @default.
- W2911295536 cites W2739985642 @default.
- W2911295536 cites W2747643030 @default.
- W2911295536 cites W2747899047 @default.
- W2911295536 cites W2761461280 @default.
- W2911295536 cites W2765547660 @default.
- W2911295536 cites W2765567136 @default.