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- W2911295867 abstract "At around 150 000 neurons, the adult Drosophila melanogaster central nervous system is one of the largest species, for which a complete cellular catalogue is imminent. While numerically much simpler than mammalian brains, its complexity is still difficult to parse without grouping neurons into consistent types, which can number 1-1000 cells per hemisphere. We review how neuroanatomical and gene expression data are being used to discover neuronal types at scale. The correlation among multiple co-varying neuronal properties, including lineage, gene expression, morphology, connectivity, response properties and shared behavioral significance is essential to the definition of neuronal cell type. Initial studies comparing morphological and transcriptomic definitions of neuronal type suggest that these are highly consistent, but there is much to do to match these approaches brain-wide. Matched single-cell transcriptomic and morphological data provide an effective reference point to integrate other data types, including connectomics data. This will significantly enhance our ability to make functional predictions from brain wiring diagrams as well facilitating molecular genetic manipulation of neuronal types." @default.
- W2911295867 created "2019-02-21" @default.
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- W2911295867 creator A5072640739 @default.
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- W2911295867 date "2019-06-01" @default.
- W2911295867 modified "2023-10-06" @default.
- W2911295867 title "Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics" @default.
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- W2911295867 doi "https://doi.org/10.1016/j.conb.2018.12.012" @default.
- W2911295867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30703584" @default.
- W2911295867 hasPublicationYear "2019" @default.
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