FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911300598> ?p ?o ?g. }

• W2911300598 abstract "Opa interacting protein 5 (OIP5) overexpression is associated with human carcinoma. However, its biological function, underlying mechanism and clinical significance in liver cancer remain unknown. In the present study, the effects of OIP5 expression on liver cancer, and the mechanisms regulating these effects, were investigated. OIP5 expression was measured in human hepatocellular carcinoma (HCC) tissues and liver cancer cell lines. The effect of OIP5 knockdown on tumorigenesis was also detected in nude mice, and differentially‑expressed genes (DEGs) were identified and their biological functions were identified. The results indicated that OIP5 expression was significantly upregulated in HCC tissues and four liver cancer cell lines (P<0.01). Increased OIP5 protein expression significantly predicted reduced survival rate of patients with HCC (P<0.01). OIP5 knockdown resulted in the suppression of proliferation and colony forming abilities, cell cycle arrest at the G0/G1 or G2/M phases, and promotion of cell apoptosis. A total of 628 DEGs, including 87 upregulated and 541 downregulated genes, were identified following OIP5 knockdown. Functional enrichment analysis indicated that DEGs were involved in 'RNA Post‑Transcriptional Modification, Cancer and Organismal Injury and Abnormalities'. Finally, OIP5 knockdown in Huh7 cells dysregulated bone morphogenetic protein receptor type 2/JUN/checkpoint kinase 1/Rac family small GTPase 1 expression. In conclusion, the overall results demonstrated the involvement of OIP5 in the progression of liver cancer and its mechanism of action." @default.
• W2911300598 created "2019-02-21" @default.
• W2911300598 creator A5010145000 @default.
• W2911300598 creator A5010233977 @default.
• W2911300598 creator A5011547653 @default.
• W2911300598 creator A5030750597 @default.
• W2911300598 creator A5049582588 @default.
• W2911300598 creator A5053284741 @default.
• W2911300598 creator A5076256227 @default.
• W2911300598 creator A5077542931 @default.
• W2911300598 date "2019-02-11" @default.
• W2911300598 modified "2023-09-29" @default.
• W2911300598 title "Overexpression of Opa interacting protein�5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation" @default.
• W2911300598 cites W1813394859 @default.
• W2911300598 cites W1958172470 @default.
• W2911300598 cites W1964829819 @default.
• W2911300598 cites W1982405803 @default.
• W2911300598 cites W1985213644 @default.
• W2911300598 cites W1994552664 @default.
• W2911300598 cites W2012843157 @default.
• W2911300598 cites W2018289835 @default.
• W2911300598 cites W2029819398 @default.
• W2911300598 cites W2034728948 @default.
• W2911300598 cites W2037174767 @default.
• W2911300598 cites W2040904248 @default.
• W2911300598 cites W2056183881 @default.
• W2911300598 cites W2064709411 @default.
• W2911300598 cites W2067119153 @default.
• W2911300598 cites W2081626500 @default.
• W2911300598 cites W2086141103 @default.
• W2911300598 cites W2090365198 @default.
• W2911300598 cites W2100837269 @default.
• W2911300598 cites W2106913297 @default.
• W2911300598 cites W2108244474 @default.
• W2911300598 cites W2129122766 @default.
• W2911300598 cites W2165263439 @default.
• W2911300598 cites W2357440167 @default.
• W2911300598 cites W2421953095 @default.
• W2911300598 cites W2463600666 @default.
• W2911300598 cites W2557612133 @default.
• W2911300598 cites W2570618306 @default.
• W2911300598 cites W2582878252 @default.
• W2911300598 cites W2586101183 @default.
• W2911300598 cites W2587057147 @default.
• W2911300598 cites W2595819742 @default.
• W2911300598 cites W2597872842 @default.
• W2911300598 cites W2737785069 @default.
• W2911300598 cites W2738637586 @default.
• W2911300598 cites W2741842068 @default.
• W2911300598 cites W2742045129 @default.
• W2911300598 cites W2766624177 @default.
• W2911300598 cites W2767035962 @default.
• W2911300598 cites W2767155997 @default.
• W2911300598 cites W2774985486 @default.
• W2911300598 cites W2889646458 @default.
• W2911300598 doi "https://doi.org/10.3892/or.2019.7006" @default.
• W2911300598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6412147" @default.
• W2911300598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30816485" @default.
• W2911300598 hasPublicationYear "2019" @default.
• W2911300598 type Work @default.
• W2911300598 sameAs 2911300598 @default.
• W2911300598 citedByCount "9" @default.
• W2911300598 countsByYear W29113005982021 @default.
• W2911300598 countsByYear W29113005982022 @default.
• W2911300598 countsByYear W29113005982023 @default.
• W2911300598 crossrefType "journal-article" @default.
• W2911300598 hasAuthorship W2911300598A5010145000 @default.
• W2911300598 hasAuthorship W2911300598A5010233977 @default.
• W2911300598 hasAuthorship W2911300598A5011547653 @default.
• W2911300598 hasAuthorship W2911300598A5030750597 @default.
• W2911300598 hasAuthorship W2911300598A5049582588 @default.
• W2911300598 hasAuthorship W2911300598A5053284741 @default.
• W2911300598 hasAuthorship W2911300598A5076256227 @default.
• W2911300598 hasAuthorship W2911300598A5077542931 @default.
• W2911300598 hasBestOaLocation W29113005981 @default.
• W2911300598 hasConcept C104317684 @default.
• W2911300598 hasConcept C105696609 @default.
• W2911300598 hasConcept C121608353 @default.
• W2911300598 hasConcept C127561419 @default.
• W2911300598 hasConcept C173396325 @default.
• W2911300598 hasConcept C190283241 @default.
• W2911300598 hasConcept C2776231280 @default.
• W2911300598 hasConcept C2778019345 @default.
• W2911300598 hasConcept C2781018059 @default.
• W2911300598 hasConcept C29537977 @default.
• W2911300598 hasConcept C502942594 @default.
• W2911300598 hasConcept C54355233 @default.
• W2911300598 hasConcept C55493867 @default.
• W2911300598 hasConcept C555283112 @default.
• W2911300598 hasConcept C62112901 @default.
• W2911300598 hasConcept C86803240 @default.
• W2911300598 hasConceptScore W2911300598C104317684 @default.
• W2911300598 hasConceptScore W2911300598C105696609 @default.
• W2911300598 hasConceptScore W2911300598C121608353 @default.
• W2911300598 hasConceptScore W2911300598C127561419 @default.
• W2911300598 hasConceptScore W2911300598C173396325 @default.
• W2911300598 hasConceptScore W2911300598C190283241 @default.
• W2911300598 hasConceptScore W2911300598C2776231280 @default.
• W2911300598 hasConceptScore W2911300598C2778019345 @default.
• W2911300598 hasConceptScore W2911300598C2781018059 @default.

• next