FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911301679> ?p ?o ?g. }

• W2911301679 abstract "Gaseous oxygen is essential for all aerobic animals, without which mitochondrial respiration and oxidative phosphorylation cannot take place. It is not, however, regarded as a ‘nutrient’ by nutritionists and does not feature as such within the discipline of nutritional science. This is primarily a consequence of the route by which O2 enters the body, which is via the nose and lungs in terrestrial animals as opposed to the mouth and gastrointestinal tract for what are customarily considered as nutrients. It is argued that the route of entry should not be the critical factor in defining whether a substance is, or is not, a nutrient. Indeed, O2 unambiguously meets the standard dictionary definitions of a nutrient, such as ‘a substance that provides nourishment for the maintenance of life and for growth’ (Oxford English Dictionary). O2 is generally available in abundance, but deficiency occurs at high altitude and during deep sea dives, as well as in lung diseases. These impact on the provision at a whole-body level, but a low pO2 is characteristic of specific tissues includings the retina and brain, while deficiency, or overt hypoxia, is evident in certain conditions such as ischaemic disease and in tumours - and in white adipose tissue in obesity. Hypoxia results in a switch from oxidative metabolism to increased glucose utilisation through anaerobic glycolysis, and there are extensive changes in the expression of multiple genes in O2-deficient cells. These changes are driven by hypoxia-sensitive transcription factors, particularly hypoxia-inducible factor-1 (HIF-1). O2 deficiency at a whole-body level can be treated by therapy or supplementation, but O2 is also toxic through the generation of reactive oxygen species. It is concluded that O2 is a critical, but overlooked, nutrient which should be considered as part of the landscape of nutritional science." @default.
• W2911301679 created "2019-02-21" @default.
• W2911301679 creator A5023985566 @default.
• W2911301679 date "2019-02-12" @default.
• W2911301679 modified "2023-10-11" @default.
• W2911301679 title "Oxygen—A Critical, but Overlooked, Nutrient" @default.
• W2911301679 cites W1482076735 @default.
• W2911301679 cites W1524321743 @default.
• W2911301679 cites W1562891630 @default.
• W2911301679 cites W1563801633 @default.
• W2911301679 cites W1563823441 @default.
• W2911301679 cites W1587875569 @default.
• W2911301679 cites W1799768544 @default.
• W2911301679 cites W1842875237 @default.
• W2911301679 cites W1927710737 @default.
• W2911301679 cites W1966483924 @default.
• W2911301679 cites W1971226856 @default.
• W2911301679 cites W1972235985 @default.
• W2911301679 cites W1980270634 @default.
• W2911301679 cites W1983199304 @default.
• W2911301679 cites W1983213493 @default.
• W2911301679 cites W1985048387 @default.
• W2911301679 cites W1985497859 @default.
• W2911301679 cites W1990004173 @default.
• W2911301679 cites W1993959456 @default.
• W2911301679 cites W1996713062 @default.
• W2911301679 cites W2000272522 @default.
• W2911301679 cites W2002041700 @default.
• W2911301679 cites W2004087478 @default.
• W2911301679 cites W2008869160 @default.
• W2911301679 cites W2008946188 @default.
• W2911301679 cites W2011810742 @default.
• W2911301679 cites W2015873509 @default.
• W2911301679 cites W2022081142 @default.
• W2911301679 cites W2030351692 @default.
• W2911301679 cites W2037774298 @default.
• W2911301679 cites W2042624112 @default.
• W2911301679 cites W2045632404 @default.
• W2911301679 cites W2050775539 @default.
• W2911301679 cites W2055437178 @default.
• W2911301679 cites W2058610977 @default.
• W2911301679 cites W2059511498 @default.
• W2911301679 cites W2072829138 @default.
• W2911301679 cites W2076633494 @default.
• W2911301679 cites W2077156460 @default.
• W2911301679 cites W2086879937 @default.
• W2911301679 cites W2091725413 @default.
• W2911301679 cites W2094352498 @default.
• W2911301679 cites W2094741548 @default.
• W2911301679 cites W2099284750 @default.
• W2911301679 cites W2102761049 @default.
• W2911301679 cites W2107339809 @default.
• W2911301679 cites W2114412752 @default.
• W2911301679 cites W2127642118 @default.
• W2911301679 cites W2129118102 @default.
• W2911301679 cites W2130764919 @default.
• W2911301679 cites W2132358997 @default.
• W2911301679 cites W2132968158 @default.
• W2911301679 cites W2134467433 @default.
• W2911301679 cites W2136024338 @default.
• W2911301679 cites W2138750223 @default.
• W2911301679 cites W2142493194 @default.
• W2911301679 cites W2143137499 @default.
• W2911301679 cites W2145053595 @default.
• W2911301679 cites W2146877487 @default.
• W2911301679 cites W2148700237 @default.
• W2911301679 cites W2150350398 @default.
• W2911301679 cites W2151398015 @default.
• W2911301679 cites W2160915024 @default.
• W2911301679 cites W2165472748 @default.
• W2911301679 cites W2172249877 @default.
• W2911301679 cites W2181584393 @default.
• W2911301679 cites W2207236357 @default.
• W2911301679 cites W2226336971 @default.
• W2911301679 cites W2274830107 @default.
• W2911301679 cites W2304389785 @default.
• W2911301679 cites W2311493064 @default.
• W2911301679 cites W2344898236 @default.
• W2911301679 cites W2472010266 @default.
• W2911301679 cites W2521282167 @default.
• W2911301679 cites W2587489851 @default.
• W2911301679 cites W2605774827 @default.
• W2911301679 cites W2606455791 @default.
• W2911301679 cites W2620406790 @default.
• W2911301679 cites W2751857620 @default.
• W2911301679 cites W4239891932 @default.
• W2911301679 cites W4251031755 @default.
• W2911301679 doi "https://doi.org/10.3389/fnut.2019.00010" @default.
• W2911301679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6379287" @default.
• W2911301679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30809528" @default.
• W2911301679 hasPublicationYear "2019" @default.
• W2911301679 type Work @default.
• W2911301679 sameAs 2911301679 @default.
• W2911301679 citedByCount "23" @default.
• W2911301679 countsByYear W29113016792020 @default.
• W2911301679 countsByYear W29113016792021 @default.
• W2911301679 countsByYear W29113016792022 @default.
• W2911301679 countsByYear W29113016792023 @default.
• W2911301679 crossrefType "journal-article" @default.
• W2911301679 hasAuthorship W2911301679A5023985566 @default.

• next