FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911308132> ?p ?o ?g. }

• W2911308132 endingPage "574" @default.
• W2911308132 startingPage "574" @default.
• W2911308132 abstract "Graphene is capable of promoting osteogenesis without chemical induction. Nevertheless, the underlying mechanism(s) remain largely unknown. The objectives here were: (i) to assess whether graphene scaffolds are capable of supporting osteogenesis in vivo and; (ii) to ascertain the participation of the integrin/FAK mechanotransduction axis during the osteogenic differentiation induced by graphene. MSC-impregnated graphene scaffolds (n = 6) were implanted into immunocompromised mice (28 days). Alternatively, MSCs were seeded onto PDMS substrates (modulus of elasticity = 130, 830 and 1300 kPa) coated with a single monomolecular layer of graphene and cultured in basal medium (10 days). The ensuing expressions of FAK-p397, integrin, ROCK1, F-actin, Smad p1/5, RUNX2, OCN and OPN were evaluated by Western blot (n = 3). As controls, MSCs were plated onto uncoated PDMS in the presence of mechanotransduction inhibitors (echistatin, Y27632 and DMH1). MSC-impregnated graphene scaffolds exhibited positive immunoexpression of bone-related markers (RUNX2 and OPN) without the assistance of osteogenic inducers. In vitro, regardless of the stiffness of the underlying PDMS substrate, MSCs seeded onto graphene-coated PDMS substrates demonstrated higher expressions of all tested osteogenic and integrin/FAK proteins tested compared to MSCs seeded onto PDMS alone. Hence, graphene promotes osteogenesis via the activation of the mechanosensitive integrin/FAK axis." @default.
• W2911308132 created "2019-02-21" @default.
• W2911308132 creator A5025331178 @default.
• W2911308132 creator A5055314759 @default.
• W2911308132 creator A5069706353 @default.
• W2911308132 creator A5071881588 @default.
• W2911308132 date "2019-01-29" @default.
• W2911308132 modified "2023-10-14" @default.
• W2911308132 title "Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis" @default.
• W2911308132 cites W1519092455 @default.
• W2911308132 cites W1578896203 @default.
• W2911308132 cites W1964935932 @default.
• W2911308132 cites W1972507748 @default.
• W2911308132 cites W1975666052 @default.
• W2911308132 cites W1977489066 @default.
• W2911308132 cites W1977831478 @default.
• W2911308132 cites W1979860021 @default.
• W2911308132 cites W1984740575 @default.
• W2911308132 cites W1986767024 @default.
• W2911308132 cites W1987367101 @default.
• W2911308132 cites W1994423139 @default.
• W2911308132 cites W2014935324 @default.
• W2911308132 cites W2015496410 @default.
• W2911308132 cites W2026067386 @default.
• W2911308132 cites W2029959239 @default.
• W2911308132 cites W2029991360 @default.
• W2911308132 cites W2037843283 @default.
• W2911308132 cites W2050888989 @default.
• W2911308132 cites W2059105779 @default.
• W2911308132 cites W2060613028 @default.
• W2911308132 cites W2074645659 @default.
• W2911308132 cites W2074801305 @default.
• W2911308132 cites W2077405929 @default.
• W2911308132 cites W2088215231 @default.
• W2911308132 cites W2092233035 @default.
• W2911308132 cites W2093987462 @default.
• W2911308132 cites W2099052265 @default.
• W2911308132 cites W2114270638 @default.
• W2911308132 cites W2122172801 @default.
• W2911308132 cites W2134208433 @default.
• W2911308132 cites W2151343832 @default.
• W2911308132 cites W2166593341 @default.
• W2911308132 cites W2167973594 @default.
• W2911308132 cites W2419435773 @default.
• W2911308132 cites W2465704893 @default.
• W2911308132 cites W2527304415 @default.
• W2911308132 cites W2586399067 @default.
• W2911308132 cites W2612241214 @default.
• W2911308132 cites W265598652 @default.
• W2911308132 cites W2791579163 @default.
• W2911308132 doi "https://doi.org/10.3390/ijms20030574" @default.
• W2911308132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6387117" @default.
• W2911308132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30699966" @default.
• W2911308132 hasPublicationYear "2019" @default.
• W2911308132 type Work @default.
• W2911308132 sameAs 2911308132 @default.
• W2911308132 citedByCount "44" @default.
• W2911308132 countsByYear W29113081322019 @default.
• W2911308132 countsByYear W29113081322020 @default.
• W2911308132 countsByYear W29113081322021 @default.
• W2911308132 countsByYear W29113081322022 @default.
• W2911308132 countsByYear W29113081322023 @default.
• W2911308132 crossrefType "journal-article" @default.
• W2911308132 hasAuthorship W2911308132A5025331178 @default.
• W2911308132 hasAuthorship W2911308132A5055314759 @default.
• W2911308132 hasAuthorship W2911308132A5069706353 @default.
• W2911308132 hasAuthorship W2911308132A5071881588 @default.
• W2911308132 hasBestOaLocation W29113081321 @default.
• W2911308132 hasConcept C12554922 @default.
• W2911308132 hasConcept C1491633281 @default.
• W2911308132 hasConcept C151166631 @default.
• W2911308132 hasConcept C170493617 @default.
• W2911308132 hasConcept C171250308 @default.
• W2911308132 hasConcept C181104049 @default.
• W2911308132 hasConcept C185592680 @default.
• W2911308132 hasConcept C192562407 @default.
• W2911308132 hasConcept C195687474 @default.
• W2911308132 hasConcept C198826908 @default.
• W2911308132 hasConcept C202751555 @default.
• W2911308132 hasConcept C203014093 @default.
• W2911308132 hasConcept C2776363554 @default.
• W2911308132 hasConcept C2778260815 @default.
• W2911308132 hasConcept C2780804394 @default.
• W2911308132 hasConcept C30080830 @default.
• W2911308132 hasConcept C4001165 @default.
• W2911308132 hasConcept C50254741 @default.
• W2911308132 hasConcept C55493867 @default.
• W2911308132 hasConcept C62478195 @default.
• W2911308132 hasConcept C86803240 @default.
• W2911308132 hasConcept C95444343 @default.
• W2911308132 hasConceptScore W2911308132C12554922 @default.
• W2911308132 hasConceptScore W2911308132C1491633281 @default.
• W2911308132 hasConceptScore W2911308132C151166631 @default.
• W2911308132 hasConceptScore W2911308132C170493617 @default.
• W2911308132 hasConceptScore W2911308132C171250308 @default.
• W2911308132 hasConceptScore W2911308132C181104049 @default.
• W2911308132 hasConceptScore W2911308132C185592680 @default.
• W2911308132 hasConceptScore W2911308132C192562407 @default.

• next