FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911317435> ?p ?o ?g. }

• W2911317435 endingPage "135" @default.
• W2911317435 startingPage "127" @default.
• W2911317435 abstract "Molecular interactions between drug and polymeric carriers are believed to be the key for high drug loading and better physical stability of micro-particles. However, molecular interactions between drug and polymer are still difficult to investigate using only experimental tools. In this study, high-loaded glipizide (GLP)/hydroxypropyl methylcellulose acetate succinate (HPMCAS) (1/1 w/w) micro-particles were prepared using an in situ pH-dependent solubility method. Molecular interactions within the micro-particles were investigated by integrated experimental and modeling techniques. The dissolution rate of GLP/HPMCAS micro-particles was significantly better than those of solid dispersions and physical mixtures. Scanning electron microscopy images showed that the polymer inhibited GLP recrystallization. Experimental (FTIR spectroscopy, differential scanning calorimetry, powder X-ray diffraction and nuclear magnetic resonance spectroscopy) and molecular dynamics simulation revealed that hydrogen-bonding was the key to the properties of the micro-particles. Our research developed high drug-loading GLP/HPMCAS micro-particles and investigated the interactions between drug and polymer at the molecular level. This integrated approach could be practical methodology for future formulation design." @default.
• W2911317435 created "2019-02-21" @default.
• W2911317435 creator A5024615233 @default.
• W2911317435 creator A5052749080 @default.
• W2911317435 creator A5069771802 @default.
• W2911317435 creator A5078536988 @default.
• W2911317435 creator A5080298585 @default.
• W2911317435 creator A5080374676 @default.
• W2911317435 creator A5081287332 @default.
• W2911317435 creator A5086581794 @default.
• W2911317435 date "2019-04-01" @default.
• W2911317435 modified "2023-10-05" @default.
• W2911317435 title "Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques" @default.
• W2911317435 cites W1974033331 @default.
• W2911317435 cites W1976021540 @default.
• W2911317435 cites W1978793971 @default.
• W2911317435 cites W2001533174 @default.
• W2911317435 cites W2009569320 @default.
• W2911317435 cites W2023677520 @default.
• W2911317435 cites W2027369785 @default.
• W2911317435 cites W2049556095 @default.
• W2911317435 cites W2079667312 @default.
• W2911317435 cites W2106241844 @default.
• W2911317435 cites W2133061394 @default.
• W2911317435 cites W2156829937 @default.
• W2911317435 cites W2157470145 @default.
• W2911317435 cites W2261208107 @default.
• W2911317435 cites W2269869829 @default.
• W2911317435 cites W2284656901 @default.
• W2911317435 cites W2313569107 @default.
• W2911317435 cites W2321603802 @default.
• W2911317435 cites W2411231621 @default.
• W2911317435 cites W2430387656 @default.
• W2911317435 cites W2467014326 @default.
• W2911317435 cites W2471778072 @default.
• W2911317435 cites W2513925745 @default.
• W2911317435 cites W2523300513 @default.
• W2911317435 cites W2563834067 @default.
• W2911317435 cites W2583179415 @default.
• W2911317435 cites W2604337791 @default.
• W2911317435 cites W2606755086 @default.
• W2911317435 cites W2619763996 @default.
• W2911317435 cites W2620921398 @default.
• W2911317435 cites W2775991828 @default.
• W2911317435 cites W2784170998 @default.
• W2911317435 cites W2784207185 @default.
• W2911317435 cites W2791119271 @default.
• W2911317435 cites W2793680171 @default.
• W2911317435 cites W4210982805 @default.
• W2911317435 cites W4249310158 @default.
• W2911317435 doi "https://doi.org/10.1016/j.ejps.2019.02.005" @default.
• W2911317435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30735823" @default.
• W2911317435 hasPublicationYear "2019" @default.
• W2911317435 type Work @default.
• W2911317435 sameAs 2911317435 @default.
• W2911317435 citedByCount "12" @default.
• W2911317435 countsByYear W29113174352020 @default.
• W2911317435 countsByYear W29113174352021 @default.
• W2911317435 countsByYear W29113174352022 @default.
• W2911317435 countsByYear W29113174352023 @default.
• W2911317435 crossrefType "journal-article" @default.
• W2911317435 hasAuthorship W2911317435A5024615233 @default.
• W2911317435 hasAuthorship W2911317435A5052749080 @default.
• W2911317435 hasAuthorship W2911317435A5069771802 @default.
• W2911317435 hasAuthorship W2911317435A5078536988 @default.
• W2911317435 hasAuthorship W2911317435A5080298585 @default.
• W2911317435 hasAuthorship W2911317435A5080374676 @default.
• W2911317435 hasAuthorship W2911317435A5081287332 @default.
• W2911317435 hasAuthorship W2911317435A5086581794 @default.
• W2911317435 hasConcept C121332964 @default.
• W2911317435 hasConcept C127413603 @default.
• W2911317435 hasConcept C134018914 @default.
• W2911317435 hasConcept C155574463 @default.
• W2911317435 hasConcept C159985019 @default.
• W2911317435 hasConcept C171250308 @default.
• W2911317435 hasConcept C178790620 @default.
• W2911317435 hasConcept C185592680 @default.
• W2911317435 hasConcept C192562407 @default.
• W2911317435 hasConcept C26771246 @default.
• W2911317435 hasConcept C2779555806 @default.
• W2911317435 hasConcept C2779820397 @default.
• W2911317435 hasConcept C39519442 @default.
• W2911317435 hasConcept C42360764 @default.
• W2911317435 hasConcept C521977710 @default.
• W2911317435 hasConcept C555293320 @default.
• W2911317435 hasConcept C71924100 @default.
• W2911317435 hasConcept C88380143 @default.
• W2911317435 hasConcept C97355855 @default.
• W2911317435 hasConceptScore W2911317435C121332964 @default.
• W2911317435 hasConceptScore W2911317435C127413603 @default.
• W2911317435 hasConceptScore W2911317435C134018914 @default.
• W2911317435 hasConceptScore W2911317435C155574463 @default.
• W2911317435 hasConceptScore W2911317435C159985019 @default.
• W2911317435 hasConceptScore W2911317435C171250308 @default.
• W2911317435 hasConceptScore W2911317435C178790620 @default.
• W2911317435 hasConceptScore W2911317435C185592680 @default.
• W2911317435 hasConceptScore W2911317435C192562407 @default.
• W2911317435 hasConceptScore W2911317435C26771246 @default.

• next