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- W2911357002 abstract "Hybrid (both intra-species and inter-species) cell lines arise through intentional or nonintentional fusion of somatic cells having different origins. Hybrid cell lines can pose a problem for authentication testing to confirm cell line identity, since the results obtained may not conform to the results expected for the two parental cell types. Thus, depending on the identity testing methodology, a hybrid cell may display characteristics of one of the parental cell type or of both. In some instances, the hybrid cell line may display characteristics that are different from those displayed by either parental cell type; these differences may not necessarily indicate cellular cross-contamination. Testing should be performed as soon as possible after an intended fusion has occurred, so that a baseline reference profile is available for later comparison. In this article, we describe the various approaches that have been used for identifying hybrid cell lines and the results that might be expected when using various technologies for this purpose." @default.
- W2911357002 created "2019-02-21" @default.
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- W2911357002 date "2019-01-23" @default.
- W2911357002 modified "2023-10-17" @default.
- W2911357002 title "Authenticating Hybrid Cell Lines" @default.
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- W2911357002 doi "https://doi.org/10.5772/intechopen.80669" @default.
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