Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911380188> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2911380188 endingPage "119" @default.
- W2911380188 startingPage "111" @default.
- W2911380188 abstract "Background: In the present study, we aimed to investigate the expression and prognostic value of co-stimulatory molecules, programmed death ligand-1 (PD-L1) and PD-L2, in ovarian cancer (OC). Methods: Immunohistochemical (IHC) staining was used to assess the expressions of PD-L1 and PD-L2 in 77 cases of OC, and 10 cases of benign ovarian cyst were employed as negative controls. Moreover, χ 2 test was used to analyze the correlation between the PD-L1/PD-L2 expression and clinicopathological parameters. Kaplan-Meier method was used to compare the effects of PD-L1/PD-L2 expression level on the overall survival (OS) of OC patients. Results: PD-L1 and PD-L2 were mainly expressed on membrane and in cytoplasm of OC cells. The high-expression rate of PD-L1 and PD-L2 in OC tissues was 44.16% (34/77) and 22.08% (17/77), respectively. The expression of PD-L1 in OC cells was significantly correlated with FIGO stage (P=0.026), while its expression was not significantly correlated with other clinicopathological parameters. There was no significant correlation between PD-L2 and any clinicopathological parameters. Kaplan-Meier survival analysis showed that the OS of high PD-L1 expression group was significantly shorter compared with the low PD-L1 expression group (HR =2.689, 95% CI: 1.400–5.163). Patients with high PD-L2 expression also exhibited significantly shorter OS (HR =2.204, 95% CI: 1.037–4.682). Multivariable analysis displayed that high expression of PD-L1 (HR =2.275, 95% CI: 1.120–4.169), high expression of PD-L2 (HR =2.314, 95% CI: 1.136–4.714) and FIGO stage (HR =11.229, 95% CI: 1.373–91.865) were independent prognostic factors of OC. When negative expressions of both PD-L1 and PD-L2 were used as a combined prognostic factor, the OS was significantly prolonged (HR =3.396, 95% CI: 1.858–6.029). According to our previous studies, patients with negative PD-L1 expression and high T-bet + TIL infiltration have higher OS than other patients. Patients with positive PD-L1 expression and low T-bet + TIL infiltration exhibit the shortest OS. Collectively, our findings provided the basis for PD-1/PD-L1 or PD-1/PD-L2 blockade therapy for OC patients. Conclusions: Co-stimulatory molecules, PD-L1 and PD-L2, were highly expressed in OC tissues, and their expression levels were correlated with FIGO stage, age and prognosis. These results suggested that PD-L1 and PD-L2 were involved in the occurrence and development of malignant OC, indicating their potential value in clinical diagnosis and prognosis of OC." @default.
- W2911380188 created "2019-02-21" @default.
- W2911380188 creator A5006800281 @default.
- W2911380188 creator A5010607078 @default.
- W2911380188 creator A5015499602 @default.
- W2911380188 creator A5023546935 @default.
- W2911380188 creator A5035121335 @default.
- W2911380188 creator A5043103663 @default.
- W2911380188 creator A5077469510 @default.
- W2911380188 date "2019-01-24" @default.
- W2911380188 modified "2023-09-25" @default.
- W2911380188 title "Expression and prognostic value of PD-L1 and PD-L2 in ovarian cancer" @default.
- W2911380188 doi "https://doi.org/10.21037/26716" @default.
- W2911380188 hasPublicationYear "2019" @default.
- W2911380188 type Work @default.
- W2911380188 sameAs 2911380188 @default.
- W2911380188 citedByCount "0" @default.
- W2911380188 crossrefType "journal-article" @default.
- W2911380188 hasAuthorship W2911380188A5006800281 @default.
- W2911380188 hasAuthorship W2911380188A5010607078 @default.
- W2911380188 hasAuthorship W2911380188A5015499602 @default.
- W2911380188 hasAuthorship W2911380188A5023546935 @default.
- W2911380188 hasAuthorship W2911380188A5035121335 @default.
- W2911380188 hasAuthorship W2911380188A5043103663 @default.
- W2911380188 hasAuthorship W2911380188A5077469510 @default.
- W2911380188 hasConcept C121608353 @default.
- W2911380188 hasConcept C126322002 @default.
- W2911380188 hasConcept C142724271 @default.
- W2911380188 hasConcept C143998085 @default.
- W2911380188 hasConcept C146357865 @default.
- W2911380188 hasConcept C151730666 @default.
- W2911380188 hasConcept C204232928 @default.
- W2911380188 hasConcept C2777701055 @default.
- W2911380188 hasConcept C2780427987 @default.
- W2911380188 hasConcept C2781053074 @default.
- W2911380188 hasConcept C71924100 @default.
- W2911380188 hasConcept C86803240 @default.
- W2911380188 hasConcept C90924648 @default.
- W2911380188 hasConceptScore W2911380188C121608353 @default.
- W2911380188 hasConceptScore W2911380188C126322002 @default.
- W2911380188 hasConceptScore W2911380188C142724271 @default.
- W2911380188 hasConceptScore W2911380188C143998085 @default.
- W2911380188 hasConceptScore W2911380188C146357865 @default.
- W2911380188 hasConceptScore W2911380188C151730666 @default.
- W2911380188 hasConceptScore W2911380188C204232928 @default.
- W2911380188 hasConceptScore W2911380188C2777701055 @default.
- W2911380188 hasConceptScore W2911380188C2780427987 @default.
- W2911380188 hasConceptScore W2911380188C2781053074 @default.
- W2911380188 hasConceptScore W2911380188C71924100 @default.
- W2911380188 hasConceptScore W2911380188C86803240 @default.
- W2911380188 hasConceptScore W2911380188C90924648 @default.
- W2911380188 hasIssue "1" @default.
- W2911380188 hasLocation W29113801881 @default.
- W2911380188 hasOpenAccess W2911380188 @default.
- W2911380188 hasPrimaryLocation W29113801881 @default.
- W2911380188 hasRelatedWork W2365348826 @default.
- W2911380188 hasRelatedWork W2390831976 @default.
- W2911380188 hasRelatedWork W2430551214 @default.
- W2911380188 hasRelatedWork W2749849377 @default.
- W2911380188 hasRelatedWork W2888133608 @default.
- W2911380188 hasRelatedWork W2898536268 @default.
- W2911380188 hasRelatedWork W2911675656 @default.
- W2911380188 hasRelatedWork W2932480032 @default.
- W2911380188 hasRelatedWork W2940215311 @default.
- W2911380188 hasRelatedWork W2954053017 @default.
- W2911380188 hasRelatedWork W3001376261 @default.
- W2911380188 hasRelatedWork W3004623149 @default.
- W2911380188 hasRelatedWork W3010146650 @default.
- W2911380188 hasRelatedWork W3021023953 @default.
- W2911380188 hasRelatedWork W3029667931 @default.
- W2911380188 hasRelatedWork W3037407687 @default.
- W2911380188 hasRelatedWork W3047567711 @default.
- W2911380188 hasRelatedWork W3105436135 @default.
- W2911380188 hasRelatedWork W3147093913 @default.
- W2911380188 hasRelatedWork W3188961578 @default.
- W2911380188 hasVolume "8" @default.
- W2911380188 isParatext "false" @default.
- W2911380188 isRetracted "false" @default.
- W2911380188 magId "2911380188" @default.
- W2911380188 workType "article" @default.