Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911383577> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W2911383577 endingPage "1" @default.
- W2911383577 startingPage "1" @default.
- W2911383577 abstract "Background: Medicinal plants have been the source of innumerable drugs. Opioids derived from plants are commonly used analgesics. However, they are associated with side effects ranging from vomiting, constipation to tolerance, and dependence. Hence, the search for safe and efficacious analgesic is on-going. Aims and Objectives: The aim of the study was to assess the analgesic potential of the ethanolic extract of L. siceraria roots (EELSR) in albino mice by radiant heat method and to compare it with pentazocine. Materials and Methods: Albino mice were divided into four groups randomly. Group 1 was given saline (0.1 mg/kg) orally (control). Group 2 was injected pentazocine 4 mg/kg (standard) intraperitoneally. Groups 3 and 4 were test groups and were administered EELSR 100 mg/kg BW and 200 mg/kg BW orally, respectively. Radiant heat method was used to screen for analgesic potential. Results: Our study demonstrated the steady increase in reaction time in the test groups which received EELSR at both the doses. Maximum analgesic activity was observed at 60 min. EELSR has good analgesic activity in comparison with control. However, pentazocine has significantly better activity than EELSR at both the doses. EELSR at 200 mg/kg BW has comparable analgesic activity to pentazocine only at 15 min. Conclusion: The EELSR has analgesic potential, but pentazocine is more potent analgesic than EELSR." @default.
- W2911383577 created "2019-02-21" @default.
- W2911383577 creator A5025981638 @default.
- W2911383577 creator A5044066844 @default.
- W2911383577 date "2019-01-01" @default.
- W2911383577 modified "2023-09-26" @default.
- W2911383577 title "Comparative study of analgesic activity of Lagenaria siceraria root extract with pentazocine in albino mice" @default.
- W2911383577 doi "https://doi.org/10.5455/njppp.2019.9.0100912012019" @default.
- W2911383577 hasPublicationYear "2019" @default.
- W2911383577 type Work @default.
- W2911383577 sameAs 2911383577 @default.
- W2911383577 citedByCount "1" @default.
- W2911383577 countsByYear W29113835772022 @default.
- W2911383577 crossrefType "journal-article" @default.
- W2911383577 hasAuthorship W2911383577A5025981638 @default.
- W2911383577 hasAuthorship W2911383577A5044066844 @default.
- W2911383577 hasConcept C2777397205 @default.
- W2911383577 hasConcept C2780802079 @default.
- W2911383577 hasConcept C2780820201 @default.
- W2911383577 hasConcept C42219234 @default.
- W2911383577 hasConcept C71924100 @default.
- W2911383577 hasConcept C98274493 @default.
- W2911383577 hasConceptScore W2911383577C2777397205 @default.
- W2911383577 hasConceptScore W2911383577C2780802079 @default.
- W2911383577 hasConceptScore W2911383577C2780820201 @default.
- W2911383577 hasConceptScore W2911383577C42219234 @default.
- W2911383577 hasConceptScore W2911383577C71924100 @default.
- W2911383577 hasConceptScore W2911383577C98274493 @default.
- W2911383577 hasIssue "3" @default.
- W2911383577 hasLocation W29113835771 @default.
- W2911383577 hasOpenAccess W2911383577 @default.
- W2911383577 hasPrimaryLocation W29113835771 @default.
- W2911383577 hasRelatedWork W1968332203 @default.
- W2911383577 hasRelatedWork W2006026205 @default.
- W2911383577 hasRelatedWork W2026651181 @default.
- W2911383577 hasRelatedWork W2042347764 @default.
- W2911383577 hasRelatedWork W2063136461 @default.
- W2911383577 hasRelatedWork W2068371707 @default.
- W2911383577 hasRelatedWork W2186238469 @default.
- W2911383577 hasRelatedWork W2376378358 @default.
- W2911383577 hasRelatedWork W2418781394 @default.
- W2911383577 hasRelatedWork W437079688 @default.
- W2911383577 hasVolume "9" @default.
- W2911383577 isParatext "false" @default.
- W2911383577 isRetracted "false" @default.
- W2911383577 magId "2911383577" @default.
- W2911383577 workType "article" @default.