Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911438570> ?p ?o ?g. }
- W2911438570 endingPage "31" @default.
- W2911438570 startingPage "18" @default.
- W2911438570 abstract "Chronic alcohol consumption increases the susceptibility to infectious diseases by compromising the immune system. Cytomegalovirus infection is common in humans and usually is asymptomatic in immunocompetent people. However, it can induce life-threatening medical complications in immunocompromised individuals such as alcoholics. How chronic alcohol consumption exacerbates cytomegalovirus infection is not known. Herein, we used a mouse cytomegalovirus model to study the underlying cellular and molecular mechanism. We found that alcohol consumption increased viral titers in spleen after 4 days of infection, enhanced body weight loss and inhibited splenomegaly during the acute phase of infection. Blood level of IFN-β, splenic IFN-γ and granzyme B-producing NK cells were lower in alcohol-consuming mice than in water-drinking mice at 12 hours after viral infection. Moreover, alcohol consumption decreased IL-15-producing DC after 36 hours infection, inhibited NK cell, specifically Ly49H+ NK cell maturation and proliferation 3-6 days after viral infection. Surprisingly, alcohol consumption enhanced NK cell and CD8+ T-cell continuous activation and increased granzyme B-producing cells. However, alcohol consumption decreased the expression of perforin in spleen and liver. Taken together, chronic alcohol consumption exacerbates cytomegalovirus infection via impairing nonspecific and specific NK cell activation, specifically IFN-γ and perforin production." @default.
- W2911438570 created "2019-02-21" @default.
- W2911438570 creator A5003759585 @default.
- W2911438570 creator A5011014503 @default.
- W2911438570 creator A5045145471 @default.
- W2911438570 creator A5070743427 @default.
- W2911438570 date "2018-11-26" @default.
- W2911438570 modified "2023-09-26" @default.
- W2911438570 title "Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice" @default.
- W2911438570 cites W1547920084 @default.
- W2911438570 cites W1580179014 @default.
- W2911438570 cites W1636051718 @default.
- W2911438570 cites W1957027480 @default.
- W2911438570 cites W1966280572 @default.
- W2911438570 cites W1966315835 @default.
- W2911438570 cites W1968028452 @default.
- W2911438570 cites W1980096748 @default.
- W2911438570 cites W1982084822 @default.
- W2911438570 cites W1987737741 @default.
- W2911438570 cites W1989417682 @default.
- W2911438570 cites W1990593861 @default.
- W2911438570 cites W1991308016 @default.
- W2911438570 cites W1999421885 @default.
- W2911438570 cites W2003565653 @default.
- W2911438570 cites W2019009873 @default.
- W2911438570 cites W2023258269 @default.
- W2911438570 cites W2034894138 @default.
- W2911438570 cites W2037608249 @default.
- W2911438570 cites W2040385463 @default.
- W2911438570 cites W2049678425 @default.
- W2911438570 cites W2057127638 @default.
- W2911438570 cites W2087555703 @default.
- W2911438570 cites W2088304195 @default.
- W2911438570 cites W2092090684 @default.
- W2911438570 cites W2095372870 @default.
- W2911438570 cites W2095548329 @default.
- W2911438570 cites W2100122909 @default.
- W2911438570 cites W2107179964 @default.
- W2911438570 cites W2109450812 @default.
- W2911438570 cites W2115782810 @default.
- W2911438570 cites W2123256114 @default.
- W2911438570 cites W2126263017 @default.
- W2911438570 cites W2132872826 @default.
- W2911438570 cites W2134438797 @default.
- W2911438570 cites W2134470782 @default.
- W2911438570 cites W2135793489 @default.
- W2911438570 cites W2138755493 @default.
- W2911438570 cites W2139549411 @default.
- W2911438570 cites W2146193551 @default.
- W2911438570 cites W2147558961 @default.
- W2911438570 cites W2148343285 @default.
- W2911438570 cites W2151121322 @default.
- W2911438570 cites W2159757524 @default.
- W2911438570 cites W2165894667 @default.
- W2911438570 cites W2166332877 @default.
- W2911438570 cites W2171306408 @default.
- W2911438570 cites W2202901642 @default.
- W2911438570 cites W2300312663 @default.
- W2911438570 cites W2554583968 @default.
- W2911438570 cites W2740001104 @default.
- W2911438570 cites W2911438570 @default.
- W2911438570 cites W811514720 @default.
- W2911438570 doi "https://doi.org/10.1096/fba.1019" @default.
- W2911438570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6996384" @default.
- W2911438570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32123809" @default.
- W2911438570 hasPublicationYear "2018" @default.
- W2911438570 type Work @default.
- W2911438570 sameAs 2911438570 @default.
- W2911438570 citedByCount "2" @default.
- W2911438570 countsByYear W29114385702018 @default.
- W2911438570 countsByYear W29114385702022 @default.
- W2911438570 crossrefType "journal-article" @default.
- W2911438570 hasAuthorship W2911438570A5003759585 @default.
- W2911438570 hasAuthorship W2911438570A5011014503 @default.
- W2911438570 hasAuthorship W2911438570A5045145471 @default.
- W2911438570 hasAuthorship W2911438570A5070743427 @default.
- W2911438570 hasBestOaLocation W29114385701 @default.
- W2911438570 hasConcept C159047783 @default.
- W2911438570 hasConcept C167672396 @default.
- W2911438570 hasConcept C183193105 @default.
- W2911438570 hasConcept C203014093 @default.
- W2911438570 hasConcept C2522874641 @default.
- W2911438570 hasConcept C2776062744 @default.
- W2911438570 hasConcept C2776409557 @default.
- W2911438570 hasConcept C2777732132 @default.
- W2911438570 hasConcept C2780380082 @default.
- W2911438570 hasConcept C2780727368 @default.
- W2911438570 hasConcept C2780931953 @default.
- W2911438570 hasConcept C71924100 @default.
- W2911438570 hasConcept C86803240 @default.
- W2911438570 hasConcept C8891405 @default.
- W2911438570 hasConceptScore W2911438570C159047783 @default.
- W2911438570 hasConceptScore W2911438570C167672396 @default.
- W2911438570 hasConceptScore W2911438570C183193105 @default.
- W2911438570 hasConceptScore W2911438570C203014093 @default.
- W2911438570 hasConceptScore W2911438570C2522874641 @default.
- W2911438570 hasConceptScore W2911438570C2776062744 @default.
- W2911438570 hasConceptScore W2911438570C2776409557 @default.