Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911444968> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2911444968 endingPage "414a" @default.
- W2911444968 startingPage "414a" @default.
- W2911444968 abstract "Tumor cell structures that have long been hypothesized as necessary for metastasis are invadopodia, invasive protrusions rich in structural proteins (Tks5, actin), adhesion proteins (eg. integrin β1), and metalloproteases, known to degrade the ECM proteins. By time-lapse microscopy, we observe that the Slow phenotype consists of temporal integration of two oscillating states: i. Invadopodia state, in which a cell is relatively sessile while it assembles invadopodia and degrades ECM; ii. Locomotion state. Importantly, the Invadopodia state only occurs in early G1, whereas the Locomotion state can be seen throughout the entire cell cycle, suggesting that the cell cycle controls invadopodia assembly. Towards elucidating the mechanism of state oscillations, we devised a mathematical model and engineered different levels of ECM cross-linking in 2D or 3D environments, discovering that state oscillation frequencies show a biphasic trend to linearly increasing levels of ECM cross-linking. We further show that in our model and experimentally, the oscillation dynamics between the states depend on ECM interactions with its major cellular receptor, integrin β1. Partial inhibition of the integrin β1 activity not only lowers the invadopodia-mediated ECM degradation, but can also eliminate Invadopodia state. In turn, cells spend more time in Locomotion state, increasing the net distance of cell migration. Our latest data demonstrates that an ECM degradation product, 60kDa fragment of laminin which binds integrin β1, can also act as a modulator of Locomotion-Invadopodia state balance. When released from the laminin network into the media, this fragment decreases invadopodia by 5-fold, simultaneously increasing both the speed and the time spent in cell migration. Overall, our data shows that invadopodia assembly is regulated by ECM components and ECM degradation products via integrin β1 activity, implying that breast cancer metastasis may be prevented by modulating integrin β1 activity levels." @default.
- W2911444968 created "2019-02-21" @default.
- W2911444968 creator A5016173955 @default.
- W2911444968 creator A5018164904 @default.
- W2911444968 creator A5075675985 @default.
- W2911444968 date "2019-02-01" @default.
- W2911444968 modified "2023-09-26" @default.
- W2911444968 title "Invadopodia Dynamics is Regulated by ECM Cross-Linking" @default.
- W2911444968 doi "https://doi.org/10.1016/j.bpj.2018.11.2234" @default.
- W2911444968 hasPublicationYear "2019" @default.
- W2911444968 type Work @default.
- W2911444968 sameAs 2911444968 @default.
- W2911444968 citedByCount "0" @default.
- W2911444968 crossrefType "journal-article" @default.
- W2911444968 hasAuthorship W2911444968A5016173955 @default.
- W2911444968 hasAuthorship W2911444968A5018164904 @default.
- W2911444968 hasAuthorship W2911444968A5075675985 @default.
- W2911444968 hasBestOaLocation W29114449681 @default.
- W2911444968 hasConcept C121608353 @default.
- W2911444968 hasConcept C12554922 @default.
- W2911444968 hasConcept C1491633281 @default.
- W2911444968 hasConcept C185592680 @default.
- W2911444968 hasConcept C189165786 @default.
- W2911444968 hasConcept C195687474 @default.
- W2911444968 hasConcept C200786668 @default.
- W2911444968 hasConcept C2779814568 @default.
- W2911444968 hasConcept C54355233 @default.
- W2911444968 hasConcept C55493867 @default.
- W2911444968 hasConcept C85789140 @default.
- W2911444968 hasConcept C86803240 @default.
- W2911444968 hasConcept C95444343 @default.
- W2911444968 hasConcept C96232424 @default.
- W2911444968 hasConceptScore W2911444968C121608353 @default.
- W2911444968 hasConceptScore W2911444968C12554922 @default.
- W2911444968 hasConceptScore W2911444968C1491633281 @default.
- W2911444968 hasConceptScore W2911444968C185592680 @default.
- W2911444968 hasConceptScore W2911444968C189165786 @default.
- W2911444968 hasConceptScore W2911444968C195687474 @default.
- W2911444968 hasConceptScore W2911444968C200786668 @default.
- W2911444968 hasConceptScore W2911444968C2779814568 @default.
- W2911444968 hasConceptScore W2911444968C54355233 @default.
- W2911444968 hasConceptScore W2911444968C55493867 @default.
- W2911444968 hasConceptScore W2911444968C85789140 @default.
- W2911444968 hasConceptScore W2911444968C86803240 @default.
- W2911444968 hasConceptScore W2911444968C95444343 @default.
- W2911444968 hasConceptScore W2911444968C96232424 @default.
- W2911444968 hasIssue "3" @default.
- W2911444968 hasLocation W29114449681 @default.
- W2911444968 hasOpenAccess W2911444968 @default.
- W2911444968 hasPrimaryLocation W29114449681 @default.
- W2911444968 hasRelatedWork W1969959931 @default.
- W2911444968 hasRelatedWork W1982694172 @default.
- W2911444968 hasRelatedWork W1990723931 @default.
- W2911444968 hasRelatedWork W2101772576 @default.
- W2911444968 hasRelatedWork W2115780596 @default.
- W2911444968 hasRelatedWork W2128518557 @default.
- W2911444968 hasRelatedWork W2142715273 @default.
- W2911444968 hasRelatedWork W2523852475 @default.
- W2911444968 hasRelatedWork W2943826953 @default.
- W2911444968 hasRelatedWork W3048316964 @default.
- W2911444968 hasVolume "116" @default.
- W2911444968 isParatext "false" @default.
- W2911444968 isRetracted "false" @default.
- W2911444968 magId "2911444968" @default.
- W2911444968 workType "article" @default.