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• W2911455812 abstract "Introduction: Patients with cirrhosis from chronic hepatitis C virus (HCV) infection are at increased risk of developing varices. Many screening guidelines exist on how to manage and follow patients with varices. Patients who have attained sustained virologic response at 12 weeks (SVR-12) currently undergo surveillance EGD every 2-3 years provided that there are no other confounding factors that increase liver injury. Although recent research shows regression of fibrosis/cirrhosis and portal hypertension after hepatitis C virus (HCV) treatment, it is unclear if clinical improvements are seen on endoscopy. We hypothesize that varices do not subside after treatment of HCV in patients with cirrhosis and warrant continued close surveillance. Methods: A retrospective review of 957 patient charts was performed. 22 patients with chronic HCV cirrhosis were found to meet criteria of the study. We examined and compared endoscopy reports both prior to and after SVR. Findings such as variceal type, size, and treatments of varices prior to SVR were documented. Results: Follow-up EGD obtained after SVR ranged from 1 day to 2 years, with a mean of 12.5 months. Of the patients examined, 3 (13.6%) patients had variceal cure after one-year post HCV cure, 17 (77.3%) patients did not achieve variceal cure. Of those, 5 (29.4%) patients were greater than 1-year post HCV cure and 12 (70.6%) patients were within 1-year post HCV cure. 2 (9.1%) patients may have developed varices post cure within 1 year of SVR. Patients underwent either no treatment, beta blocker alone, banding alone, or beta blocker and banding as treatment for varices. There was no statistically significant difference between treatment regimens in terms of variceal cure. Conclusion: Attainment of SVR in HCV cirrhotic patients does not seem to significantly affect resolution of varices in the short term. This is possibly due to the extent of liver disease that was formed prior to cure. Our study is limited due to its retrospective design, short follow-up period, different variceal treatment methods, data gathered from multiple providers, and multiple EGD procedures causing intra and inter-observer variability. We suggest further long-term studies analyzing variceal progression in cirrhotic patients after HCV cure among different treatment modalities. For now, we advocate for continued close surveillance of varices even in patients with HCV cure." @default.
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• W2911455812 date "2017-10-01" @default.
• W2911455812 modified "2023-09-27" @default.
• W2911455812 title "Progression of Varices in Hepatitis C Patients After Achieving Sustained Virological Response" @default.
• W2911455812 doi "https://doi.org/10.14309/00000434-201710001-02697" @default.
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