FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911494316> ?p ?o ?g. }

• W2911494316 endingPage "2209" @default.
• W2911494316 startingPage "2200" @default.
• W2911494316 abstract "Secondary hemophagocytic lymphohistiocytosis (sHLH) is a highly mortal complication associated with sepsis. In adults, it is often seen in the setting of infections, especially viral infections, but the mechanisms that underlie pathogenesis are unknown. sHLH is characterized by a hyperinflammatory state and the presence hemophagocytosis. We found that sequential challenging of mice with a nonlethal dose of viral toll-like receptor (TLR) agonist followed by a nonlethal dose of TLR4 agonist, but not other permutations, produced a highly lethal state that recapitulates many aspects of human HLH. We found that this hyperinflammatory response could be recapitulated in vitro in bone marrow-derived macrophages. RNA sequencing analyses revealed dramatic up-regulation of the red-pulp macrophage lineage-defining transcription factor SpiC and its associated transcriptional program, which was also present in bone marrow macrophages sorted from patients with sHLH. Transcriptional profiling also revealed a unique metabolic transcriptional profile in these macrophages, and immunometabolic phenotyping revealed impaired mitochondrial function and oxidative metabolism and a reliance on glycolytic metabolism. Subsequently, we show that therapeutic administration of the glycolysis inhibitor 2-deoxyglucose was sufficient to rescue animals from HLH. Together, these data identify a potential mechanism for the pathogenesis of sHLH and a potentially useful therapeutic strategy for its treatment." @default.
• W2911494316 created "2019-02-21" @default.
• W2911494316 creator A5002746422 @default.
• W2911494316 creator A5040597705 @default.
• W2911494316 creator A5043081740 @default.
• W2911494316 creator A5044166041 @default.
• W2911494316 creator A5058311726 @default.
• W2911494316 creator A5059089726 @default.
• W2911494316 creator A5078070899 @default.
• W2911494316 date "2019-01-23" @default.
• W2911494316 modified "2023-09-30" @default.
• W2911494316 title "Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice" @default.
• W2911494316 cites W1652620147 @default.
• W2911494316 cites W1926352629 @default.
• W2911494316 cites W1965064177 @default.
• W2911494316 cites W1965810063 @default.
• W2911494316 cites W1966454211 @default.
• W2911494316 cites W1967868228 @default.
• W2911494316 cites W1975566288 @default.
• W2911494316 cites W1982376681 @default.
• W2911494316 cites W1983067071 @default.
• W2911494316 cites W1989036623 @default.
• W2911494316 cites W1989804575 @default.
• W2911494316 cites W1997941500 @default.
• W2911494316 cites W2003614717 @default.
• W2911494316 cites W2012437303 @default.
• W2911494316 cites W2019335338 @default.
• W2911494316 cites W2021223904 @default.
• W2911494316 cites W2026576172 @default.
• W2911494316 cites W2037552619 @default.
• W2911494316 cites W2040459416 @default.
• W2911494316 cites W2041308303 @default.
• W2911494316 cites W2043240738 @default.
• W2911494316 cites W2043948229 @default.
• W2911494316 cites W2047909468 @default.
• W2911494316 cites W2055727949 @default.
• W2911494316 cites W2065338876 @default.
• W2911494316 cites W2080827095 @default.
• W2911494316 cites W2087101282 @default.
• W2911494316 cites W2089430148 @default.
• W2911494316 cites W2089532303 @default.
• W2911494316 cites W2094647964 @default.
• W2911494316 cites W2100706488 @default.
• W2911494316 cites W2110137421 @default.
• W2911494316 cites W2119656037 @default.
• W2911494316 cites W2137652508 @default.
• W2911494316 cites W2140876277 @default.
• W2911494316 cites W2143012846 @default.
• W2911494316 cites W2151711712 @default.
• W2911494316 cites W2159698564 @default.
• W2911494316 cites W2162251899 @default.
• W2911494316 cites W2163067702 @default.
• W2911494316 cites W2163924836 @default.
• W2911494316 cites W2164925047 @default.
• W2911494316 cites W2188969807 @default.
• W2911494316 cites W2206617731 @default.
• W2911494316 cites W2220698190 @default.
• W2911494316 cites W2400128945 @default.
• W2911494316 cites W2403473377 @default.
• W2911494316 cites W2415427537 @default.
• W2911494316 cites W2417595397 @default.
• W2911494316 cites W2513994159 @default.
• W2911494316 cites W2582090837 @default.
• W2911494316 cites W2645674615 @default.
• W2911494316 cites W2782451473 @default.
• W2911494316 cites W2792450878 @default.
• W2911494316 cites W2802682690 @default.
• W2911494316 cites W2804159084 @default.
• W2911494316 cites W2891533504 @default.
• W2911494316 cites W2894989586 @default.
• W2911494316 doi "https://doi.org/10.1073/pnas.1820704116" @default.
• W2911494316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369774" @default.
• W2911494316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674681" @default.
• W2911494316 hasPublicationYear "2019" @default.
• W2911494316 type Work @default.
• W2911494316 sameAs 2911494316 @default.
• W2911494316 citedByCount "37" @default.
• W2911494316 countsByYear W29114943162019 @default.
• W2911494316 countsByYear W29114943162020 @default.
• W2911494316 countsByYear W29114943162021 @default.
• W2911494316 countsByYear W29114943162022 @default.
• W2911494316 countsByYear W29114943162023 @default.
• W2911494316 crossrefType "journal-article" @default.
• W2911494316 hasAuthorship W2911494316A5002746422 @default.
• W2911494316 hasAuthorship W2911494316A5040597705 @default.
• W2911494316 hasAuthorship W2911494316A5043081740 @default.
• W2911494316 hasAuthorship W2911494316A5044166041 @default.
• W2911494316 hasAuthorship W2911494316A5058311726 @default.
• W2911494316 hasAuthorship W2911494316A5059089726 @default.
• W2911494316 hasAuthorship W2911494316A5078070899 @default.
• W2911494316 hasBestOaLocation W29114943161 @default.
• W2911494316 hasConcept C126322002 @default.
• W2911494316 hasConcept C203014093 @default.
• W2911494316 hasConcept C2777363875 @default.
• W2911494316 hasConcept C2779079688 @default.
• W2911494316 hasConcept C2779134260 @default.
• W2911494316 hasConcept C2779382419 @default.
• W2911494316 hasConcept C2780007613 @default.

• next