FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911518744> ?p ?o ?g. }

• W2911518744 endingPage "143" @default.
• W2911518744 startingPage "132" @default.
• W2911518744 abstract "Crohn's disease (CD) is a chronic disorder of the gastrointestinal tract characterized by inflammation and intestinal epithelial injury. Loss of function mutations in the intracellular bacterial sensor NOD2 are major risk factors for the development of CD. In the absence of robust bacterial recognition by NOD2 an inflammatory cascade is initiated through alternative PRRs leading to CD. In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice. NLRP3 inflammasome formation was observed at a higher rate in NOD2-deficient small intestinal lamina propria cells after insult by DSS. NLRP3 complex formation led to an increase in IL-1β secretion in both the small intestine and colon of Nod2ko mice. This increase in IL-1β secretion in the intestine was attenuated by MCC950 leading to decreased disease severity in Nod2ko mice. Our work suggests that NLRP3 inflammasome activation may be a key driver of intestinal inflammation in the absence of functional NOD2. NLRP3 pathway inhibition can prevent intestinal inflammation in the absence of robust NOD2 signaling." @default.
• W2911518744 created "2019-02-21" @default.
• W2911518744 creator A5006619891 @default.
• W2911518744 creator A5007941572 @default.
• W2911518744 creator A5012467839 @default.
• W2911518744 creator A5021359372 @default.
• W2911518744 creator A5034345010 @default.
• W2911518744 creator A5041253397 @default.
• W2911518744 creator A5053494797 @default.
• W2911518744 creator A5061327923 @default.
• W2911518744 creator A5062689584 @default.
• W2911518744 creator A5067797480 @default.
• W2911518744 creator A5087519994 @default.
• W2911518744 date "2019-02-01" @default.
• W2911518744 modified "2023-10-16" @default.
• W2911518744 title "The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in <i>Nod2</i> knockout mice" @default.
• W2911518744 cites W1529674879 @default.
• W2911518744 cites W1642457845 @default.
• W2911518744 cites W1670573097 @default.
• W2911518744 cites W1857468674 @default.
• W2911518744 cites W1981197190 @default.
• W2911518744 cites W2001166572 @default.
• W2911518744 cites W2018983895 @default.
• W2911518744 cites W2021839438 @default.
• W2911518744 cites W2030000543 @default.
• W2911518744 cites W2034285706 @default.
• W2911518744 cites W2043667001 @default.
• W2911518744 cites W2056279562 @default.
• W2911518744 cites W2061664992 @default.
• W2911518744 cites W2066327704 @default.
• W2911518744 cites W2073731887 @default.
• W2911518744 cites W2075145828 @default.
• W2911518744 cites W2080906449 @default.
• W2911518744 cites W2088833470 @default.
• W2911518744 cites W2097875133 @default.
• W2911518744 cites W2106618843 @default.
• W2911518744 cites W2112708847 @default.
• W2911518744 cites W2113589707 @default.
• W2911518744 cites W2124351063 @default.
• W2911518744 cites W2137711346 @default.
• W2911518744 cites W2140637559 @default.
• W2911518744 cites W2140906887 @default.
• W2911518744 cites W2149400414 @default.
• W2911518744 cites W2152751713 @default.
• W2911518744 cites W2156256528 @default.
• W2911518744 cites W2166171121 @default.
• W2911518744 cites W2166209782 @default.
• W2911518744 cites W2168247834 @default.
• W2911518744 cites W2170024099 @default.
• W2911518744 cites W2370127743 @default.
• W2911518744 cites W2806590169 @default.
• W2911518744 doi "https://doi.org/10.1177/1753425919826367" @default.
• W2911518744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6830860" @default.
• W2911518744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30774010" @default.
• W2911518744 hasPublicationYear "2019" @default.
• W2911518744 type Work @default.
• W2911518744 sameAs 2911518744 @default.
• W2911518744 citedByCount "22" @default.
• W2911518744 countsByYear W29115187442020 @default.
• W2911518744 countsByYear W29115187442021 @default.
• W2911518744 countsByYear W29115187442022 @default.
• W2911518744 countsByYear W29115187442023 @default.
• W2911518744 crossrefType "journal-article" @default.
• W2911518744 hasAuthorship W2911518744A5006619891 @default.
• W2911518744 hasAuthorship W2911518744A5007941572 @default.
• W2911518744 hasAuthorship W2911518744A5012467839 @default.
• W2911518744 hasAuthorship W2911518744A5021359372 @default.
• W2911518744 hasAuthorship W2911518744A5034345010 @default.
• W2911518744 hasAuthorship W2911518744A5041253397 @default.
• W2911518744 hasAuthorship W2911518744A5053494797 @default.
• W2911518744 hasAuthorship W2911518744A5061327923 @default.
• W2911518744 hasAuthorship W2911518744A5062689584 @default.
• W2911518744 hasAuthorship W2911518744A5067797480 @default.
• W2911518744 hasAuthorship W2911518744A5087519994 @default.
• W2911518744 hasBestOaLocation W29115187441 @default.
• W2911518744 hasConcept C126322002 @default.
• W2911518744 hasConcept C134018914 @default.
• W2911518744 hasConcept C136449434 @default.
• W2911518744 hasConcept C139174496 @default.
• W2911518744 hasConcept C203014093 @default.
• W2911518744 hasConcept C2776914184 @default.
• W2911518744 hasConcept C2777209026 @default.
• W2911518744 hasConcept C2777310793 @default.
• W2911518744 hasConcept C2781071285 @default.
• W2911518744 hasConcept C3019368612 @default.
• W2911518744 hasConcept C49039625 @default.
• W2911518744 hasConcept C529295009 @default.
• W2911518744 hasConcept C54355233 @default.
• W2911518744 hasConcept C71924100 @default.
• W2911518744 hasConcept C7573103 @default.
• W2911518744 hasConcept C86803240 @default.
• W2911518744 hasConcept C8891405 @default.
• W2911518744 hasConceptScore W2911518744C126322002 @default.
• W2911518744 hasConceptScore W2911518744C134018914 @default.
• W2911518744 hasConceptScore W2911518744C136449434 @default.
• W2911518744 hasConceptScore W2911518744C139174496 @default.
• W2911518744 hasConceptScore W2911518744C203014093 @default.
• W2911518744 hasConceptScore W2911518744C2776914184 @default.

• next