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- W2911528081 abstract "Protein aggregation and inclusion body formationInclusion body formation have been a key causal phenomenon behind a majority of neurodegenerative disorders. Various approaches aimed at preventing the formation/elimination of protein aggregates are being developed to control these diseases. Molecular chaperones are a class of protein that not only direct the functionally relevant fold of the protein but also perform quality control against stress, misfolding/aggregation. Genes that encode molecular chaperones are induced and expressed in response to extreme stress conditions to “salvage” the cell by the “unfolded protein response” (UPR) signaling pathway. Here we describe in detail the various in vitro and in vivo assays involved in identifying the chaperone activity of proteins using human calnuc as a model protein. Calnuc is a Golgi resident, calcium-binding protein, identified as chaperone protein and is reported to protect the cells against the cytotoxicity caused by amyloidosis and ER stress. Calnuc is also reported to regulate Gαi activity and inflammation apart from the role of chaperoning against amyloid proteins." @default.
- W2911528081 created "2019-02-21" @default.
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- W2911528081 date "2019-01-01" @default.
- W2911528081 modified "2023-10-16" @default.
- W2911528081 title "Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo" @default.
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- W2911528081 doi "https://doi.org/10.1007/978-1-4939-9030-6_10" @default.
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