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- W2911536703 abstract "Alzheimer's disease is considered a disconnection syndrome, motivating the use of brain network measures to detect changes in whole-brain resting state functional connectivity (FC). We investigated changes in FC within and among resting state networks (RSN) across four different stages in the Alzheimer's disease continuum. FC changes were examined in two independent cohorts of individuals (84 and 58 individuals, respectively) each comprising control, subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia groups. For each participant, FC was computed as a matrix of Pearson correlations between pairs of time series from 278 gray matter brain regions. We determined significant differences in FC modular organization with two distinct approaches, network contingency analysis and multiresolution consensus clustering. Network contingency analysis identified RSN sub-blocks that differed significantly across clinical groups. Multiresolution consensus clustering identified differences in the stability of modules across multiple spatial scales. Significant modules were further tested for statistical association with memory and executive function cognitive domain scores. Across both analytic approaches and in both participant cohorts, the findings converged on a pattern of FC that varied systematically with diagnosis within the frontoparietal network (FP) and between the FP network and default mode network (DMN). Disturbances of modular organization were manifest as greater internal coherence of the FP network and stronger coupling between FP and DMN, resulting in less segregation of these two networks. Our findings suggest that the pattern of interactions within and between specific RSNs offers new insight into the functional disruption that occurs across the Alzheimer's disease spectrum." @default.
- W2911536703 created "2019-02-21" @default.
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- W2911536703 date "2019-01-01" @default.
- W2911536703 modified "2023-10-18" @default.
- W2911536703 title "Resting state network modularity along the prodromal late onset Alzheimer's disease continuum" @default.
- W2911536703 cites W1561100145 @default.
- W2911536703 cites W1596614913 @default.
- W2911536703 cites W1636800622 @default.
- W2911536703 cites W1687468892 @default.
- W2911536703 cites W1719469090 @default.
- W2911536703 cites W1760829075 @default.
- W2911536703 cites W1940423692 @default.
- W2911536703 cites W1963990344 @default.
- W2911536703 cites W1973776237 @default.
- W2911536703 cites W1979119850 @default.
- W2911536703 cites W1989962199 @default.
- W2911536703 cites W1990134753 @default.
- W2911536703 cites W1998268694 @default.
- W2911536703 cites W2003065863 @default.
- W2911536703 cites W2005933475 @default.
- W2911536703 cites W2006096283 @default.
- W2911536703 cites W2007572953 @default.
- W2911536703 cites W2011541551 @default.
- W2911536703 cites W2013393341 @default.
- W2911536703 cites W2029386843 @default.
- W2911536703 cites W2037267027 @default.
- W2911536703 cites W2042557239 @default.
- W2911536703 cites W2044984028 @default.
- W2911536703 cites W2055186021 @default.
- W2911536703 cites W2055345898 @default.
- W2911536703 cites W2062331496 @default.
- W2911536703 cites W2063435176 @default.
- W2911536703 cites W2067456724 @default.
- W2911536703 cites W2075220720 @default.
- W2911536703 cites W2084009541 @default.
- W2911536703 cites W2084892943 @default.
- W2911536703 cites W2085561705 @default.
- W2911536703 cites W2090495290 @default.
- W2911536703 cites W2091549362 @default.
- W2911536703 cites W2094426896 @default.
- W2911536703 cites W2095293504 @default.
- W2911536703 cites W2101048381 @default.
- W2911536703 cites W2104016179 @default.
- W2911536703 cites W2110000143 @default.
- W2911536703 cites W2112005505 @default.
- W2911536703 cites W2114302768 @default.
- W2911536703 cites W2122538793 @default.
- W2911536703 cites W2126650951 @default.
- W2911536703 cites W2126838454 @default.
- W2911536703 cites W2127048411 @default.
- W2911536703 cites W2131681506 @default.
- W2911536703 cites W2133903921 @default.
- W2911536703 cites W2134858198 @default.
- W2911536703 cites W2136435696 @default.
- W2911536703 cites W2138991775 @default.
- W2911536703 cites W2143285014 @default.
- W2911536703 cites W2143502460 @default.
- W2911536703 cites W2145729305 @default.
- W2911536703 cites W2164262344 @default.
- W2911536703 cites W2172263413 @default.
- W2911536703 cites W2196621485 @default.
- W2911536703 cites W2291815547 @default.
- W2911536703 cites W2324392087 @default.
- W2911536703 cites W2340175675 @default.
- W2911536703 cites W2412333115 @default.
- W2911536703 cites W2516213641 @default.
- W2911536703 cites W2520835145 @default.
- W2911536703 cites W2547736356 @default.
- W2911536703 cites W2557390385 @default.
- W2911536703 cites W2563999121 @default.
- W2911536703 cites W2564797465 @default.
- W2911536703 cites W2575359420 @default.
- W2911536703 cites W2606081028 @default.
- W2911536703 cites W2623603318 @default.
- W2911536703 cites W2737784620 @default.
- W2911536703 cites W2741112289 @default.
- W2911536703 cites W2745997312 @default.
- W2911536703 cites W2765906219 @default.
- W2911536703 cites W2769813710 @default.
- W2911536703 cites W2774400961 @default.
- W2911536703 cites W2963041679 @default.
- W2911536703 cites W2963499979 @default.