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- W2911546512 abstract "Cervical sympathetic chain controls sympathetic drive to the carotid baro- and chemo-sensors. Zucker fat rats (ZFRs) are a model of sleep apnea with both obstructive and central apneas. We hypothesized that electrical stimulation of the cervical sympathetic stimulation in anesthetized ZFRs will lead to improvement in airway patency and prevent the blood pressure drop during a hypoxic-hypercapnic challenge. Under urethane, male ZFRs (Age:16 wks, n=6), were instrumented for mean blood pressure (MAP), diaphragmatic and genioglossus electromyogram (EMG), and upper airway pressure (UAP) measurements. Both CSC were dissected, isolated and prepared for bipolar stimulation. ZFRs had a high incidence of sighs at baseline (room air) and exposure to hypoxic-hypercapnia exposure (10% O2, 8% CO2) for 1 min lead to increase in airway pressure (30% increase) and drop in blood pressure (40% decrease) (Panel A). Bilateral stimulation of CSC during hypoxic-hypercapnic challenge reduced the collapse of the airway and the bl..." @default.
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- W2911546512 date "2017-11-14" @default.
- W2911546512 modified "2023-09-24" @default.
- W2911546512 title "Abstract 20190: Cervical Sympathetic Chain Stimulation Attenuates the Hypoxic-Hypercapnic Response in Anesthetized Zucker-Fat Rats" @default.
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