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• W2911553513 abstract "Abstract Background and Aims Fibroblast growth factor 19 (FGF19) and fibroblast growth factor receptor 4 (FGFR4) signalling play critical roles in hepatocarcinogenesis. This study explored the potential of FGF19‐ and FGFR4‐related biomarkers in predicting early tumour recurrence (ETR) and survival in patients with resectable hepatocellular carcinoma (HCC). Methods We examined the mRNA expressions of FGF19 , FGFR4 , klotho‐beta ( KLB ), cyclin D1 ( CCND1 ) and FGF4 in 151 surgically resected, primary unifocal HCCs through quantitative real‐time polymerase chain reaction. Generalized additive models were fitted to detect nonlinear effects of continuous covariates and define thresholds of biomarker expressions. Univariate and multivariate analyses were performed to evaluate prognostic values of these biomarkers for tumour recurrence and patient survival. Results Overexpression of FGF19, FGFR4, KLB, CCND1 and FGF4 mRNA was detected in 40%, 32%, 26%, 15% and 35% of 151 tumours respectively. ETR was the strongest prognostic factor predicting worse overall survival (hazard ratio [HR], 5.678; 95% confidence interval, 3.7‐8.713; P < 0.001). Furthermore, we revealed that mRNA expression levels of KLB (HR, 3.857; P = 0.021) and FGF19 (HR, 3.248; P = 0.017) were significantly associated with the occurrence of ETR. Conclusions Frequent overexpression of FGF19 / FGFR4 ‐related biomarkers was detected in resectable HCC. Expression levels of KLB and FGF19 may determine patient survival outcomes through their effects on ETR." @default.
• W2911553513 created "2019-02-21" @default.
• W2911553513 creator A5004699298 @default.
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• W2911553513 date "2019-07-11" @default.
• W2911553513 modified "2023-10-17" @default.
• W2911553513 title "<i>Klotho‐beta</i> and <i>fibroblast growth factor 19</i> expression correlates with early recurrence of resectable hepatocellular carcinoma" @default.
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• W2911553513 doi "https://doi.org/10.1111/liv.14055" @default.
• W2911553513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30698907" @default.
• W2911553513 hasPublicationYear "2019" @default.
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