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• W2911566788 endingPage "1396" @default.
• W2911566788 startingPage "1383" @default.
• W2911566788 abstract "Abstract Although primary humoral responses are vital to durable immunity, fine-tuning is critical to preventing catastrophes such as autoimmunity, chronic inflammation, and lymphomagenesis. MicroRNA (miRNA)-mediated regulation is particularly well suited for fine-tuning roles in physiology. Expression of clustered paralogous miR-182, miR-96, and miR-183 (collectively, 183c) is robustly induced upon B cell activation, entry into the germinal center, and plasmablast differentiation. 183cGT/GT mice lacking 183c miRNA expression exhibit largely normal primary humoral responses, encompassing class switch recombination, affinity maturation, and germinal center reaction, as well as plasmablast differentiation. Our rigorous analysis included ex vivo class switch recombination and plasmablast differentiation models as well as in vivo immunization with thymus-dependent and thymus-independent Ags. Our work sways the debate concerning the role of miR-182 in plasmablast differentiation, strongly suggesting that 183c miRNAs are dispensable. In the process, we present a valuable framework for systematic evaluation of primary humoral responses. Finally, our work bolsters the notion of robustness in miRNA:target interaction networks and advocates a paradigm shift in miRNA studies." @default.
• W2911566788 created "2019-02-21" @default.
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• W2911566788 date "2019-03-01" @default.
• W2911566788 modified "2023-09-24" @default.
• W2911566788 title "The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses" @default.
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• W2911566788 doi "https://doi.org/10.4049/jimmunol.1800071" @default.
• W2911566788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6986270" @default.
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