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• W2911594119 endingPage "780" @default.
• W2911594119 startingPage "771" @default.
• W2911594119 abstract "The circadian clock and the ~24 h rhythms it generates are essential in maintaining regular tissue functioning. At the molecular level, the circadian clock comprises a core set of rhythmically expressed genes and gene products that are able to drive rhythmic expression of other genes to generate overt circadian rhythms. It has recently come to light that perturbations of circadian rhythms contribute to the development of pathological states such as cancer, and altered expression and/or regulation of circadian clock genes has been identified in multiple tumour types. This review summarises the important role the circadian system plays in regulating cellular processes, including the cell cycle, apoptosis, DNA repair, the epithelial-to-mesenchymal transition, metabolism and immunity and how its dysregulation has widespread implications and could be a critical player in the development of cancer. Understanding its role in cancer development is important for the field chronotherapy, where the timing of chemotherapy administration is optimised based on differences in circadian clock functioning in normal and cancer cells. This has been found to influence the patient response, minimising the side effects commonly associated with chemotherapy. © 2019 IUBMB Life, 2019." @default.
• W2911594119 created "2019-02-21" @default.
• W2911594119 creator A5012684686 @default.
• W2911594119 creator A5016391601 @default.
• W2911594119 creator A5030073309 @default.
• W2911594119 creator A5076221040 @default.
• W2911594119 date "2019-01-23" @default.
• W2911594119 modified "2023-10-16" @default.
• W2911594119 title "The tumour suppressing role of the circadian clock" @default.
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