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• W2911595899 abstract "Stromal cells in spleen organise tissue into red pulp, white pulp and marginal zone and also interact with hematopoietic cells to regulate immune responses. This study has used phenotypic information of a previously described spleen stromal cell line called 5G3, which supports restricted hematopoiesis in vitro, to identify an equivalent stromal cell subset in vivo and to test its capacity to support hematopoiesis. Using stromal cell fractionation, phenotypic analysis, as well as cell growth and hematopoietic support assays, the Sca-1+gp38+Thy1.2+CD29+CD51+ fraction of spleen stroma has been identified as an equivalent stromal subset resembling the 5G3 cell counterpart. While heterogeneity may still exist within that subset, it has been shown to have superior hematopoietic support capacity compared with the 5G3 cell line, and all other spleen stromal cell fractions tested." @default.
• W2911595899 created "2019-02-21" @default.
• W2911595899 creator A5039022151 @default.
• W2911595899 creator A5051004770 @default.
• W2911595899 date "2019-01-24" @default.
• W2911595899 modified "2023-09-25" @default.
• W2911595899 title "Identification of Stromal Cells in Spleen Which Support Myelopoiesis" @default.
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• W2911595899 doi "https://doi.org/10.3389/fcell.2019.00001" @default.
• W2911595899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6354566" @default.
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