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- W2911633741 endingPage "1067" @default.
- W2911633741 startingPage "1058" @default.
- W2911633741 abstract "Ampullary malignancies belong to the family of periampullary tumors. The significant premalignant potential and strategic location of ampullary neoplasms makes them unique. Typically, ampullary tumors are classified as benign and malignant. Adenocarcinoma accounts for 75% of ampullary neoplasms, which is followed by benign adenomas (20%) and neuroendocrine tumors (5%). Villous and tubulovillous adenomas are the most common benign lesions. Both benign and malignant ampullary tumors arise in the setting of a genetic syndrome or spontaneously. Familial adenomatous polyposis is the most common genetic predisposition. Because ampullary adenomas have a premalignant potential and an occult focus of carcinoma may be present within an adenoma, the primary concern in evaluating ampullary lesions is to rule out malignancy. The diagnosis is usually established by the combination of radiology, endoscopy, and histology. Most ampullary lesions are apparent endoscopically and the ampulla is best examined and biopsied with a side-viewing duodenoscope. Cross-sectional imaging is highly accurate to detect distant metastasis and endoscopic ultrasonography is used in preoperative staging of ampullary malignancy. Although ampullary adenomas are classified as benign, they have a tendency to undergo malignant transformation. The true ampullary cancer is usually difficult to distinguish from other periampullary malignancies and is usually diagnosed at an earlier stage, resulting in having a better prognosis compared to periampullary cancers originating from the bile or pancreatic duct. Therefore, aggressive diagnostic and therapeutic approach is needed for these lesions." @default.
- W2911633741 created "2019-02-21" @default.
- W2911633741 creator A5002220086 @default.
- W2911633741 creator A5027534317 @default.
- W2911633741 date "2018-02-12" @default.
- W2911633741 modified "2023-10-16" @default.
- W2911633741 title "Adenoma and Adenocarcinoma of the Ampulla of Vater" @default.
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