FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911636822> ?p ?o ?g. }

• W2911636822 abstract "15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyses the conversion of prostaglandin E2 to a keto metabolite. The expression of 15-PGDH is ubiquitously repressed in various human malignancies. However, the molecular mechanisms underlying down-regulation of 15-PGDH expression remain largely unknown. 15-Deoxy-△12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of peroxisome proliferator-activated receptor γ, has been reported to have anti-inflammatory and anticarcinogenic activities. In the present study, we have found that 15d-PGJ2 induces expression and catalytic activity of 15-PGDH in human breast cancer (MDA-MB-231) cells. 15d-PGJ2 decreased the level of CpG methylation in the 15-PGDH promoter in MDA-MB-231 cells as determined by the bisulphite genome sequencing and methyl-specific PCR. 15d-PGJ2 inhibited the catalytic activity of methyltransferase 1 (DNMT1) but did not influence its expression. Biotinylated 15d-PGJ2 directly interacted with DNMT1 and reduced its catalytic activity. Chromatin-immunoprecipitation analysis revealed that 15d-PGJ2 significantly attenuated DNMT1 binding to the activator protein-1 transcription factor present in the 15-PGDH promoter region. A nonelectrophilic analogue 9,10-dihydro-15d-PGJ2 failed to suppress the methylation of CpG islands present in 15-PGDH promoter and did not affect both DNMT1 activity and 15-PGDH expression. These findings suggest that the α,β-unsaturated carbonyl group present in 15d-PGJ2 is essential for its inactivation on DNMT1 and expression of 15-PGDH. In conclusion, 15d-PGJ2 plays as a hypomethylating agent through direct interaction with DNMT1 and consequently suppresses DNMT1-mediated hypermethylation of 15-PGDH promoter, leading to up-regulation of 15-PGDH expression." @default.
• W2911636822 created "2019-02-21" @default.
• W2911636822 creator A5028705589 @default.
• W2911636822 creator A5029703998 @default.
• W2911636822 creator A5029755579 @default.
• W2911636822 creator A5031280773 @default.
• W2911636822 creator A5037531553 @default.
• W2911636822 creator A5037780092 @default.
• W2911636822 creator A5061532156 @default.
• W2911636822 creator A5072092583 @default.
• W2911636822 creator A5075895899 @default.
• W2911636822 date "2019-03-01" @default.
• W2911636822 modified "2023-09-24" @default.
• W2911636822 title "15-Deoxy-Δ12,14-prostaglandin J2 up-regulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation" @default.
• W2911636822 cites W1033623824 @default.
• W2911636822 cites W1970050679 @default.
• W2911636822 cites W1976644988 @default.
• W2911636822 cites W1980410293 @default.
• W2911636822 cites W1983769980 @default.
• W2911636822 cites W1983855553 @default.
• W2911636822 cites W1986866765 @default.
• W2911636822 cites W1990078462 @default.
• W2911636822 cites W1991952322 @default.
• W2911636822 cites W1996267589 @default.
• W2911636822 cites W2001335885 @default.
• W2911636822 cites W2009121506 @default.
• W2911636822 cites W2010027879 @default.
• W2911636822 cites W2010287588 @default.
• W2911636822 cites W2014306540 @default.
• W2911636822 cites W2014623973 @default.
• W2911636822 cites W2024570090 @default.
• W2911636822 cites W2029484950 @default.
• W2911636822 cites W2029686419 @default.
• W2911636822 cites W2040257851 @default.
• W2911636822 cites W2048783110 @default.
• W2911636822 cites W2062594503 @default.
• W2911636822 cites W2075214050 @default.
• W2911636822 cites W2081279521 @default.
• W2911636822 cites W2084582367 @default.
• W2911636822 cites W2089731541 @default.
• W2911636822 cites W2093315645 @default.
• W2911636822 cites W2094402002 @default.
• W2911636822 cites W2096330673 @default.
• W2911636822 cites W2107038650 @default.
• W2911636822 cites W2111598062 @default.
• W2911636822 cites W2114479549 @default.
• W2911636822 cites W2123816220 @default.
• W2911636822 cites W2141383117 @default.
• W2911636822 cites W2147266862 @default.
• W2911636822 cites W2149816812 @default.
• W2911636822 cites W2152656267 @default.
• W2911636822 cites W2165760845 @default.
• W2911636822 cites W2167948090 @default.
• W2911636822 cites W2170339479 @default.
• W2911636822 cites W2593691302 @default.
• W2911636822 cites W2615780060 @default.
• W2911636822 cites W2809371389 @default.
• W2911636822 cites W2895513089 @default.
• W2911636822 cites W2895929816 @default.
• W2911636822 cites W2897972464 @default.
• W2911636822 cites W81399563 @default.
• W2911636822 doi "https://doi.org/10.1080/10715762.2019.1576867" @default.
• W2911636822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717608" @default.
• W2911636822 hasPublicationYear "2019" @default.
• W2911636822 type Work @default.
• W2911636822 sameAs 2911636822 @default.
• W2911636822 citedByCount "2" @default.
• W2911636822 countsByYear W29116368222019 @default.
• W2911636822 countsByYear W29116368222020 @default.
• W2911636822 crossrefType "journal-article" @default.
• W2911636822 hasAuthorship W2911636822A5028705589 @default.
• W2911636822 hasAuthorship W2911636822A5029703998 @default.
• W2911636822 hasAuthorship W2911636822A5029755579 @default.
• W2911636822 hasAuthorship W2911636822A5031280773 @default.
• W2911636822 hasAuthorship W2911636822A5037531553 @default.
• W2911636822 hasAuthorship W2911636822A5037780092 @default.
• W2911636822 hasAuthorship W2911636822A5061532156 @default.
• W2911636822 hasAuthorship W2911636822A5072092583 @default.
• W2911636822 hasAuthorship W2911636822A5075895899 @default.
• W2911636822 hasConcept C101762097 @default.
• W2911636822 hasConcept C104317684 @default.
• W2911636822 hasConcept C134320426 @default.
• W2911636822 hasConcept C140173407 @default.
• W2911636822 hasConcept C150194340 @default.
• W2911636822 hasConcept C153911025 @default.
• W2911636822 hasConcept C170493617 @default.
• W2911636822 hasConcept C175211621 @default.
• W2911636822 hasConcept C185592680 @default.
• W2911636822 hasConcept C190727270 @default.
• W2911636822 hasConcept C2779979206 @default.
• W2911636822 hasConcept C2780664492 @default.
• W2911636822 hasConcept C33288867 @default.
• W2911636822 hasConcept C552990157 @default.
• W2911636822 hasConcept C55493867 @default.
• W2911636822 hasConcept C86339819 @default.
• W2911636822 hasConcept C86803240 @default.
• W2911636822 hasConcept C88045685 @default.
• W2911636822 hasConcept C91965660 @default.
• W2911636822 hasConceptScore W2911636822C101762097 @default.
• W2911636822 hasConceptScore W2911636822C104317684 @default.

• next