FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911645555> ?p ?o ?g. }

• W2911645555 endingPage "S1311" @default.
• W2911645555 startingPage "S1310" @default.
• W2911645555 abstract "Pseudomelanosis duodeni (PD) is a rare condition that when seen on endoscopy can promote apprehension. With the increasing rise of endoscopy on the aging patient population, it is important to be familiar with the characteristics and natural history of this condition. A 67 year old female with history of Diabetes Mellitus and Heart Failure presented with gradual fatigue. She denied abdominal pain, hematemesis, hematochezia or melena. Medication history was notable for ferrous sulphate and hydralazine. Examination was normal. Labs showed a Hb 5 g/dl, MCV 70.7 fl, ferritin 25 ng/ml, serum iron 30 ug/dL, iron saturation 7% and a TIBC 401mcg/dl. The patient received a blood transfusion and GI was consulted. Endoscopy showed diffuse black speckled mucosa in the esophagus, stomach and duodenum (Fig 1&2). Duodenal Biopsies were taken with a cold forceps. Results showed pigment deposition in macrophages of the lamina propria (Fig 3). Staining identified the pigment to be iron and PD was diagnosed. PD is a rare condition of uncertain significance, first described in 1976. Its true incidence and prevalence is yet to be established. PD occurs predominantly in females in the 6th-7th decades of life. The term “pseudomelanosis” was first introduced as initially the pigment was interpreted as melanin. However it has now been demonstrated to be ferrous sulfide. PD is typically found incidentally on endoscopy and does not have any hallmark clinical features. It has been associated with end stage renal disease, diabetes, multiple medications and gastrointestinal bleeding. Our patient was on iron and hydralazine both of which have been linked to PD. The most common site involved is the duodenum with esophageal and stomach involvement even rarer. Typically on endoscopy the proximal duodenal mucosa is speckled with multiple flat, small dark spots. Histologically these lesions will show macrophages laden with a characteristic brown-black granular pigment within the lamina propria of the villi on microscopy. Histochemical stains for iron (Perl's prussian blue) or melanin (Masson-Fontana) may be positive however this is uneven and unpredictable. Its peculiar appearance can lead to a diagnostic dilemma with differentials including metastatic melanoma, charcoal or hemosiderosis. There is no gold standard therapy, with no particular follow up recommended. Prognosis of PD is yet to be determined however the lack of cytological atypia on histology is reassuring.Figure: Showing PD involvement in the Esophagus.Figure: Showing the hallmark appearance of PD with black speckled appearance in the Duodenum.Figure: Showing Duodenal Biopsy on H&E stain and Iron Stain, positive for Iron within the Macrophages." @default.
• W2911645555 created "2019-02-21" @default.
• W2911645555 creator A5005992644 @default.
• W2911645555 creator A5007804008 @default.
• W2911645555 creator A5016227073 @default.
• W2911645555 creator A5019781698 @default.
• W2911645555 creator A5059207347 @default.
• W2911645555 creator A5083228573 @default.
• W2911645555 date "2017-10-01" @default.
• W2911645555 modified "2023-09-25" @default.
• W2911645555 title "Pseudomelanosis Duodeni: Is it Just an Incidental Finding?" @default.
• W2911645555 doi "https://doi.org/10.14309/00000434-201710001-02407" @default.
• W2911645555 hasPublicationYear "2017" @default.
• W2911645555 type Work @default.
• W2911645555 sameAs 2911645555 @default.
• W2911645555 citedByCount "0" @default.
• W2911645555 crossrefType "journal-article" @default.
• W2911645555 hasAuthorship W2911645555A5005992644 @default.
• W2911645555 hasAuthorship W2911645555A5007804008 @default.
• W2911645555 hasAuthorship W2911645555A5016227073 @default.
• W2911645555 hasAuthorship W2911645555A5019781698 @default.
• W2911645555 hasAuthorship W2911645555A5059207347 @default.
• W2911645555 hasAuthorship W2911645555A5083228573 @default.
• W2911645555 hasConcept C126322002 @default.
• W2911645555 hasConcept C141071460 @default.
• W2911645555 hasConcept C142724271 @default.
• W2911645555 hasConcept C2776809568 @default.
• W2911645555 hasConcept C2777310793 @default.
• W2911645555 hasConcept C2777424391 @default.
• W2911645555 hasConcept C2778080469 @default.
• W2911645555 hasConcept C2778451229 @default.
• W2911645555 hasConcept C2779663748 @default.
• W2911645555 hasConcept C2780955771 @default.
• W2911645555 hasConcept C2908647359 @default.
• W2911645555 hasConcept C529295009 @default.
• W2911645555 hasConcept C71924100 @default.
• W2911645555 hasConcept C90924648 @default.
• W2911645555 hasConcept C99454951 @default.
• W2911645555 hasConceptScore W2911645555C126322002 @default.
• W2911645555 hasConceptScore W2911645555C141071460 @default.
• W2911645555 hasConceptScore W2911645555C142724271 @default.
• W2911645555 hasConceptScore W2911645555C2776809568 @default.
• W2911645555 hasConceptScore W2911645555C2777310793 @default.
• W2911645555 hasConceptScore W2911645555C2777424391 @default.
• W2911645555 hasConceptScore W2911645555C2778080469 @default.
• W2911645555 hasConceptScore W2911645555C2778451229 @default.
• W2911645555 hasConceptScore W2911645555C2779663748 @default.
• W2911645555 hasConceptScore W2911645555C2780955771 @default.
• W2911645555 hasConceptScore W2911645555C2908647359 @default.
• W2911645555 hasConceptScore W2911645555C529295009 @default.
• W2911645555 hasConceptScore W2911645555C71924100 @default.
• W2911645555 hasConceptScore W2911645555C90924648 @default.
• W2911645555 hasConceptScore W2911645555C99454951 @default.
• W2911645555 hasLocation W29116455551 @default.
• W2911645555 hasOpenAccess W2911645555 @default.
• W2911645555 hasPrimaryLocation W29116455551 @default.
• W2911645555 hasRelatedWork W2014683800 @default.
• W2911645555 hasRelatedWork W2015375562 @default.
• W2911645555 hasRelatedWork W2045296248 @default.
• W2911645555 hasRelatedWork W2131289884 @default.
• W2911645555 hasRelatedWork W2162004127 @default.
• W2911645555 hasRelatedWork W2254835537 @default.
• W2911645555 hasRelatedWork W2360492516 @default.
• W2911645555 hasRelatedWork W2378136848 @default.
• W2911645555 hasRelatedWork W4317618861 @default.
• W2911645555 hasRelatedWork W4319160958 @default.
• W2911645555 hasVolume "112" @default.
• W2911645555 isParatext "false" @default.
• W2911645555 isRetracted "false" @default.
• W2911645555 magId "2911645555" @default.
• W2911645555 workType "article" @default.