FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911649304> ?p ?o ?g. }

• W2911649304 endingPage "S82" @default.
• W2911649304 startingPage "S82" @default.
• W2911649304 abstract "Introduction: Colectomy affects the anatomical structures of the gastrointestinal tract that may make patients more susceptible to certain motility disorders such as microbial overgrowth. The purpose of this investigation was to determine if colectomy is significantly associated with development of small intestinal bacterial (SIBO) or fungal (SIFO) overgrowth. Methods: A cohort of patients with unexplained chronic GI symptoms and a history colectomy were compared against a similar cohort of patients without colectomy. All patients had undergone negative GI evaluations (including endoscopy and abdominal imaging). SIBO/SIFO was determined by using either glucose breath testing or distal duodenal aspiration with culture for aerobic, anaerobic, and fungal organisms. Data were compared between the two groups. Results: One hundred patients were identified, of which 50 (m/f=9/41) had undergone colectomy and 50 (m/f=38/12) had intact colon. Mean patient age was 51.1 years (range: 17-88), 79% females, and a mean duration of symptoms of 6.5 years, and no difference between groups. In the colectomy group, the most frequent type of resection was partial (N=28), followed by subtotal (N=11), and total (N=11) colectomy respectively. Patients who had undergone prior colectomy were significantly more likely to have SIBO (62% vs 32%; P=0.0005) or SIFO (42% vs 12%; P=0.004) when compared to controls without colectomy. Culture aspirate testing revealed significantly greater predominance of aerobic organisms (45% vs 17%; P=0.008) in patients with colectomy, including primarily Streptococcus, Escherichia coli, Klebsiella pneumoniae, and fungal Candida species. Colectomy was also associated with greater gastrointestinal symptom severity including diarrhea (4.6 vs 3.0; P=0.029) and vomiting (2.5 vs 0.3; P<0.001) as assessed by the Likert scale. Also in the colectomy group, patients had significantly greater severity of belching (1.0 vs 0.0; P<0.001) and gas (5.5 vs 3.0; P=0.028) compared to those without. Conclusion: We found significantly higher prevalence of SIBO and SIFO in patients with unexplained GI symptoms following colectomy when compared to matched control group. The neo-anastomosis between the small and large bowel breaks down natural barriers that prevent translocation of bacteria from the colon, thereby leading to colonization and development of SIBO/SIFO. Appropriate recognition and treatment with antibiotics could help many of these patients.Figure" @default.
• W2911649304 created "2019-02-21" @default.
• W2911649304 creator A5006738594 @default.
• W2911649304 creator A5017818369 @default.
• W2911649304 creator A5039411633 @default.
• W2911649304 creator A5050061160 @default.
• W2911649304 creator A5061809394 @default.
• W2911649304 creator A5064911207 @default.
• W2911649304 date "2017-10-01" @default.
• W2911649304 modified "2023-09-27" @default.
• W2911649304 title "Colectomy Is Significantly Associated With the Development of SIBO and SIFO" @default.
• W2911649304 doi "https://doi.org/10.14309/00000434-201710001-00162" @default.
• W2911649304 hasPublicationYear "2017" @default.
• W2911649304 type Work @default.
• W2911649304 sameAs 2911649304 @default.
• W2911649304 citedByCount "0" @default.
• W2911649304 crossrefType "journal-article" @default.
• W2911649304 hasAuthorship W2911649304A5006738594 @default.
• W2911649304 hasAuthorship W2911649304A5017818369 @default.
• W2911649304 hasAuthorship W2911649304A5039411633 @default.
• W2911649304 hasAuthorship W2911649304A5050061160 @default.
• W2911649304 hasAuthorship W2911649304A5061809394 @default.
• W2911649304 hasAuthorship W2911649304A5064911207 @default.
• W2911649304 hasConcept C126322002 @default.
• W2911649304 hasConcept C141071460 @default.
• W2911649304 hasConcept C2776667177 @default.
• W2911649304 hasConcept C2779134260 @default.
• W2911649304 hasConcept C2780479503 @default.
• W2911649304 hasConcept C42407357 @default.
• W2911649304 hasConcept C5140985 @default.
• W2911649304 hasConcept C71924100 @default.
• W2911649304 hasConcept C72563966 @default.
• W2911649304 hasConcept C90924648 @default.
• W2911649304 hasConceptScore W2911649304C126322002 @default.
• W2911649304 hasConceptScore W2911649304C141071460 @default.
• W2911649304 hasConceptScore W2911649304C2776667177 @default.
• W2911649304 hasConceptScore W2911649304C2779134260 @default.
• W2911649304 hasConceptScore W2911649304C2780479503 @default.
• W2911649304 hasConceptScore W2911649304C42407357 @default.
• W2911649304 hasConceptScore W2911649304C5140985 @default.
• W2911649304 hasConceptScore W2911649304C71924100 @default.
• W2911649304 hasConceptScore W2911649304C72563966 @default.
• W2911649304 hasConceptScore W2911649304C90924648 @default.
• W2911649304 hasLocation W29116493041 @default.
• W2911649304 hasOpenAccess W2911649304 @default.
• W2911649304 hasPrimaryLocation W29116493041 @default.
• W2911649304 hasRelatedWork W2056666990 @default.
• W2911649304 hasRelatedWork W2062132000 @default.
• W2911649304 hasRelatedWork W2086156447 @default.
• W2911649304 hasRelatedWork W2171692737 @default.
• W2911649304 hasRelatedWork W2263850275 @default.
• W2911649304 hasRelatedWork W2414966063 @default.
• W2911649304 hasRelatedWork W2978765478 @default.
• W2911649304 hasRelatedWork W4210249856 @default.
• W2911649304 hasRelatedWork W1655786854 @default.
• W2911649304 hasRelatedWork W2337243043 @default.
• W2911649304 hasVolume "112" @default.
• W2911649304 isParatext "false" @default.
• W2911649304 isRetracted "false" @default.
• W2911649304 magId "2911649304" @default.
• W2911649304 workType "article" @default.