FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911650363> ?p ?o ?g. }

• W2911650363 endingPage "L797" @default.
• W2911650363 startingPage "L784" @default.
• W2911650363 abstract "A defining characteristic of pulmonary hypertension (PH) is the extensive remodeling of pulmonary arteries (PAs), which results in progressive increases in vascular resistance and stiffness and eventual failure of the right ventricle. There is no cure for PH and identification of novel molecular mechanisms that underlie increased proliferation, reduced apoptosis, and excessive extracellular matrix production in pulmonary artery smooth muscle cells (PASMCs) is a vital objective. Galectin-3 (Gal-3) is a chimeric lectin and potent driver of many aspects of fibrosis, but its role in regulating PASMC behavior in PH remains poorly understood. Herein, we evaluated the importance of increased Gal-3 expression and signaling on PA vascular remodeling and cardiopulmonary function in experimental models of PH. Gal-3 expression was quantified by qRT-PCR, immunoblotting, and immunofluorescence imaging, and its functional role was assessed by specific Gal-3 inhibitors and CRISPR/Cas9-mediated knockout of Gal-3 in the rat. In rat models of PH, we observed increased Gal-3 expression in PASMCs, which stimulated migration and resistance to apoptosis, whereas silencing or genetic deletion reduced cellular migration and PA fibrosis and increased apoptosis. Gal-3 inhibitors attenuated and reversed PA remodeling and fibrosis, as well as hemodynamic indices in monocrotaline (MCT)-treated rats in vivo. These results were supported by genetic deletion of Gal-3 in both MCT and Sugen Hypoxia rat models. In conclusion, our results suggest that elevated Gal-3 levels contribute to inappropriate PA remodeling in PH by enhancing multiple profibrotic mechanisms. Therapeutic strategies targeting Gal-3 may be of benefit in the treatment of PH." @default.
• W2911650363 created "2019-02-21" @default.
• W2911650363 creator A5012285751 @default.
• W2911650363 creator A5022764628 @default.
• W2911650363 creator A5026793153 @default.
• W2911650363 creator A5028028489 @default.
• W2911650363 creator A5030568693 @default.
• W2911650363 creator A5031911753 @default.
• W2911650363 creator A5044478152 @default.
• W2911650363 creator A5044782405 @default.
• W2911650363 creator A5045452010 @default.
• W2911650363 creator A5049445146 @default.
• W2911650363 creator A5053487946 @default.
• W2911650363 creator A5068639127 @default.
• W2911650363 creator A5069070315 @default.
• W2911650363 creator A5075774578 @default.
• W2911650363 creator A5077116014 @default.
• W2911650363 creator A5079440495 @default.
• W2911650363 creator A5080813882 @default.
• W2911650363 creator A5080825662 @default.
• W2911650363 creator A5087769804 @default.
• W2911650363 creator A5090264314 @default.
• W2911650363 date "2019-05-01" @default.
• W2911650363 modified "2023-10-18" @default.
• W2911650363 title "Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis" @default.
• W2911650363 cites W1554696296 @default.
• W2911650363 cites W1789328091 @default.
• W2911650363 cites W1952846996 @default.
• W2911650363 cites W1967641344 @default.
• W2911650363 cites W1967989660 @default.
• W2911650363 cites W1972974730 @default.
• W2911650363 cites W1986081466 @default.
• W2911650363 cites W1986347648 @default.
• W2911650363 cites W1988027744 @default.
• W2911650363 cites W1992596514 @default.
• W2911650363 cites W1997544440 @default.
• W2911650363 cites W1999871489 @default.
• W2911650363 cites W2002534521 @default.
• W2911650363 cites W2008090487 @default.
• W2911650363 cites W2013283042 @default.
• W2911650363 cites W2015075375 @default.
• W2911650363 cites W2023703380 @default.
• W2911650363 cites W2032570439 @default.
• W2911650363 cites W2035506819 @default.
• W2911650363 cites W2037821829 @default.
• W2911650363 cites W2038147892 @default.
• W2911650363 cites W2049373116 @default.
• W2911650363 cites W2050988768 @default.
• W2911650363 cites W2051016429 @default.
• W2911650363 cites W2058111781 @default.
• W2911650363 cites W2080950003 @default.
• W2911650363 cites W2085040223 @default.
• W2911650363 cites W2090158969 @default.
• W2911650363 cites W2093626739 @default.
• W2911650363 cites W2094188666 @default.
• W2911650363 cites W2105471059 @default.
• W2911650363 cites W2109257372 @default.
• W2911650363 cites W2109652800 @default.
• W2911650363 cites W2110586410 @default.
• W2911650363 cites W2123124648 @default.
• W2911650363 cites W2123248199 @default.
• W2911650363 cites W2134723308 @default.
• W2911650363 cites W2135164569 @default.
• W2911650363 cites W2136978968 @default.
• W2911650363 cites W2141016294 @default.
• W2911650363 cites W2143795945 @default.
• W2911650363 cites W2145836265 @default.
• W2911650363 cites W2146234408 @default.
• W2911650363 cites W2146421447 @default.
• W2911650363 cites W2147787157 @default.
• W2911650363 cites W2150405879 @default.
• W2911650363 cites W2158838633 @default.
• W2911650363 cites W2165946847 @default.
• W2911650363 cites W2195137866 @default.
• W2911650363 cites W2271932771 @default.
• W2911650363 cites W2278070412 @default.
• W2911650363 cites W2524790117 @default.
• W2911650363 cites W2535633630 @default.
• W2911650363 cites W2554718094 @default.
• W2911650363 cites W2559213835 @default.
• W2911650363 cites W2560711417 @default.
• W2911650363 cites W2586336210 @default.
• W2911650363 cites W2602025655 @default.
• W2911650363 cites W2740615734 @default.
• W2911650363 cites W2777753472 @default.
• W2911650363 cites W2788499244 @default.
• W2911650363 cites W2790194507 @default.
• W2911650363 cites W2806003448 @default.
• W2911650363 cites W2886206473 @default.
• W2911650363 cites W2901432278 @default.
• W2911650363 cites W2904631278 @default.
• W2911650363 cites W3103761932 @default.
• W2911650363 cites W341655912 @default.
• W2911650363 doi "https://doi.org/10.1152/ajplung.00186.2018" @default.
• W2911650363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589585" @default.
• W2911650363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30724100" @default.
• W2911650363 hasPublicationYear "2019" @default.
• W2911650363 type Work @default.

• next