FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911662779> ?p ?o ?g. }

• W2911662779 endingPage "10" @default.
• W2911662779 startingPage "1" @default.
• W2911662779 abstract "Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis. Any remedies that inhibit the activation of PSCs can be potential candidates for therapeutic strategies in pancreatic fibrosis-related pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Our study is aimed at exploring the protective effect of coenzyme Q10 (CoQ10) against pancreatic fibrosis.Pancreatic fibrosis was induced by 20% L-arginine (250 mg/100 g) at 1 h intervals twice per week for 8 weeks in C57BL/6 mice. CoQ10 was administered for 4 weeks. Isolated primary PSCs from C57BL/6 mice were treated with 100 μM CoQ10 for 72 h, as well as Rosup and specific inhibitors. The effects of CoQ10 on the activation of PSCs, autophagy, collagen deposition, histological changes, and oxidative stress were analyzed by western blotting, biochemical estimations, immunofluorescence staining, and hematoxylin-eosin, Masson, and Sirius red staining, as well as with a reactive oxygen species (ROS) assay.Pretreatment and posttreatment of CoQ10 decreased autophagy, activation of PSCs, oxidative stress, histological changes, and collagen deposition in the CP mouse model. In primary PSCs, expression levels of p-PI3K, p-AKT, and p-mTOR were upregulated with CoQ10. A rescue experiment using specific inhibitors of the PI3K-AKT-mTOR pathway demonstrated that the PI3K-AKT-mTOR signaling pathway was the underlying mechanism by which CoQ10 ameliorated fibrosis. With the addition of Rosup, expression levels of the autophagy biomarkers LC3 and Atg5 were elevated. Meanwhile, the levels of p-PI3K, p-AKT, and p-mTOR were lower.Our findings demonstrated that CoQ10 alleviates pancreatic fibrosis by the ROS-triggered PI3K/AKT/mTOR signaling pathway. CoQ10 may be a therapeutic candidate for antifibrotic methods." @default.
• W2911662779 created "2019-02-21" @default.
• W2911662779 creator A5004507884 @default.
• W2911662779 creator A5026258550 @default.
• W2911662779 creator A5032378268 @default.
• W2911662779 creator A5057153132 @default.
• W2911662779 creator A5066463949 @default.
• W2911662779 creator A5069341396 @default.
• W2911662779 creator A5082841104 @default.
• W2911662779 creator A5085225833 @default.
• W2911662779 date "2019-02-07" @default.
• W2911662779 modified "2023-10-16" @default.
• W2911662779 title "Coenzyme Q10 Ameliorates Pancreatic Fibrosis via the ROS-Triggered mTOR Signaling Pathway" @default.
• W2911662779 cites W1193855731 @default.
• W2911662779 cites W1968593380 @default.
• W2911662779 cites W1973271241 @default.
• W2911662779 cites W1991724550 @default.
• W2911662779 cites W1993525187 @default.
• W2911662779 cites W2014927084 @default.
• W2911662779 cites W2035027225 @default.
• W2911662779 cites W2046816983 @default.
• W2911662779 cites W2050859161 @default.
• W2911662779 cites W2059738518 @default.
• W2911662779 cites W2064327102 @default.
• W2911662779 cites W2085727390 @default.
• W2911662779 cites W2120595804 @default.
• W2911662779 cites W2155510164 @default.
• W2911662779 cites W2339956215 @default.
• W2911662779 cites W2566425328 @default.
• W2911662779 cites W2576087201 @default.
• W2911662779 cites W2581766553 @default.
• W2911662779 cites W2586440279 @default.
• W2911662779 cites W2593026369 @default.
• W2911662779 cites W2604859963 @default.
• W2911662779 cites W2757509826 @default.
• W2911662779 cites W2807686905 @default.
• W2911662779 cites W2811471450 @default.
• W2911662779 cites W4244129533 @default.
• W2911662779 cites W4377471897 @default.
• W2911662779 cites W48153192 @default.
• W2911662779 cites W5450568 @default.
• W2911662779 doi "https://doi.org/10.1155/2019/8039694" @default.
• W2911662779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6383547" @default.
• W2911662779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30881598" @default.
• W2911662779 hasPublicationYear "2019" @default.
• W2911662779 type Work @default.
• W2911662779 sameAs 2911662779 @default.
• W2911662779 citedByCount "32" @default.
• W2911662779 countsByYear W29116627792019 @default.
• W2911662779 countsByYear W29116627792020 @default.
• W2911662779 countsByYear W29116627792021 @default.
• W2911662779 countsByYear W29116627792022 @default.
• W2911662779 countsByYear W29116627792023 @default.
• W2911662779 crossrefType "journal-article" @default.
• W2911662779 hasAuthorship W2911662779A5004507884 @default.
• W2911662779 hasAuthorship W2911662779A5026258550 @default.
• W2911662779 hasAuthorship W2911662779A5032378268 @default.
• W2911662779 hasAuthorship W2911662779A5057153132 @default.
• W2911662779 hasAuthorship W2911662779A5066463949 @default.
• W2911662779 hasAuthorship W2911662779A5069341396 @default.
• W2911662779 hasAuthorship W2911662779A5082841104 @default.
• W2911662779 hasAuthorship W2911662779A5085225833 @default.
• W2911662779 hasBestOaLocation W29116627791 @default.
• W2911662779 hasConcept C126322002 @default.
• W2911662779 hasConcept C134018914 @default.
• W2911662779 hasConcept C185592680 @default.
• W2911662779 hasConcept C190283241 @default.
• W2911662779 hasConcept C203522944 @default.
• W2911662779 hasConcept C2776151105 @default.
• W2911662779 hasConcept C2779384338 @default.
• W2911662779 hasConcept C2779770810 @default.
• W2911662779 hasConcept C2780559512 @default.
• W2911662779 hasConcept C2781000418 @default.
• W2911662779 hasConcept C48349386 @default.
• W2911662779 hasConcept C502942594 @default.
• W2911662779 hasConcept C55493867 @default.
• W2911662779 hasConcept C62478195 @default.
• W2911662779 hasConcept C71924100 @default.
• W2911662779 hasConcept C75217442 @default.
• W2911662779 hasConcept C86554907 @default.
• W2911662779 hasConceptScore W2911662779C126322002 @default.
• W2911662779 hasConceptScore W2911662779C134018914 @default.
• W2911662779 hasConceptScore W2911662779C185592680 @default.
• W2911662779 hasConceptScore W2911662779C190283241 @default.
• W2911662779 hasConceptScore W2911662779C203522944 @default.
• W2911662779 hasConceptScore W2911662779C2776151105 @default.
• W2911662779 hasConceptScore W2911662779C2779384338 @default.
• W2911662779 hasConceptScore W2911662779C2779770810 @default.
• W2911662779 hasConceptScore W2911662779C2780559512 @default.
• W2911662779 hasConceptScore W2911662779C2781000418 @default.
• W2911662779 hasConceptScore W2911662779C48349386 @default.
• W2911662779 hasConceptScore W2911662779C502942594 @default.
• W2911662779 hasConceptScore W2911662779C55493867 @default.
• W2911662779 hasConceptScore W2911662779C62478195 @default.
• W2911662779 hasConceptScore W2911662779C71924100 @default.
• W2911662779 hasConceptScore W2911662779C75217442 @default.
• W2911662779 hasConceptScore W2911662779C86554907 @default.
• W2911662779 hasFunder F4320321001 @default.

• next