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• W2911675194 endingPage "19.2019" @default.
• W2911675194 startingPage "ENEURO.0007" @default.
• W2911675194 abstract "Low-threshold mechanosensitive C fibers (C-LTMRs) that express the vesicular glutamate transporter VGLUT3 are thought to signal affective touch, and may also play a role in mechanical allodynia. However, the nature of the central termination of C-LTMRs in the dorsal horn remains largely unexplored. Here, we used light and electron microscopy in combination with VGLUT3 immunolabeling as a marker of C-LTMR terminations to investigate this issue. VGLUT3 + C-LTMRs formed central terminals of Type II glomeruli in the inner part of lamina II of the dorsal horn, often establishing multiple asymmetric synapses with postsynaptic dendrites but also participating in synaptic configurations with presynaptic axons and dendrites. Unexpectedly, essentially all VGLUT3 + C-LTMR terminals showed substantial VGLUT1 expression in the rat, whereas such terminals in mice lacked VGLUT1. Most VGLUT3 + C-LTMR terminals exhibited weak-to-moderate VGLUT2 expression. Further, C-LTMR terminals formed numerous synapses with excitatory protein kinase Cγ (PKCγ) interneurons and inhibitory parvalbumin neurons, whereas synapses with calretinin neurons were scarce. C-LTMR terminals rarely if ever established synapses with neurokinin 1 receptor (NK1R)-possessing dendrites traversing lamina II. Thus, VGLUT3 + C-LTMR terminals appear to largely correspond to neurofilament-lacking central terminals of Type II glomeruli in inner lamina II and can thus be identified at the ultrastructural level by morphological criteria. The participation of C-LTMR terminals in Type II glomeruli involving diverse populations of interneuron indicates highly complex modes of integration of C-LTMR mediated signaling in the dorsal horn. Furthermore, differences in VGLUT1 expression indicate distinct species differences in synaptic physiology of C-LTMR terminals." @default.
• W2911675194 created "2019-02-21" @default.
• W2911675194 creator A5034285165 @default.
• W2911675194 creator A5068836593 @default.
• W2911675194 date "2019-01-01" @default.
• W2911675194 modified "2023-09-25" @default.
• W2911675194 title "Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord" @default.
• W2911675194 cites W1514349633 @default.
• W2911675194 cites W1519975209 @default.
• W2911675194 cites W1523392700 @default.
• W2911675194 cites W1540607329 @default.
• W2911675194 cites W1592037135 @default.
• W2911675194 cites W1603496942 @default.
• W2911675194 cites W1620667569 @default.
• W2911675194 cites W1630907922 @default.
• W2911675194 cites W1904625121 @default.
• W2911675194 cites W1938233678 @default.
• W2911675194 cites W1962358525 @default.
• W2911675194 cites W1969046927 @default.
• W2911675194 cites W1969742525 @default.
• W2911675194 cites W1975312927 @default.
• W2911675194 cites W1976946357 @default.
• W2911675194 cites W1983542297 @default.
• W2911675194 cites W1987613139 @default.
• W2911675194 cites W1988548196 @default.
• W2911675194 cites W1989789207 @default.
• W2911675194 cites W1995574861 @default.
• W2911675194 cites W1998272805 @default.
• W2911675194 cites W1998650202 @default.
• W2911675194 cites W1998679264 @default.
• W2911675194 cites W2000414319 @default.
• W2911675194 cites W2004052351 @default.
• W2911675194 cites W2012903416 @default.
• W2911675194 cites W2016195705 @default.
• W2911675194 cites W2020180345 @default.
• W2911675194 cites W2032603698 @default.
• W2911675194 cites W2033072655 @default.
• W2911675194 cites W2037755318 @default.
• W2911675194 cites W2046176229 @default.
• W2911675194 cites W2053026848 @default.
• W2911675194 cites W2054041622 @default.
• W2911675194 cites W2056492757 @default.
• W2911675194 cites W2059635921 @default.
• W2911675194 cites W2061874226 @default.
• W2911675194 cites W2062195812 @default.
• W2911675194 cites W2063428082 @default.
• W2911675194 cites W2064071741 @default.
• W2911675194 cites W2065874844 @default.
• W2911675194 cites W2065989997 @default.
• W2911675194 cites W2075449089 @default.
• W2911675194 cites W2079458882 @default.
• W2911675194 cites W2085052553 @default.
• W2911675194 cites W2093368672 @default.
• W2911675194 cites W2095397861 @default.
• W2911675194 cites W2096828953 @default.
• W2911675194 cites W2103302443 @default.
• W2911675194 cites W2105278734 @default.
• W2911675194 cites W2115568736 @default.
• W2911675194 cites W2115761515 @default.
• W2911675194 cites W2117469871 @default.
• W2911675194 cites W2124790162 @default.
• W2911675194 cites W2144626580 @default.
• W2911675194 cites W2145473020 @default.
• W2911675194 cites W2146321492 @default.
• W2911675194 cites W2151711638 @default.
• W2911675194 cites W2153213393 @default.
• W2911675194 cites W2162056974 @default.
• W2911675194 cites W2165453482 @default.
• W2911675194 cites W2169099154 @default.
• W2911675194 cites W2295921085 @default.
• W2911675194 cites W2381891294 @default.
• W2911675194 cites W2401690763 @default.
• W2911675194 cites W2415803194 @default.
• W2911675194 cites W2531893059 @default.
• W2911675194 cites W2561827989 @default.
• W2911675194 cites W2588506331 @default.
• W2911675194 cites W2592930474 @default.
• W2911675194 cites W2770225090 @default.
• W2911675194 cites W2922168592 @default.
• W2911675194 cites W3023584199 @default.
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• W2911675194 doi "https://doi.org/10.1523/eneuro.0007-19.2019" @default.
• W2911675194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6378328" @default.
• W2911675194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30783617" @default.
• W2911675194 hasPublicationYear "2019" @default.
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