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- W2911682017 abstract "With the development of technologies such as genomes, proteomes, and metabolomes, the number of potential therapeutic targets are accessible. However, it is an indispensable puzzle for screening optimal drugs in innumerable candidate compounds with high specificity and sensitivity for these target. Herein, we propose a strategy using structured illumination microscopy (SIM) to screen and discover drugs at nanoscale morphology in living cell. Our results show that this strategy not only can distinguish the interaction behavior between mitochondria and lysosomes such as mitochondria-lysosomes contact (MLC) and mitophagy events[1], but also can evaluate the role of different genes (such as ATG13, FIP200 and PENTA) in these events. Furthermore, it is a visualized evidence to judge the effect of different drugs for MLC and mitophgay events at nanoscale morphology. Our findings thus illustrate a novel perspective for using SIM to visualize the biological function of candidate drugs at the organelle level in living cells, which can increase the success rate of drug discovery, and even shorten the cycle of novel drug development. [1] Q X Chen, C Z Jin, X T Shao, R L Guan, Z Q Tian, C R Wang, F Liu, P X Ling, J L Guan, L N Ji, F S Wang, H Chao, and J J Diao, Small, 1802166 (2018)." @default.
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- W2911682017 date "2019-02-01" @default.
- W2911682017 modified "2023-10-16" @default.
- W2911682017 title "Drug Screening and Discovery Strategies at Nanoscale Morphology using Structured Illumination Microscopy" @default.
- W2911682017 doi "https://doi.org/10.1016/j.bpj.2018.11.1449" @default.
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