Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911688399> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2911688399 endingPage "3025" @default.
- W2911688399 startingPage "3021" @default.
- W2911688399 abstract "Abstract LEF1 antisense RNA 1 (LEF1‐AS1) is an antisense long non‐coding RNA encoded in the lymphoid enhancer‐binding factor 1 (LEF1) locus. LEF1‐AS1 is a conserved transcript dysregulated in hematopoiesis. This study aimed to functionally characterize the role of this transcript in myeloid malignancy and explore a possible regulatory effect of LEF1‐AS1 upon LEF1. We show that LEF1‐AS1 is highly expressed in normal hematopoietic stem cells but barely detectable in myeloid malignant cell lines. Additionally, bone marrow cells from myelodysplastic syndrome (n=12) and acute myeloid malignancy patients (n=28) expressed significantly reduced levels of LEF1‐AS1 compared to healthy controls (n=15). Artificial LEF1‐AS1 over‐expression inhibited proliferation in HL60 and led to an upregulation of tumor suppressors p21 and p27, and reduced ERK1/2 activation. Unexpectedly, no underlying modulation of LEF1 was detected. Ectopic expression of LEF1‐AS1 also inhibited proliferation in HELA, a cell line lacking endogenous expression of LEF1, supporting a LEF1‐independent mechanism. Additionally, transient over‐expression of LEF1‐AS1 in AML patient cells also led to reduced proliferation and colony formation capacity. We used a mass spectrometry‐based proteomics approach. Proteomic quantification identified the modulation of an important metabolic regulator, Fumarase, and concomitant accumulation of the metabolite fumarate." @default.
- W2911688399 created "2019-02-21" @default.
- W2911688399 creator A5027194150 @default.
- W2911688399 creator A5027300502 @default.
- W2911688399 creator A5041549390 @default.
- W2911688399 creator A5081834539 @default.
- W2911688399 date "2019-02-15" @default.
- W2911688399 modified "2023-09-25" @default.
- W2911688399 title "LEF1‐AS1, long non‐coding RNA, inhibits proliferation in myeloid malignancy" @default.
- W2911688399 cites W1514085189 @default.
- W2911688399 cites W1612748954 @default.
- W2911688399 cites W1898990505 @default.
- W2911688399 cites W1965780501 @default.
- W2911688399 cites W2018835220 @default.
- W2911688399 cites W2033662995 @default.
- W2911688399 cites W2050576379 @default.
- W2911688399 cites W2083455895 @default.
- W2911688399 cites W2085999210 @default.
- W2911688399 cites W2141027725 @default.
- W2911688399 cites W2146573461 @default.
- W2911688399 cites W2149060273 @default.
- W2911688399 cites W2588146519 @default.
- W2911688399 cites W2734558750 @default.
- W2911688399 doi "https://doi.org/10.1111/jcmm.14152" @default.
- W2911688399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6433713" @default.
- W2911688399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770626" @default.
- W2911688399 hasPublicationYear "2019" @default.
- W2911688399 type Work @default.
- W2911688399 sameAs 2911688399 @default.
- W2911688399 citedByCount "19" @default.
- W2911688399 countsByYear W29116883992019 @default.
- W2911688399 countsByYear W29116883992020 @default.
- W2911688399 countsByYear W29116883992021 @default.
- W2911688399 countsByYear W29116883992022 @default.
- W2911688399 countsByYear W29116883992023 @default.
- W2911688399 crossrefType "journal-article" @default.
- W2911688399 hasAuthorship W2911688399A5027194150 @default.
- W2911688399 hasAuthorship W2911688399A5027300502 @default.
- W2911688399 hasAuthorship W2911688399A5041549390 @default.
- W2911688399 hasAuthorship W2911688399A5081834539 @default.
- W2911688399 hasBestOaLocation W29116883991 @default.
- W2911688399 hasConcept C104317684 @default.
- W2911688399 hasConcept C109159458 @default.
- W2911688399 hasConcept C127561419 @default.
- W2911688399 hasConcept C153911025 @default.
- W2911688399 hasConcept C202416437 @default.
- W2911688399 hasConcept C2778729363 @default.
- W2911688399 hasConcept C2779282312 @default.
- W2911688399 hasConcept C28328180 @default.
- W2911688399 hasConcept C502942594 @default.
- W2911688399 hasConcept C54355233 @default.
- W2911688399 hasConcept C62112901 @default.
- W2911688399 hasConcept C62203573 @default.
- W2911688399 hasConcept C67705224 @default.
- W2911688399 hasConcept C81885089 @default.
- W2911688399 hasConcept C86803240 @default.
- W2911688399 hasConcept C95444343 @default.
- W2911688399 hasConceptScore W2911688399C104317684 @default.
- W2911688399 hasConceptScore W2911688399C109159458 @default.
- W2911688399 hasConceptScore W2911688399C127561419 @default.
- W2911688399 hasConceptScore W2911688399C153911025 @default.
- W2911688399 hasConceptScore W2911688399C202416437 @default.
- W2911688399 hasConceptScore W2911688399C2778729363 @default.
- W2911688399 hasConceptScore W2911688399C2779282312 @default.
- W2911688399 hasConceptScore W2911688399C28328180 @default.
- W2911688399 hasConceptScore W2911688399C502942594 @default.
- W2911688399 hasConceptScore W2911688399C54355233 @default.
- W2911688399 hasConceptScore W2911688399C62112901 @default.
- W2911688399 hasConceptScore W2911688399C62203573 @default.
- W2911688399 hasConceptScore W2911688399C67705224 @default.
- W2911688399 hasConceptScore W2911688399C81885089 @default.
- W2911688399 hasConceptScore W2911688399C86803240 @default.
- W2911688399 hasConceptScore W2911688399C95444343 @default.
- W2911688399 hasFunder F4320320997 @default.
- W2911688399 hasIssue "4" @default.
- W2911688399 hasLocation W29116883991 @default.
- W2911688399 hasLocation W29116883992 @default.
- W2911688399 hasLocation W29116883993 @default.
- W2911688399 hasOpenAccess W2911688399 @default.
- W2911688399 hasPrimaryLocation W29116883991 @default.
- W2911688399 hasRelatedWork W1988878360 @default.
- W2911688399 hasRelatedWork W2296384492 @default.
- W2911688399 hasRelatedWork W2614825660 @default.
- W2911688399 hasRelatedWork W2774992434 @default.
- W2911688399 hasRelatedWork W2980955790 @default.
- W2911688399 hasRelatedWork W3010357773 @default.
- W2911688399 hasRelatedWork W3206974297 @default.
- W2911688399 hasRelatedWork W4225702286 @default.
- W2911688399 hasRelatedWork W4235347117 @default.
- W2911688399 hasRelatedWork W4293568743 @default.
- W2911688399 hasVolume "23" @default.
- W2911688399 isParatext "false" @default.
- W2911688399 isRetracted "false" @default.
- W2911688399 magId "2911688399" @default.
- W2911688399 workType "article" @default.