Matches in SemOpenAlex for { <https://semopenalex.org/work/W2911696307> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2911696307 endingPage "iii" @default.
- W2911696307 startingPage "ii" @default.
- W2911696307 abstract "This study assesses the effects of peripheral or intrathecal pre-treatment or post-treatment with µ, δ, κ and nociceptin/orphanin FQ (NOP) opioid receptor agonists (morphine, U-50488 [trans-(±)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride], DADLE [D-Ala2-Leu5-enkephalin] and nociceptin, respectively) on formalin-induced secondary mechanical allodynia and hyperalgesia in rats. 1% Formalin injection produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term tactile secondary allodynia and hyperalgesia. Neither peripheral (into the formalin-injected paw) nor intrathecal morphine post-treatment reversed formalin-induced secondary allodynia and hyperalgesia. In contrast, morphine pre-treatment prevented the development of these pain behaviors. Intrathecal and peripheral post- but not pre-treatment with U-50488 or DADLE significantly reduced secondary allodynia and hyperalgesia. Interestingly, nociceptin reduced both pain behaviors regardless of the administration site or treatment time. Local antinociceptive effects of morphine, DADLE, U-50488 or nociceptin were blocked by naltrexone, naltrindole, 5-guanidinonaltrindole and [Nphe1]nociceptin(1–13)NH2, respectively. These results suggest that the long-term nociceptive behaviors induced by formalin are differentially modulated by selective opioid receptor agonists. In addition, data suggest that peripheral and spinal δ and κ opioid receptors are important when nociceptive behaviors are established. In contrast, µ opioid receptors are more important at the beginning of the injury when the sensory system has not changed. NOP receptors participate diminishing both the development and maintenance of nociceptive behaviors. Results suggest that a barrage of afferent input induced by formalin injection initiates a long-term differential change in peripheral and spinal processing that affect the efficacy of opioid receptor agonists." @default.
- W2911696307 created "2019-02-21" @default.
- W2911696307 creator A5082481244 @default.
- W2911696307 date "1986-01-01" @default.
- W2911696307 modified "2023-10-18" @default.
- W2911696307 title "Tool holder" @default.
- W2911696307 doi "https://doi.org/10.1016/0883-2897(86)90151-0" @default.
- W2911696307 hasPublicationYear "1986" @default.
- W2911696307 type Work @default.
- W2911696307 sameAs 2911696307 @default.
- W2911696307 citedByCount "0" @default.
- W2911696307 crossrefType "journal-article" @default.
- W2911696307 hasAuthorship W2911696307A5082481244 @default.
- W2911696307 hasConcept C125439840 @default.
- W2911696307 hasConcept C126322002 @default.
- W2911696307 hasConcept C15490471 @default.
- W2911696307 hasConcept C159023312 @default.
- W2911696307 hasConcept C170493617 @default.
- W2911696307 hasConcept C185592680 @default.
- W2911696307 hasConcept C2777389121 @default.
- W2911696307 hasConcept C2777803847 @default.
- W2911696307 hasConcept C2777883359 @default.
- W2911696307 hasConcept C2777972943 @default.
- W2911696307 hasConcept C2778680407 @default.
- W2911696307 hasConcept C2779245659 @default.
- W2911696307 hasConcept C2779886867 @default.
- W2911696307 hasConcept C2780723003 @default.
- W2911696307 hasConcept C2781063702 @default.
- W2911696307 hasConcept C42219234 @default.
- W2911696307 hasConcept C71924100 @default.
- W2911696307 hasConcept C88016717 @default.
- W2911696307 hasConcept C98274493 @default.
- W2911696307 hasConceptScore W2911696307C125439840 @default.
- W2911696307 hasConceptScore W2911696307C126322002 @default.
- W2911696307 hasConceptScore W2911696307C15490471 @default.
- W2911696307 hasConceptScore W2911696307C159023312 @default.
- W2911696307 hasConceptScore W2911696307C170493617 @default.
- W2911696307 hasConceptScore W2911696307C185592680 @default.
- W2911696307 hasConceptScore W2911696307C2777389121 @default.
- W2911696307 hasConceptScore W2911696307C2777803847 @default.
- W2911696307 hasConceptScore W2911696307C2777883359 @default.
- W2911696307 hasConceptScore W2911696307C2777972943 @default.
- W2911696307 hasConceptScore W2911696307C2778680407 @default.
- W2911696307 hasConceptScore W2911696307C2779245659 @default.
- W2911696307 hasConceptScore W2911696307C2779886867 @default.
- W2911696307 hasConceptScore W2911696307C2780723003 @default.
- W2911696307 hasConceptScore W2911696307C2781063702 @default.
- W2911696307 hasConceptScore W2911696307C42219234 @default.
- W2911696307 hasConceptScore W2911696307C71924100 @default.
- W2911696307 hasConceptScore W2911696307C88016717 @default.
- W2911696307 hasConceptScore W2911696307C98274493 @default.
- W2911696307 hasIssue "5" @default.
- W2911696307 hasLocation W29116963071 @default.
- W2911696307 hasOpenAccess W2911696307 @default.
- W2911696307 hasPrimaryLocation W29116963071 @default.
- W2911696307 hasRelatedWork W1964846979 @default.
- W2911696307 hasRelatedWork W1997954118 @default.
- W2911696307 hasRelatedWork W2019248014 @default.
- W2911696307 hasRelatedWork W2041079824 @default.
- W2911696307 hasRelatedWork W2087439428 @default.
- W2911696307 hasRelatedWork W2097597104 @default.
- W2911696307 hasRelatedWork W2902638841 @default.
- W2911696307 hasRelatedWork W2905426539 @default.
- W2911696307 hasRelatedWork W3164558864 @default.
- W2911696307 hasRelatedWork W3200968396 @default.
- W2911696307 hasVolume "13" @default.
- W2911696307 isParatext "false" @default.
- W2911696307 isRetracted "false" @default.
- W2911696307 magId "2911696307" @default.
- W2911696307 workType "article" @default.