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- W2911697454 abstract "Opioids have, in addition to analgesic properties, immune altering effects including upregulation of Th2 responses. Whether this has clinical expression in altering asthma and allergic responses has not been determined. We hypothesize that in patients with chronic pain conditions, there is an increased prevalence of asthma and allergy when prescribed opioid medications. EMR review of opioid prescription for chronic pain conditions and the prevalence of allergic rhinitis and allergic conjunctivitis was conducted (n=3502). ICD coding from inpatient, emergency room and ambulatory surgery settings at Kings County Hospital in Brooklyn, NY from 2013-2017 was obtained for the following conditions: chronic pain syndrome, osteoarthritis, joint disorder, fibromyalgia, back pain, myalgia and myositis, asthma, allergic rhinitis and allergic conjunctivitis. We sought record of minimum one prescription for opioid medication. Prevalence of asthma was 8.7% (178/2049) in patients without opioid prescription versus 15.1% (220/1453) in patients with opioid prescription (OR=1.92, 95% CI [1.56, 2.40], p<0.001). Prevalence of allergic rhinitis and/or allergic conjunctivitis was 5.1% (119/2049) in patients without opioid prescription versus 10.9% (158/1453) in patients with opioid prescription (OR=1.94, 95% CI [1.51, 2.51], P<0.001). Among patients with chronic pain conditions, prescription opioid use was associated with asthma and allergy." @default.
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- W2911697454 date "2019-02-01" @default.
- W2911697454 modified "2023-10-14" @default.
- W2911697454 title "Association of Prescription Opioid Use for Chronic Pain Syndromes with Asthma and Allergy" @default.
- W2911697454 doi "https://doi.org/10.1016/j.jaci.2018.12.682" @default.
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